DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4849 and EFTUD2

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001245282.1	Gene:	EFTUD2 / 9343	HGNCID:	30858	Length:	972	Species:	Homo sapiens

Alignment Length:	975	Identity:	733/975 - (75%)
Similarity:	834/975 - (85%)	Gaps:	3/975 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSDLYDEFGNYIGPDLDSDEEDEQSIYGQPDVQDDPEDAMDEDEVEPQEDEDKEVTAVVLHEDK 65
            ||:||||||||||||:|||||:|::......|: |:.:|..|:|:| ...|:|.....|||||||
Human     1 MDTDLYDEFGNYIGPELDSDEDDDELGRETKDL-DEMDDDDDDDDV-GDHDDDHPGMEVVLHEDK 63

  Fly    66 RYYPSAVEVYGPDVETIVQEEDAQPLDKPLIEPVKKLKFQIKEQDMQETTYDMEFMADLMDTPPL 130
            :|||:|.|||||:|||||||||.|||.:|:|:|||..||.:.||.:..|.|:|:|:|||||...|
Human    64 KYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSEL 128

  Fly   131 IRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQERGCSIKATPVTLVLQDV 195
            ||||.|.||||||||.||||||.||||:.....::.|.|||.||||||||..||:||||:||.|.
Human   129 IRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTPVTVVLPDT 193

  Fly   196 KQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQAITVCIN 260
            |.||||.||.|||||||||||.||.:|:|||||||||||||||||||||:|||||||.|:|||||
Human   194 KGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCIN 258

  Fly   261 KIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYGAPDDNLLVSPILGNVCFASSLYGFCFTLKS 325
            |||||||||||||.|||:||:|||:|||||:|.| :.|:||::||:||||||:||.|..||||.|
Human   259 KIDRLILELKLPPTDAYYKLRHIVDEVNGLISMY-STDENLILSPLLGNVCFSSSQYSICFTLGS 322

  Fly   326 FAKLYADTYEGVAYLDFAKRLWGDMYFNSKTRKFSKKQPHNSAQRSFVEFILEPMYKLIAQVVGD 390
            |||:||||:..:.|.:||||||||:|||.|||||:||.|.:|:|||||||||||:||::||||||
Human   323 FAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKAPTSSSQRSFVEFILEPLYKILAQVVGD 387

  Fly   391 VDTTLSDTLAELNVRVSKEEMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHI 455
            |||:|..||.||.:.::|||:|.||||||||||.:|.|:.:|||||||:||.||...||.|::|.
Human   388 VDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHT 452

  Fly   456 YTGPKEGDIYRDMISCNQYGTLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQ 520
            |||..:.|:...|..|:..|.||.|::|||..||...|....|::|||:||||.|:||||||||:
Human   453 YTGGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLE 517

  Fly   521 DEEDSRILQVGRLWVFESRYKVELNRVPAGNWVLIEGIDQCIVKTSTIVDINVPEDLYIFRPLKF 585
            |||||:|..|||||:..:||.:|:|||||||||||||:||.||||:||.:....|:..|||||||
Human   518 DEEDSQICTVGRLWISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKF 582

  Fly   586 NTQSIIKIAVEPVNPSELPKMLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKM 650
            ||.|:||||||||||||||||||||||||||||.|:|:|||||||||||||||||||||||||||
Human   583 NTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKM 647

  Fly   651 YSEIDIKVADPVVAFCETVVETSSLKCFAETPNKKNKITMISEPLEKGLAEDIENGTVCINWNKK 715
            |||||||||||||.|||||||||||||||||||||||||||:|||||||||||||..|.|.||:|
Human   648 YSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRK 712

  Fly   716 RIGEFFQVNYDWDLLAARSIWAFGPDSTGPNILVDDTLPSEVDKNLLTAVKDSIVQGFQWGTREG 780
            ::|||||..|||||||||||||||||:|||||||||||||||||.||.:||||||||||||||||
Human   713 KLGEFFQTKYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREG 777

  Fly   781 PLCEEPIRNVKFKILDGVIANEALHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADC 845
            |||:|.||||||||||.|:|.|.|||||||||||||||.|||||||||||||||.||||||||||
Human   778 PLCDELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPADC 842

  Fly   846 VSAVYTVLARRRGHVTQDAPVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIV 910
            ||||||||||||||||||||:.|||:||||||||||||||||||||||||||||.||||||||||
Human   843 VSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSVFHHWQIV 907

  Fly   911 PGDPLDKSIIIRPLEPQQASHLAREFMIKTRRRKGLSEDVSINKFFDDPMLLELARQDVLINYPL 975
            |||||||||:|||||||.|.||||||||||||||||||||||:||||||||||||:|||::|||:
Human   908 PGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLELAKQDVVLNYPM 972

Fly 976 975
Human 973 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623	63/106 (59%)
		PTZ00416	115..957	CDD:240409	651/841 (77%)
		Snu114p	132..340	CDD:206730	152/207 (73%)
		Translation_Factor_II_like	477..568	CDD:295476	59/90 (66%)
		snRNP_III	589..660	CDD:293921	66/70 (94%)
		EF2_IV_snRNP	660..837	CDD:238840	153/176 (87%)
		eEF2_C_snRNP	832..911	CDD:239765	73/78 (94%)
EFTUD2	NP_001245282.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		28/54 (52%)
		EFTUD2	4..110	CDD:406414	63/107 (59%)
		FusA	122..954	CDD:357662	646/832 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149833
Domainoid	1	1.000	366	1.000	Domainoid score	I929
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3133
Inparanoid	1	1.050	1494	1.000	Inparanoid score	I102
Isobase	1	0.950	-	0	Normalized mean entropy	S520
OMA	1	1.010	-	-		QHG54470
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	1	1.000	-	-		FOG0004923
OrthoInspector	1	1.000	-	-		oto90872
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	1	1.100	-	-	LDO	PTHR42908
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3947
SonicParanoid	1	1.000	-	-		X2958
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750