DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaTub97EF and tbb-6

DIOPT Version :9

Sequence 1:	NP_001163753.1	Gene:	betaTub97EF / 43359	FlyBaseID:	FBgn0003890	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_506075.2	Gene:	tbb-6 / 179680	WormBaseID:	WBGene00006539	Length:	426	Species:	Caenorhabditis elegans

Alignment Length:	428	Identity:	243/428 - (56%)
Similarity:	324/428 - (75%)	Gaps:	7/428 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREIVHLQAGQCGNQIGSKFWEIISDEHGIDPNGYYHGESALQHERIDVYYNEASSGKYVPRAVL 65
            |:||:::|.||||||||:||||.||:|||:..:|.|.|::..|.|||..||.|....||||||:|
Worm     1 MKEIINVQVGQCGNQIGAKFWEYISEEHGLQTDGTYKGDNGSQLERITSYYKEMEGRKYVPRAIL 65

  Fly    66 IDLEPGTMDSVRQSPVGQLFRPDNFVYGQSGAGNNWAKGHYTEGAELIDSVLEVLRKESEGCDCL 130
            :||:|.:::.||.:..|:||.|:|.|.|:|||||||::|:|.:|||::|.||.|:|:|:|..|.|
Worm    66 VDLDPESINYVRSTQYGKLFDPENAVSGESGAGNNWSRGYYEQGAEIVDKVLSVIRREAEAADSL 130

  Fly   131 QGFQLAHSLGGGTGSGLGTLLISKIREEYPDRIMNSFSVVPSPKVSDTVVEPYNATLSIHQLVEN 195
            :||||.||||||||||||:|||||:||||.|:.:::.|::||.||||||||||||.||:..|::|
Worm   131 EGFQLIHSLGGGTGSGLGSLLISKLREEYSDKTLSTCSIIPSAKVSDTVVEPYNAILSMPHLMDN 195

  Fly   196 TDETFCIDNEALYDICFRTLKLSS-PTYGDLNHLVSVTMSGVTTCLRFPGQLNADLRKLAVNMVP 259
            .||.|||||||::|||...|||.: .||||||||.|:.:||:||..||.|.|..|:|||  |...
Worm   196 CDENFCIDNEAIFDICQYNLKLENRVTYGDLNHLASLALSGITTFQRFKGNLKTDIRKL--NTAG 258

  Fly   260 FPRLHFFMPGFAPLTAKGSQQYRALTVAELTQQMFDAKNMMTACDPRHGRYLTVACIFRGPMSMK 324
            .|||||||..|||:..||....:|.::::||||:.||||:|| |:...|::|:.|.|:||..:.|
Worm   259 SPRLHFFMTSFAPVYGKGIIDCQAFSISDLTQQVLDAKNIMT-CNHNQGKFLSSAIIYRGQQTEK 322

  Fly   325 EVDTQMYNVQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSATFIGNSTAIQEIFKRISEQFTAMF 389
            :...|:.:|::::.|..:|.:|.:....|||||.||||.|||||.|||||||..||||:||..:|
Worm   323 KDAEQIISVENEDPSEMIESLPKSTNTDVCDIPSRGLKTSATFIANSTAIQEPLKRISKQFAGLF 387

  Fly   390 RRKAFLHWYTGEGMDEMEFTEAESNMNDLISEYQQYQE 427
            ||||||||||   |:|.|||:||:.:||||||:|||::
Worm   388 RRKAFLHWYT---MEESEFTDAENKVNDLISEFQQYEK 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTub97EF	NP_001163753.1	PLN00220	1..444	CDD:215107	243/428 (57%)
betaTub97EF	NP_001163753.1	beta_tubulin	2..426	CDD:276956	241/424 (57%)
tbb-6	NP_506075.2	PTZ00010	1..421	CDD:240228	242/425 (57%)
tbb-6	NP_506075.2	beta_tubulin	2..421	CDD:276956	241/424 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D259639at33208
OrthoFinder	1	1.000	-	-		FOG0000096
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11588
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020