Protein Alignment CG4849 and EFL1

DIOPT Version :9

• Sequence 1: NP_651605.1
• Gene: CG4849 / 43358
• FlyBaseID: FBgn0039566
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_001309774.1
• Gene: EFL1 / 79631
• HGNCID: 25789
• Length: 1120
• Species: Homo sapiens
• Alignment Length: 1105
• Identity: 277/1105 - (25%)
• Similarity: 459/1105 - (41%)
• Gaps: 286/1105 - (25%)

  Fly   118 MEFMADLMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQERGCS 182
            ::.|..|......|||:.::.|:.|||||..|||| .::....:....:|||.|:...||.||.:
Human     6 LDKMIQLQKNTANIRNICVLAHVDHGKTTLADCLI-SSNGIISSRLAGKLRYMDSREDEQIRGIT 69

  Fly   183 IKATPVTLVLQDVKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKH 247
            :|::.::|... ...:.||:|:.|:||||:||.|.:.|:|:.||.::.:||.|||...|:.:|:.
Human    70 MKSSAISLHYA-TGNEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQ 133

  Fly   248 AVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTY------------------ 294
            |..|.....:.||||||||:|||..||:||..||:|:|::|.|..|.
Human   134 AWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAERETESQV 198

  Fly   295 ------------------GAPDDNLLVSPILGNVCFASSLYGFCFTLKSFAKLYADTYEGVAYLD 341
                              ...|.:|..||..|||.|.|::.|:.|.::.||::|:... |:....
Human   199 NPNSEQGEQVYDWSTGLEDTDDSHLYFSPEQGNVVFTSAIDGWGFGIEHFARIYSQKI-GIKKEV 262

  Fly   342 FAKRLWGDMYFNSKTRKFSKKQPHNSAQRSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRV 406
            ..|.||||.|.|.|.:|..|.......:..||:.|||.::.|...|:......:...:..|.:::
Human   263 LMKTLWGDYYINMKAKKIMKGDQAKGKKPLFVQLILENIWSLYDAVLKKDKDKIDKIVTSLGLKI 327

  Fly   407 -SKEEMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIY-TG--------PKE 461
             ::|...|:.:..:..:|::::......:.|..:.:.|||:....:|:.:. ||        |:.
Human   328 GAREARHSDPKVQINAICSQWLPISHAVLAMVCQKLPSPLDITAERVERLMCTGSQTFDSFPPET 392

  Fly   462 GDIYRDMISCNQYGT--LMVHSSKMY--------------------------------------- 485
            ..:....:.|....|  :::..|||:
Human   393 QALKAAFMKCGSEDTAPVIIFVSKMFAVDAKALPQNKPRPLTQEEIAQRRERARQRHAEKLAAAQ 457

  Fly   486 ------PNDD------C----------------------------TFFQVLARIVSGTLHAGQEV 510
                  |..|      |                            ..|...||:.||....|:::
Human   458 GQAPLEPTQDGSAIETCPKGEEPRGDEQQVESMTPKPVLQEENNQESFIAFARVFSGVARRGKKI 522

  Fly   511 RVLGENYTLQDEEDSRILQVG--------------------RLWVFESRYKVELNRVPAGNWVLI 555
            .|||..|:  ..|..|.:.:|                    .|::...|....|..||.||.:.|
Human   523 FVLGPKYS--PLEFLRRVPLGFSAPPDGLPQVPHMAYCALENLYLLMGRELEYLEEVPPGNVLGI 585

  Fly   556 EGIDQCIVKTSTIVDI-NVPEDLYIFRPLKFNTQSIIKIAVEPVNPSELPKMLDGLRKVNKSYPL 619
            .|:...::|::|:..: :.|.    |.||.|....|:::||||.:|||:|:::.|::.:|::.|.
Human   586 GGLQDFVLKSATLCSLPSCPP----FIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPC 646

  Fly   620 LSTRVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFCETVVETSSLKCFAETPNK 684
            :...::|:||||::..||::|...:.||::.:::|.|.|::|::.|.||:.:...:....|...|
Human   647 VQILIQETGEHVLVTAGEVHLQRCLDDLKERFAKIHISVSEPIIPFRETITKPPKVDMVNEEIGK 711

  Fly   685 KNKITMISEPLE------KGLAEDIENGTVCINWNKK-------------RIGEFFQVNYD---- 726
            :.|:.:|.:..|      :|:..| .:|.:.|....|             .:.:..:.|.|
Human   712 QQKVAVIHQMKEDQSKIPEGIQVD-SDGLITITTPNKLATLSVRAMPLPEEVTQILEENSDLIRS 775

  Fly   727 -------------------------WDL-------LAAR-------SIWAFGPDSTGPNILVDD- 751
                                     |:.       |..|       .||:|||...||||||:.
Human   776 MEQLTSSLNEGENTHMIHQKTQEKIWEFKGKLEQHLTGRRWRNIVDQIWSFGPRKCGPNILVNKS 840

  Fly   752 --------TLPSEVDKNLLTAVKD---SIVQGFQWGTREGPLCEEPIRNVKF------------- 792
                    |.|::......:..:|   |||.|||..|..||:||||:..|.|
Human   841 EDFQNSVWTGPADKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLSKFEEQ 905

  Fly   793 -------------KILDGVIANEALHRG------------------------GGQIIPTARRVAY 820
                         :...|...|:.|..|                        .||:|.|.:....
Human   906 GASDLAKEGQEENETCSGGNENQELQDGCSEAFEKRTSQKGESPLTDCYGPFSGQLIATMKEACR 970

  Fly   821 SAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQDAPVSGSPIYTIKAFIPAIDSFG 885
            .|..:...|||......::.|..|.:..||.||::|.|.|.|:....|:.::.|||.:|..:|||
Human   971 YALQVKPQRLMAAMYTCDIMATGDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFG 1035

  Fly   886 FETDLRTHTQGQAFCLSVFHHWQIVPGDPL----DKSIIIRPLEPQQASHLAREFMIKTRRRKGL 946
            |..::|..|.|.|....||.||:|:|.||.    .:...:...|...:.:.||::|...|:||||
Human  1036 FADEIRKRTSGLASPQLVFSHWEIIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGL 1100

  Fly   947  946
            Human  1101  1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	277/1105 (25%)
		Snu114p	132..340	CDD:206730	83/243 (34%)
		Translation_Factor_II_like	477..568	CDD:295476	29/189 (15%)
		snRNP_III	589..660	CDD:293921	25/70 (36%)
		EF2_IV_snRNP	660..837	CDD:238840	60/300 (20%)
		eEF2_C_snRNP	832..911	CDD:239765	28/78 (36%)
EFL1	NP_001309774.1	FusA	1..1103	CDD:357662	277/1105 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	430..496		3/65 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	907..930		2/22 (9%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820