DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4849 and eef2a.2

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001038637.1	Gene:	eef2a.2 / 568904	ZFINID:	ZDB-GENE-050208-348	Length:	853	Species:	Danio rerio

Alignment Length:	876	Identity:	317/876 - (36%)
Similarity:	501/876 - (57%)	Gaps:	62/876 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 YDMEFMADLMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQERG 180
            ::::.:...||....|||::::|...|||:|..|.|:.:. ....:....:.|:.||...||||.
Zfish     4 FNVDQIRATMDKKSNIRNMSVIGAFDHGKSTLTDWLVSKA-GIVSSACAGETRFMDTRRDEQERC 67

  Fly   181 CSIKATPVTL----------VLQDVKQKS-YLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAA 234
            .:||:|.:::          .:::.|..| :|||:.|:||||:||.|.|||:|::||.:|.:|..
Zfish    68 ITIKSTAISIFYELADKDLAFIKECKDGSGFLLNLIDSPGHVDFSSEVTAALRITDGALLVVDCV 132

  Fly   235 EGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYG---- 295
            .||.|.||.:|:.|:.||....:.|||:||.:|||:|.|::.|...:.|||:||..:|||.
Zfish   133 SGVCLQTETVLRQAIGERIKPVLMINKMDRALLELQLVPEELYQIFQRIVEKVNVTISTYAEDEK 197

  Fly   296 APDDNLLVSPILGNVCFASSLYGFCFTLKSFAKLYADTYEGVAYL----------DFAKRLWGDM 350
            .|..|:::.|::||:.|.|.|:|:.||||.||:||...:.|.|.|          |..|:|||:.
Zfish   198 GPMGNVMIDPVVGNLAFGSGLHGWAFTLKQFAELYVKKFAGKAQLRPEEYIKKVEDMMKKLWGNS 262

  Fly   351 YFNSKTRKFS--------KKQPHNSAQRSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRVS 407
            ||:|.|.|||        ||.|     |:||:.:|:|::|:...::.......:..:.::.:::.
Zfish   263 YFDSTTGKFSESATSPNGKKLP-----RTFVQLVLDPIFKVFDAIMNFKKEETAKLIEKMGIKLD 322

  Fly   408 KEEMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMISCN 472
            .||.|...:.||:.|..|::......:.|...|:.||:.....:.:.:|.||.:.:....:.:|:
Zfish   323 AEEEKMEGKLLLKAVMRRWLQAGEALLQMITIHLPSPVTAQIYRCELLYEGPGDDEAAMGIKNCD 387

  Fly   473 QYGTLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWVFE 537
            ....||::.|||.|..|...|....|:.||.:..|..||::|.|:|...::|..:..:.|..:..
Zfish   388 PKAPLMMYISKMVPTSDKGCFYAFGRVFSGCVSTGLNVRIMGPNFTPGKKDDLYLKPIQRTVLMM 452

  Fly   538 SRYKVELNRVPAGNWVLIEGIDQCIVKTSTIVDINVPEDLYIFRPLKFNTQSIIKIAVEPVNPSE 602
            .||...:..||.||.|.:.|:|..:|||.||....   ..|..|.:||:...:::::||.::|::
Zfish   453 GRYVEPIEDVPCGNIVGLLGVDLFLVKTGTITTFT---KAYNMRVMKFSVSPVVRVSVEVMDPAD 514

  Fly   603 LPKMLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFCE 667
            |||:::||:.:.||.|:|....|:||||:|.|.|||:|:..:.||.:::.   :|.:|....:.|
Zfish   515 LPKLVEGLKHLAKSDPMLQCIFEDSGEHIIAGAGELHLEICLKDLEEVHG---LKKSDLFATYRE 576

  Fly   668 TVVETSSLKCFAETPNKKNKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLLAA 732
            ||.:.|...|.|:|||:::::...:.||..||||||:.|.|..:.......::...||.|::..|
Zfish   577 TVSDGSKKMCLAKTPNQQSRLFFKACPLADGLAEDIDKGRVTASQEMNARAQYLAENYKWEVTEA 641

  Fly   733 RSIWAFGPDSTGPNILVDDTLPSEVDKNLLTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILDG 797
            |.||.|||:.||||||||  |...|  ..|..:|||::.||||.||||.||.|.:|.::|.|.|.
Zfish   642 RKIWCFGPEGTGPNILVD--LTKRV--QYLNEIKDSVIAGFQWVTREGILCAENMRGIRFDIHDA 702

  Fly   798 VIANEALHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQ 862
            .:.:.|:|||.||:|...|||.|...|.|.|||.||...||:|.|...:..::.||.:|||.|..
Zfish   703 TLTSTAIHRGPGQVITATRRVLYGCQLTAEPRLSEPVYLVEMQCPESVIGIIHAVLVKRRGVVFL 767

  Fly   863 DAPVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIIRPLEPQ 927
            ::.|:|:|||.:||::|..:||||..||..:|.||||...||.||||:|||||:.:        .
Zfish   768 ESQVTGTPIYLLKAYLPVSESFGFTADLCANTSGQAFSQCVFDHWQIMPGDPLNTT--------S 824

  Fly   928 QASHLAREFMIKTRRRKGLSE-DVSINKFFD 957
            :.:|:    |...|:||||.| ::::::|.|
Zfish   825 KTAHI----MADIRKRKGLPEANLALHRFLD 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	316/874 (36%)
		Snu114p	132..340	CDD:206730	87/222 (39%)
		Translation_Factor_II_like	477..568	CDD:295476	31/90 (34%)
		snRNP_III	589..660	CDD:293921	26/70 (37%)
		EF2_IV_snRNP	660..837	CDD:238840	77/176 (44%)
		eEF2_C_snRNP	832..911	CDD:239765	37/78 (47%)
eef2a.2	NP_001038637.1	PTZ00416	1..852	CDD:240409	317/876 (36%)
		EF2	20..233	CDD:206672	84/213 (39%)
		Translation_Factor_II_like	392..486	CDD:295476	33/93 (35%)
		EF2_snRNP_III	511..563	CDD:293918	23/51 (45%)
		aeEF2_snRNP_like_IV	573..741	CDD:238839	76/171 (44%)
		eEF2_snRNP_like_C	737..816	CDD:239763	37/78 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720