DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4849 and GFM1

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001295093.1	Gene:	GFM1 / 85476	HGNCID:	13780	Length:	770	Species:	Homo sapiens

Alignment Length:	855	Identity:	185/855 - (21%)
Similarity:	301/855 - (35%)	Gaps:	259/855 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 IRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYT-------------------DTLFTE 176
            |||:.:..|:..|||               |:.||.|.||                   |::..|
Human    46 IRNIGISAHIDSGKT---------------TLTERVLYYTGRIAKMHEVKGKDGVGAVMDSMELE 95

  Fly   177 QERGCSIKATPVTLVLQDVKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNT 241
            ::||.:|::.....:.:||.     :||.||||||:|:.|...|:|:.||.||.:.|..||...|
Human    96 RQRGITIQSAATYTMWKDVN-----INIIDTPGHVDFTIEVERALRVLDGAVLVLCAVGGVQCQT 155

  Fly   242 ERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYGAPDDNLLVSPI 306
            ..:.:...:........|||:||:........|....||.|
Human   156 MTVNRQMKRYNVPFLTFINKLDRMGSNPARALQQMRSKLNH------------------------ 196

  Fly   307 LGNVCFASSLYGFCFTLKSFAKL------YADTYEGVAYLDFAKRLWGDMYFNSKTRKFSKKQPH 365
              |..|.....|.....|....|      |.|...|....||...||     |...|..|:...:
Human   197 --NAAFMQIPMGLEGNFKGIVDLIEERAIYFDGDFGHFLRDFLPLLW-----NWDRRSGSQIVRY 254

  Fly   366 NSAQRSFVEFILEPMYKLIAQVVGDVDTTLSD--------TLAELNVRVSKEEMKSNIRPLLRLV 422
            ............:...:|| :.|.:.|..|.:        ::::|.:.:.:..:|.:..|:
Human   255 GEIPAELRAAATDHRQELI-ECVANSDEQLGEMFLEEKIPSISDLKLAIRRATLKRSFTPV---- 314

  Fly   423 CNRFMGDC------SGFVDMCVEHIKSPLE---------------------NAKRKVDHIYTGPK 460
               |:|..      ...:|..:|::.:|.|                     |:.|...|.:.|
Human   315 ---FLGSALKNKGVQPLLDAVLEYLPNPSEVQNYAILNKEDDSKEKTKILMNSSRDNSHPFVG-- 374

  Fly   461 EGDIYRDMISCNQYGTLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDS 525
                ....:...::|.|                 ...|...|.|..|..:      |..:..:..
Human   375 ----LAFKLEVGRFGQL-----------------TYVRSYQGELKKGDTI------YNTRTRKKV 412

  Fly   526 RILQVGRLWVFESRYKVELNRVPAGNWVLIEGIDQCIVKTST--------IVDINVPEDLYIFRP 582
            |:.::.|:   .:....::..|.||:...:.|||.....|.|        :..|:||:
Human   413 RLQRLARM---HADMMEDVEEVYAGDICALFGIDCASGDTFTDKANSGLSMESIHVPD------- 467

  Fly   583 LKFNTQSIIKIAVEPVNPSELPKMLDGLRKVNKSYPLLSTRVE-ESGEHVILGTGELYLDCVMHD 646
                  .:|.||::|.|.::|.|...|:.:..:..|......: |:.|.||.|.|||:|:.....
Human   468 ------PVISIAMKPSNKNDLEKFSKGIGRFTREDPTFKVYFDTENKETVISGMGELHLEIYAQR 526

  Fly   647 LRKMYSEIDIKVADPVVAFCETVVETSSLKCFAETP----NKK--------NKITMISEPLEKGL 699
            |.:.|. .......|.|||.||:.        |..|    :||        .|:..:.|||:
Human   527 LEREYG-CPCITGKPKVAFRETIT--------APVPFDFTHKKQSGGAGQYGKVIGVLEPLD--- 579

  Fly   700 AEDIENGTVCINWNKKRIGEFFQVNYDWDLLAARSIWAFGPDSTGPNILVDDTLPSEVDKNLLTA 764
            .||                 :.::.:.                       |:|..|.:.|..:.|
Human   580 PED-----------------YTKLEFS-----------------------DETFGSNIPKQFVPA 604

  Fly   765 VKDSIVQGFQWGTREGPLCEEPIRNVKFKILDG----VIANEA--LHRGGGQIIPTARRVAYSAF 823
            |:    :||.....:|||....:..::|.:.||    |.:||.  :..|.|.:        ..|.
Human   605 VE----KGFLDACEKGPLSGHKLSGLRFVLQDGAHHMVDSNEISFIRAGEGAL--------KQAL 657

  Fly   824 LMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVT-QDAPVSGSPIYTIKAFIPAIDSFGFE 887
            ..||..::||.:.|||.||.:....|...:.||.|.:| ||..   ...:|:.|.:|..|.||:.
Human   658 ANATLCILEPIMAVEVVAPNEFQGQVIAGINRRHGVITGQDGV---EDYFTLYADVPLNDMFGYS 719

  Fly   888 TDLRTHTQGQ 897
            |:||:.|:|:
Human   720 TELRSCTEGK 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	185/855 (22%)
		Snu114p	132..340	CDD:206730	56/232 (24%)
		Translation_Factor_II_like	477..568	CDD:295476	16/98 (16%)
		snRNP_III	589..660	CDD:293921	20/71 (28%)
		EF2_IV_snRNP	660..837	CDD:238840	40/194 (21%)
		eEF2_C_snRNP	832..911	CDD:239765	25/67 (37%)
GFM1	NP_001295093.1	EF-G	48..339	CDD:206673	74/349 (21%)
		PRK12740	52..751	CDD:237186	182/849 (21%)
		mtEFG1_II_like	372..452	CDD:293908	17/111 (15%)
		EFG_III	466..541	CDD:293919	21/88 (24%)
		EFG_mtEFG1_IV	544..660	CDD:238715	33/178 (19%)
		mtEFG1_C	666..743	CDD:239764	25/67 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810