DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaTub97EF and TUBA4B

DIOPT Version :9

Sequence 1:	NP_001163753.1	Gene:	betaTub97EF / 43359	FlyBaseID:	FBgn0003890	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001342150.1	Gene:	TUBA4B / 80086	HGNCID:	18637	Length:	241	Species:	Homo sapiens

Alignment Length:	189	Identity:	79/189 - (41%)
Similarity:	117/189 - (61%)	Gaps:	7/189 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 QLFRPDNFVYGQSGAGNNWAKGHYTEGAELIDSVLEVLRKESEGCDCLQGFQLAHSLGGGTGSGL 147
            |:|.|:..:.|:..|.||:|.||||.|.|.||.:|:.:||.::.|..||||.:.||||.||||.:
Human    24 QIFHPEQLITGKEDAANNYAWGHYTIGKEFIDLLLDRIRKLADQCTGLQGFLVFHSLGRGTGSDV 88

  Fly   148 GTLLISKIREEYPDRIMNSFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETFCIDNEALYDICF 212
            .:.|:..:...|..:....||:.|:|:||..:|:|||:.|:.|..:|::|..|.:||:|:||||.
Human    89 TSFLMEWLSVNYGKKSKLGFSIYPAPQVSTAMVQPYNSILTTHTTLEHSDCAFMVDNKAIYDICH 153

  Fly   213 RTLKLSSPTYGDLNHLVSVTMSGVTTCLRFPGQLNADLRKLAVNMV-------PFPRLH 264
            ..|.:..|||.:||.|:|..:|.:|..|||.|.||.||.:...|:|       |:|.:|
Human   154 CNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVSYLTSTSPWPPMH 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTub97EF	NP_001163753.1	PLN00220	1..444	CDD:215107	79/189 (42%)
betaTub97EF	NP_001163753.1	beta_tubulin	2..426	CDD:276956	79/189 (42%)
TUBA4B	NP_001342150.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
TUBA4B	NP_001342150.1	Tubulin	20..>207	CDD:330767	76/182 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53784
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010