DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4849 and EFT1

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_014776.1	Gene:	EFT1 / 854301	SGDID:	S000005659	Length:	842	Species:	Saccharomyces cerevisiae

Alignment Length:	853	Identity:	308/853 - (36%)
Similarity:	497/853 - (58%)	Gaps:	42/853 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 YDMEFMADLMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQERG 180
            :.::.|..|||....:||::::.|:.|||:|..|.|: |........:..:.|:|||...|||||
Yeast     4 FTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLV-QRAGIISAAKAGEARFTDTRKDEQERG 67

  Fly   181 CSIKATPVTLV-------LQDVKQK----SYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAA 234
            .:||:|.::|.       ::::|||    |:|:|:.|:||||:||.|.|||:|::||.::.:|..
Yeast    68 ITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTI 132

  Fly   235 EGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYGAPDD 299
            |||.:.||.:|:.|:.||....|.|||:||.:|||::..:|.|......||.||.::|||.   |
Yeast   133 EGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYA---D 194

  Fly   300 NLL----VSPILGNVCFASSLYGFCFTLKSFAKLYADTYEGVAYLDFAKRLWGDMYFNSKTRKFS 360
            .:|    |.|..|.|.|.|.|:|:.||::.||..||..: ||.......|||||.:||.||:|::
Yeast   195 EVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKF-GVDKAKMMDRLWGDSFFNPKTKKWT 258

  Fly   361 KKQPH---NSAQRSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRVSKEEMKSNIRPLLRLV 422
            .|...   ...:|:|..|||:|:::|...::......:...|.:|.:.:..:|.....:.||::|
Yeast   259 NKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDEKDLEGKALLKVV 323

  Fly   423 CNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMISCNQYGTLMVHSSKMYPN 487
            ..:|:......::|.|.|:.||:.....:.:.:|.||.:......:.:|:....||::.|||.|.
Yeast   324 MRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKNCDPKADLMLYVSKMVPT 388

  Fly   488 DDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWVFESRYKVELNRVPAGNW 552
            .|...|....|:.:||:.:||:||:.|.||....::|..|..:.|:.:...|:...::..||||.
Yeast   389 SDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNI 453

  Fly   553 VLIEGIDQCIVKTSTIVDINVPEDLYIFRPLKFNTQSIIKIAVEPVNPSELPKMLDGLRKVNKSY 617
            :.:.||||.::||.|   :...|..:..:.:||:...::::|||..|.::|||:::||::::||.
Yeast   454 IGLVGIDQFLLKTGT---LTTSETAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSD 515

  Fly   618 PLLSTRVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFCETVVETSSLKCFAETP 682
            |.:.|.:.|||||::.|||||:|:..:.||...::.:.:|::.||||:.|||...||....:::|
Yeast   516 PCVLTYMSESGEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSP 580

  Fly   683 NKKNKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLLAARSIWAFGPDSTGPNI 747
            ||.|:|.:.:||:::.::..||||.:....:.|........:|.||:..||.||.||||..|||:
Yeast   581 NKHNRIYLKAEPIDEEVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNL 645

  Fly   748 LVDDTLPSEVDKNLLTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILDGVIANEALHRGGGQII 812
            ::|.|...:    .|..:|||:|..|||.|:|||:..|.:|:|:..|||..:..:|:||||||||
Yeast   646 VIDQTKAVQ----YLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQII 706

  Fly   813 PTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQDAPVSGSPIYTIKAF 877
            ||.||..|:.||:|.|::.||...||:|.|...|..:|:||.::||.|..:....|:|::|:||:
Yeast   707 PTMRRATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAY 771

  Fly   878 IPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIIRPLEPQQASHLAREFMIKTRR 942
            :|..:||||..:||..|.||||...||.||..:..||||            .:..|.|.::..|:
Yeast   772 LPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLD------------PTSKAGEIVLAARK 824

  Fly   943 RKGLSEDV 950
            |.|:.|:|
Yeast   825 RHGMKEEV 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	308/853 (36%)
		Snu114p	132..340	CDD:206730	89/222 (40%)
		Translation_Factor_II_like	477..568	CDD:295476	32/90 (36%)
		snRNP_III	589..660	CDD:293921	27/70 (39%)
		EF2_IV_snRNP	660..837	CDD:238840	75/176 (43%)
		eEF2_C_snRNP	832..911	CDD:239765	34/78 (44%)
EFT1	NP_014776.1	PTZ00416	1..842	CDD:240409	308/853 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710