DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4849 and MEF1

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_013170.1	Gene:	MEF1 / 850758	SGDID:	S000004059	Length:	761	Species:	Saccharomyces cerevisiae

Alignment Length:	908	Identity:	210/908 - (23%)
Similarity:	341/908 - (37%)	Gaps:	255/908 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 EQDMQETTYDMEFMADLMD------TPP------LIRNVALVGHLHHGKTTFVDCLIRQTHPQFE 160
            |..:..:||:.|.:  |:|      ||.      .:||:.:..|:..|||||.
Yeast    37 ESPLARSTYEEEKV--LVDEIKQKLTPDDIGRCNKLRNIGISAHIDSGKTTFT------------ 87

  Fly   161 TMEERQLRYT-------------------DTLFTEQERGCSIKATPVTLVLQDVKQKSYLLNIFD 206
               ||.|.||                   |::..|:|:|.:|::. .|....|.:.|:|..|:.|
Yeast    88 ---ERVLYYTKRIKAIHEVRGRDNVGAKMDSMDLEREKGITIQSA-ATYCSWDKEGKNYHFNLID 148

  Fly   207 TPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQAITVCINKIDRLILELKL 271
            ||||::|:.|...|:|:.||.||.:.|..||...|..:.:...:........|||:||:
Yeast   149 TPGHIDFTIEVERALRVLDGAVLVVCAVSGVQSQTVTVDRQMRRYNVPRVTFINKMDRM------ 207

  Fly   272 PPQDAYFKLKHIVEEVNGLLSTYGAPDDNLLVSPILGNVCFASSLYGFCFTLKSFAKLYADTYEG 336
             ..|.:    ..:|::|..|....|     .|...:|:   .|||.|
Yeast   208 -GSDPF----RAIEQLNSKLKIPAA-----AVQIPIGS---ESSLSG------------------ 241

  Fly   337 VAYLDFAKRLWGDMYFNSKTRKFSKK--QPHNSAQRSFVEFILEPMYKLIAQVVGDVDTTLSDTL 399
              .:|...|:  .:|......:..:|  .|.|      ::.::|...:|:.:.:.|||    |.:
Yeast   242 --VVDLINRV--AIYNKGDNGEIIEKGPVPEN------LKPLMEEKRQLLIETLADVD----DEM 292

  Fly   400 AELNVRVSKEEMKSNIRPLLR--LVCNRF----MGDC---SGF---VDMCVEHIKSPLE------ 446
            ||:.:. .||.....|:..:|  .:...|    ||..   :|.   :|..|:::.:|.|
Yeast   293 AEMFLE-EKEPTTQQIKDAIRRSTIARSFTPVLMGSALANTGIQPVLDAIVDYLPNPSEVLNTAL 356

  Fly   447 ---NAKRKVDHI--YTGPKEGDIYRDMISCNQYGTLMVHSSKMYPNDDCTFFQVLARIVSGTLHA 506
               |.:.||:.:  ...|..|..::  :...:||.|                 ...|:..|.|..
Yeast   357 DVSNNEAKVNLVPAVQQPFVGLAFK--LEEGKYGQL-----------------TYVRVYQGRLRK 402

  Fly   507 GQEVRVLGENYTLQDEEDSRILQVGRLWVFESRYKVELNRVPAGNWVLIEGIDQCIVKTSTIVDI 571
            |        || :.:.:..:.::|.||....|....:::.|.:|......||| | ....|..|.
Yeast   403 G--------NY-ITNVKTGKKVKVARLVRMHSSEMEDVDEVGSGEICATFGID-C-ASGDTFTDG 456

  Fly   572 NVP---EDLYIFRPLKFNTQSIIKIAVEPVNPSELPKMLDGLRKVNKSYPLLSTRVE-ESGEHVI 632
            :|.   ..:|:       ..:::.:::.| |..:.......|.:..|..|....:.: ||.|.:|
Yeast   457 SVQYSMSSMYV-------PDAVVSLSITP-NSKDASNFSKALNRFQKEDPTFRVKFDPESKETII 513

  Fly   633 LGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFCETVVETSSLKCFAETPNKKNKITMISEPLEK 697
            .|.|||:|:..:..:|:.|: :|.....|.|::.|::.
Yeast   514 SGMGELHLEIYVERMRREYN-VDCVTGKPQVSYRESIT--------------------------- 550

  Fly   698 GLAEDIENGTVCINWNKKRIGEFFQVNYDWDLLAARSIWAFGP--DSTGPNI----LVDDTLPSE 756
             :..|.:      ..:||:.|...|.        .|.|....|  |.|..||    :|...:|
Yeast   551 -IPADFD------YTHKKQSGGAGQY--------GRVIGTLSPVDDITKGNIFETAIVGGRIP-- 598

  Fly   757 VDKNLLTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILDGVI----ANEALHRGGGQIIPTARR 817
             ||.|....|     ||:....:|||....:.:||..|.||.|    :||...:       ||..
Yeast   599 -DKYLAACGK-----GFEEVCEKGPLIGHRVLDVKMLINDGAIHAVDSNELSFK-------TATM 650

  Fly   818 VAY-SAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQDAPVSGSPIYTIKAFIPAI 881
            .|: .|||.|.|.:|||.:.|.|.:|.:....|..:|.:.:. |.||.. :|...:|:||.....
Yeast   651 SAFRDAFLRAQPVIMEPIMNVSVTSPNEFQGNVIGLLNKLQA-VIQDTE-NGHDEFTLKAECALS 713

  Fly   882 DSFGFETDLRTHTQGQA-FCLSVFHHWQIVPGDPLDKSIIIRPLEPQQASHLAREFMIKTRRR 943
            ..|||.|.||..|||:. |.|...|:               .|..|.....|..||..|..::
Yeast   714 TMFGFATSLRASTQGKGEFSLEFSHY---------------APTAPHVQKELISEFQKKQAKK 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623	1/2 (50%)
		PTZ00416	115..957	CDD:240409	209/901 (23%)
		Snu114p	132..340	CDD:206730	56/226 (25%)
		Translation_Factor_II_like	477..568	CDD:295476	17/90 (19%)
		snRNP_III	589..660	CDD:293921	17/71 (24%)
		EF2_IV_snRNP	660..837	CDD:238840	45/187 (24%)
		eEF2_C_snRNP	832..911	CDD:239765	26/79 (33%)
MEF1	NP_013170.1	FusA	68..760	CDD:223556	202/872 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810