Protein Alignment trv and CIRBP

DIOPT Version :10

• Sequence 1: NP_001163754.3
• Gene: trv / 43362
• FlyBaseID: FBgn0085391
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_001287758.1
• Gene: CIRBP / 1153
• HGNCID: 1982
• Length: 297
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 69/303 - (22%)
• Similarity: 108/303 - (35%)
• Gaps: 83/303 - (27%)

  Fly   314 IFVGDLSSEIETQQLREAFTPFGEISDCRVVRDPQTLKSKGYGFVSFIKKSEAESAITAMNGQWL 378
            :|||.||.:...|.|.:.|:.:|:||:..||:|.:|.:|:|:|||:|....:|:.|:.||||:.:
Human     8 LFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSV 72

  Fly   379 GSRSIRTNWATRKPPASKENIKPLTFDEVYNQSSPSNCTVYVGGVNSALTALSEEVLQKTFAPYG 443
            ..|.||.:.|.:    |.:|     ....|...|......:.||....          :.|:..|
Human    73 DGRQIRVDQAGK----SSDN-----RSRGYRGGSAGGRGFFRGGRGRG----------RGFSRGG 118

  Fly   444 AIQEIRVFKDKGYAFVRFSTK-----------------------------------------EAA 467
            .        |:||...||.::                                         |.|
Human   119 G--------DRGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYGKSHSEGA 175

  Fly   468 T--HAIVGVHNTEI--------NAQPVKCSWGKESGDPNNAQTI-ATQALNSAAAAAAGFPYGVG 521
            |  ...||...|.:        ..:|..|:..:|:...:.:... .||..|.......| ..|..
Human   176 TLLWPAVGARFTLVPSPSTLGWTLRPCHCACPEEAHLSSQSHFYRRTQKPNETDQKGKG-ERGPA 239

  Fly   522 AAAAAAAYGQQLAATGC--WYSPTPTYPASSATAAAVTPAAAS 562
            ..:|....|::.|:.||  |..| ...|.....:....|..||
Human   240 GQSARCMCGRRPASLGCGGWLLP-GRRPRPGLASGVKLPLVAS 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trv	NP_001163754.3	RRM2_TIA1_like	313..387	CDD:409789	30/72 (42%)
		RRM3_TIA1_like	416..489	CDD:409790	17/123 (14%)
CIRBP	NP_001287758.1	RRM_CIRBP_RBM3	6..85	CDD:409883	31/80 (39%)