DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment betaTub97EF and tuba4b

DIOPT Version :9

Sequence 1:	NP_001163753.1	Gene:	betaTub97EF / 43359	FlyBaseID:	FBgn0003890	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	XP_012825888.1	Gene:	tuba4b / 549448	XenbaseID:	XB-GENE-489927	Length:	452	Species:	Xenopus tropicalis

Alignment Length:	456	Identity:	180/456 - (39%)
Similarity:	273/456 - (59%)	Gaps:	19/456 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 REIVHLQAGQCGNQIGSKFWEIISDEHGIDPNGYYHGESAL--QHERIDVYYNEASSGKYVPRAV 64
            ||.:.:..||.|.|:|:..||:...||||.|:|....:..:  ..:....:::|..:||:|||||
Frog     5 RECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFSETGAGKHVPRAV 69

  Fly    65 LIDLEPGTMDSVRQSPVGQLFRPDNFVYGQSGAGNNWAKGHYTEGAELIDSVLEVLRKESEGCDC 129
            .:||||..:|.||.....|||.|:..:.|:..|.||:|:||||.|.|:||.||:.:||.::.|..
Frog    70 FVDLEPTVIDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLDRIRKLADQCTG 134

  Fly   130 LQGFQLAHSLGGGTGSGLGTLLISKIREEYPDRIMNSFSVVPSPKVSDTVVEPYNATLSIHQLVE 194
            ||||.:.||.|||||||..:||:.::..:|..:....||:.|:|:||..||||||:.|:.|..:|
Frog   135 LQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLE 199

  Fly   195 NTDETFCIDNEALYDICFRTLKLSSPTYGDLNHLVSVTMSGVTTCLRFPGQLNADLRKLAVNMVP 259
            ::|..|.:||||:||||.|.|.:..|||.:||.|:|..:|.:|..|||.|.||.||.:...|:||
Frog   200 HSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVP 264

  Fly   260 FPRLHFFMPGFAPLTAKGSQQYRALTVAELTQQMFDAKNMMTACDPRHGRYLTVACIFRGPMSMK 324
            :||:||.:..:||:.:.....:..|:|:|:|...|:..|.|..||||||:|:....::||.:..|
Frog   265 YPRIHFPLATYAPVISAEKAYHEQLSVSEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPK 329

  Fly   325 EVDTQMYNVQSKNSSYFVEWIPNNVKVAVCDIPPRG--------LKMSATFIGNSTAIQEIFKRI 381
            :|:..:..:::|.:..||:|.|...||.:...||..        ::.:...:.|:|||.|.:.|:
Frog   330 DVNAAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTAVPGGDLAKVQRAVCMLSNTTAIAEAWARL 394

  Fly   382 SEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLISEYQQYQEATADDEVEFDDEQAEQEGY 446
            ..:|..|:.::||:|||.||||:|.||:||..:|..|..:|         :||..|..:.|.||.
Frog   395 DHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDY---------EEVGIDSYEDEDEGE 450

  Fly   447 E 447
            |
Frog   451 E 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTub97EF	NP_001163753.1	PLN00220	1..444	CDD:215107	177/451 (39%)
betaTub97EF	NP_001163753.1	beta_tubulin	2..426	CDD:276956	173/433 (40%)
tuba4b	XP_012825888.1	PTZ00335	5..442	CDD:185562	175/445 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910