DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4849 and LOS1

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001321033.1	Gene:	LOS1 / 842058	AraportID:	AT1G56070	Length:	843	Species:	Arabidopsis thaliana

Alignment Length:	869	Identity:	322/869 - (37%)
Similarity:	522/869 - (60%)	Gaps:	53/869 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 MEFMAD----LMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQE 178
            ::|.||    :||....|||::::.|:.|||:|..|.|:.......:.: ...:|.|||...|.|
plant     2 VKFTADELRRIMDYKHNIRNMSVIAHVDHGKSTLTDSLVAAAGIIAQEV-AGDVRMTDTRADEAE 65

  Fly   179 RGCSIKATPVTLV--LQDVKQKS---------YLLNIFDTPGHVNFSDEATAAMRMSDGVVLFID 232
            ||.:||:|.::|.  :.|...||         ||:|:.|:||||:||.|.|||:|::||.::.:|
plant    66 RGITIKSTGISLYYEMTDESLKSFTGARDGNEYLINLIDSPGHVDFSSEVTAALRITDGALVVVD 130

  Fly   233 AAEGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYGAP 297
            ..|||.:.||.:|:.|:.||....:.:||:||..|||::..::||.....::|..|.:::||
plant   131 CIEGVCVQTETVLRQALGERIRPVLTVNKMDRCFLELQVDGEEAYQTFSRVIENANVIMATY--- 192

  Fly   298 DDNLL----VSPILGNVCFASSLYGFCFTLKSFAKLYADTYEGVAYLDFAKRLWGDMYFNSKTRK 358
            :|.||    |.|..|.|.|::.|:|:.|||.:|||:||..: ||......:||||:.:|:..|||
plant   193 EDPLLGDVQVYPEKGTVAFSAGLHGWAFTLTNFAKMYASKF-GVVESKMMERLWGENFFDPATRK 256

  Fly   359 FSKKQPHN-SAQRSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRVSKEEMKSNIRPLLRLV 422
            :|.|...: :.:|.||:|..||:.::||..:.|....|...||:|.|.:..:|.:...:||::.|
plant   257 WSGKNTGSPTCKRGFVQFCYEPIKQIIATCMNDQKDKLWPMLAKLGVSMKNDEKELMGKPLMKRV 321

  Fly   423 CNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMI-SCNQYGTLMVHSSKMYP 486
            ...::...:..::|.:.|:.||....:.:|:::|.||.: |.|.:.| :|:..|.||::.|||.|
plant   322 MQTWLPASTALLEMMIFHLPSPHTAQRYRVENLYEGPLD-DQYANAIRNCDPNGPLMLYVSKMIP 385

  Fly   487 NDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWVFESRYKVELNRVPAGN 551
            ..|...|....|:.:|.:..|.:||::|.||...:::|.....|.|..::..:.:..:..||.||
plant   386 ASDKGRFFAFGRVFAGKVSTGMKVRIMGPNYIPGEKKDLYTKSVQRTVIWMGKRQETVEDVPCGN 450

  Fly   552 WVLIEGIDQCIVKTSTIVDINVPE-DLYIFRPLKFNTQSIIKIAVEPVNPSELPKMLDGLRKVNK 615
            .|.:.|:||.|.|.:|:.  |..| |.:..|.:||:...::::||:....|:|||:::||:::.|
plant   451 TVAMVGLDQFITKNATLT--NEKEVDAHPIRAMKFSVSPVVRVAVQCKVASDLPKLVEGLKRLAK 513

  Fly   616 SYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKMY-SEIDIKVADPVVAFCETVVETSSLKCFA 679
            |.|::...:||||||::.|.|||:|:..:.||:..: ...:|..:||||:|.|||.:.|:....:
plant   514 SDPMVVCTMEESGEHIVAGAGELHLEICLKDLQDDFMGGAEIIKSDPVVSFRETVCDRSTRTVMS 578

  Fly   680 ETPNKKNKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLLAARSIWAFGPDSTG 744
            ::|||.|::.|.:.|:|:||||.|::|.:....:.|...:.....:.||...|:.||||||::||
plant   579 KSPNKHNRLYMEARPMEEGLAEAIDDGRIGPRDDPKIRSKILAEEFGWDKDLAKKIWAFGPETTG 643

  Fly   745 PNILVDDTLPSEVDKNL--LTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILDGVIANEALHRG 807
            ||::||      :.|.:  |..:|||:|.||||.::||||.||.:|.:.|::.|.|:.::|:|||
plant   644 PNMVVD------MCKGVQYLNEIKDSVVAGFQWASKEGPLAEENMRGICFEVCDVVLHSDAIHRG 702

  Fly   808 GGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQDAPVSGSPIY 872
            |||:|||||||.|::.:.|.|||:||...||:|||...:..:|:||.::||||.::....|:|:|
plant   703 GGQVIPTARRVIYASQITAKPRLLEPVYMVEIQAPEGALGGIYSVLNQKRGHVFEEMQRPGTPLY 767

  Fly   873 TIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIIRPLEP-QQASHLAREF 936
            .|||::|.::||||.:.||..|.||||...||.||:::..|         |||| .|||.|..:.
plant   768 NIKAYLPVVESFGFSSQLRAATSGQAFPQCVFDHWEMMSSD---------PLEPGTQASVLVADI 823

  Fly   937 MIKTRRRKGLSEDVSINKFFDDPM 960
                |:||||.|.::....|:|.:
plant   824 ----RKRKGLKEAMTPLSEFEDKL 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	320/864 (37%)
		Snu114p	132..340	CDD:206730	84/222 (38%)
		Translation_Factor_II_like	477..568	CDD:295476	29/90 (32%)
		snRNP_III	589..660	CDD:293921	25/71 (35%)
		EF2_IV_snRNP	660..837	CDD:238840	79/178 (44%)
		eEF2_C_snRNP	832..911	CDD:239765	36/78 (46%)
LOS1	NP_001321033.1	PLN00116	1..843	CDD:177730	322/867 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720