DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4849 and MEE5

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001321282.1	Gene:	MEE5 / 837131	AraportID:	AT1G06220	Length:	987	Species:	Arabidopsis thaliana

Alignment Length:	983	Identity:	592/983 - (60%)
Similarity:	755/983 - (76%)	Gaps:	21/983 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSDLYDEFGNYIGPDLDSDEEDEQSIYGQPDVQDD--PEDAMDEDE--------VEPQEDEDKE 55
            |:|.||||||||:||:::||.:.:..:..: |:||.  .|:..|.::        :....|.:.|
plant     1 MESSLYDEFGNYVGPEIESDRDSDDEVEDE-DLQDKHLEENGSDGEQGPGGSNGWITTINDVEME 64

  Fly    56 VTAVVLHEDKRYYPSAVEVYGPDVETIVQEEDAQPLDKPLIEPVKKLKFQIKEQDMQETTYDMEF 120
             ..:||.|||:|||:|.||||.||||:|.:||.|||::|:|:||:.::|::..:| |.|....:|
plant    65 -NQIVLPEDKKYYPTAEEVYGEDVETLVMDEDEQPLEQPIIKPVRDIRFEVGVKD-QATYVSTQF 127

  Fly   121 MADLMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTH--PQFETMEERQLRYTDTLFTEQERGCSI 183
            :..||..|.|:|||||||||.||||.|:|.|:.|||  ..|....|:.::||||...||||..||
plant   128 LIGLMSNPALVRNVALVGHLQHGKTVFMDMLVEQTHHMSTFNAKNEKHMKYTDTRVDEQERNISI 192

  Fly   184 KATPVTLVLQDVKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHA 248
            ||.|::|||:|.:.||||.||.|||||||||||.||::|::||.||.:|||||||:||||.::||
plant   193 KAVPMSLVLEDSRSKSYLCNIMDTPGHVNFSDEMTASLRLADGAVLIVDAAEGVMVNTERAIRHA 257

  Fly   249 VQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYGAPDDNL-LVSPILGNVCF 312
            :|:...|.|.|||:||||.||||||:|||:||:|.:|.:|..:|.......:| |:.|..|||||
plant   258 IQDHLPIVVVINKVDRLITELKLPPRDAYYKLRHTIEVINNHISAASTTAGDLPLIDPAAGNVCF 322

  Fly   313 ASSLYGFCFTLKSFAKLYADTYEGVAYLD---FAKRLWGDMYFNSKTRKFSKKQPHNSAQRSFVE 374
            ||...|:.|||:||||:||..: ||| :|   ||.|||||:|::|.||.|.:..|....:|:||:
plant   323 ASGTAGWSFTLQSFAKMYAKLH-GVA-MDVDKFASRLWGDVYYHSDTRVFKRSPPVGGGERAFVQ 385

  Fly   375 FILEPMYKLIAQVVGDVDTTLSDTLAELNVRVSKEEMKSNIRPLLRLVCNRFMGDCSGFVDMCVE 439
            |||||:||:.:||:|:...::..|||||.|.:|....|.|:||||||.|:...|..|||.||.|:
plant   386 FILEPLYKIYSQVIGEHKKSVETTLAELGVTLSNSAYKLNVRPLLRLACSSVFGSASGFTDMLVK 450

  Fly   440 HIKSPLENAKRKVDHIYTGPKEGDIYRDMISCNQYGTLMVHSSKMYPNDDCTFFQVLARIVSGTL 504
            ||.||.|.|.|||||.|||.|:..||..|:.|:..|.|||:.:|:||..|.:.|.|..|:.||.|
plant   451 HIPSPREAAARKVDHSYTGTKDSPIYESMVECDPSGPLMVNVTKLYPKSDTSVFDVFGRVYSGRL 515

  Fly   505 HAGQEVRVLGENYTLQDEEDSRILQVGRLWVFESRYKVELNRVPAGNWVLIEGIDQCIVKTSTIV 569
            ..||.||||||.|:.:||||..|.:|.:||::::||::.::..|.|:||||||:|..|:||:|:.
plant   516 QTGQSVRVLGEGYSPEDEEDMTIKEVTKLWIYQARYRIPVSSAPPGSWVLIEGVDASIMKTATLC 580

  Fly   570 DINVPEDLYIFRPLKFNTQSIIKIAVEPVNPSELPKMLDGLRKVNKSYPLLSTRVEESGEHVILG 634
            :.:..||:||||.|:|||..::|.|.||:||||||||::||||::|||||..|:|||||||.|||
plant   581 NASYDEDVYIFRALQFNTLPVVKTATEPLNPSELPKMVEGLRKISKSYPLAITKVEESGEHTILG 645

  Fly   635 TGELYLDCVMHDLRKMYSEIDIKVADPVVAFCETVVETSSLKCFAETPNKKNKITMISEPLEKGL 699
            |||||||.:|.|||::|||:::|||||||:|||||||:||:||||||||||||||||:|||::||
plant   646 TGELYLDSIMKDLRELYSEVEVKVADPVVSFCETVVESSSMKCFAETPNKKNKITMIAEPLDRGL 710

  Fly   700 AEDIENGTVCINWNKKRIGEFFQVNYDWDLLAARSIWAFGPDSTGPNILVDDTLPSEVDKNLLTA 764
            |||||||.|.|:||:|::|:||:..|||||||||||||||||..|||||:|||||:|||:||:.|
plant   711 AEDIENGVVSIDWNRKQLGDFFRTKYDWDLLAARSIWAFGPDKQGPNILLDDTLPTEVDRNLMMA 775

  Fly   765 VKDSIVQGFQWGTREGPLCEEPIRNVKFKILDGVIANEALHRGGGQIIPTARRVAYSAFLMATPR 829
            ||||||||||||.||||||:||||||||||:|..||.|.||||.||:||||||||||||||||||
plant   776 VKDSIVQGFQWGAREGPLCDEPIRNVKFKIVDARIAPEPLHRGSGQMIPTARRVAYSAFLMATPR 840

  Fly   830 LMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQDAPVSGSPIYTIKAFIPAIDSFGFETDLRTHT 894
            ||||..:||:|.|.|||:|:||||:|||||||.|.|..|:|.|.:|||:|.|:|||||||||.||
plant   841 LMEPVYYVEIQTPIDCVTAIYTVLSRRRGHVTSDVPQPGTPAYIVKAFLPVIESFGFETDLRYHT 905

  Fly   895 QGQAFCLSVFHHWQIVPGDPLDKSIIIRPLEPQQASHLAREFMIKTRRRKGLSEDVSINKFFDDP 959
            ||||||||||.||.|||||||||:|.:|||||....|||||||:|||||||:|||||.|||||:.
plant   906 QGQAFCLSVFDHWAIVPGDPLDKAIQLRPLEPAPIQHLAREFMVKTRRRKGMSEDVSGNKFFDEA 970

  Fly   960 MLLELARQ 967
            |::|||:|
plant   971 MMVELAQQ 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623	47/116 (41%)
		PTZ00416	115..957	CDD:240409	533/847 (63%)
		Snu114p	132..340	CDD:206730	123/210 (59%)
		Translation_Factor_II_like	477..568	CDD:295476	44/90 (49%)
		snRNP_III	589..660	CDD:293921	48/70 (69%)
		EF2_IV_snRNP	660..837	CDD:238840	142/176 (81%)
		eEF2_C_snRNP	832..911	CDD:239765	55/78 (71%)
MEE5	NP_001321282.1	EFTUD2	4..118	CDD:406414	47/115 (41%)
MEE5	NP_001321282.1	FusA	131..968	CDD:357662	532/838 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	273	1.000	Domainoid score	I428
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3133
Inparanoid	1	1.050	1220	1.000	Inparanoid score	I19
OMA	1	1.010	-	-		QHG54470
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	1	1.000	-	-		FOG0004923
OrthoInspector	1	1.000	-	-		otm3374
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	1	1.100	-	-	LDO	PTHR42908
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2958
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840