DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4849 and gfm1

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001073463.1	Gene:	gfm1 / 561840	ZFINID:	ZDB-GENE-061013-79	Length:	745	Species:	Danio rerio

Alignment Length:	829	Identity:	188/829 - (22%)
Similarity:	320/829 - (38%)	Gaps:	227/829 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 IRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYT-------------------DTLFTE 176
            |||:.:..|:..|||               |:.||.|.||                   |::..|
Zfish    41 IRNIGISAHIDSGKT---------------TLTERVLYYTGRIAEMHEVRGKDGVGAIMDSMELE 90

  Fly   177 QERGCSIK-ATPVTLVLQDVKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLN 240
            ::||.:|: |...|:      .|::.:||.||||||:|:.|...::|:.||.||.:.|..||...
Zfish    91 RQRGITIQSAATYTM------WKNHNINIIDTPGHVDFTIEVERSLRVLDGAVLVLCAVGGVQCQ 149

  Fly   241 TERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYGAPDDNLLVSP 305
            |..:.:...:........|||:|||........|....||......||..:...|
Zfish   150 TVTVNRQMKRYSVPFLTFINKLDRLGANPNRALQQLRTKLNQNAAFVNIPIGLEG---------- 204

  Fly   306 ILGNVCFASSLYGFCFTLKSFAKLYADTY-EGVAYLDFAKRLWGDMYFNSKTRKFSKKQPHNSAQ 369
                     :|.|....::..:.::...: |.|.|.|....:        ::....::|.
Zfish   205 ---------NLRGIIDLIEERSIVFDGPFGESVRYEDIPPEM--------RSEAADRRQE----- 247

  Fly   370 RSFVEFILEPMYKLIAQVVGDVDTTLSD--------TLAELNVRVSKEEMKSNIRPLLRLVCNRF 426
                          :.:.|.:.|.||.:        |:.:|...|.:..:|.:..|:|
Zfish   248 --------------LVECVANADETLGEMFLEERVPTVLDLKAAVRRATVKRSFSPVL------- 291

  Fly   427 MGDC------SGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMISCNQYGTLMVHSSKMY 485
            :|..      ...:|..:|::.:|.|     |.:.....:||:        ::...:::.|::
Zfish   292 VGSALKNKGVQPLLDAVLEYLPNPTE-----VQNYAILNEEGE--------SEGSKILMDSTR-- 341

  Fly   486 PNDDCTFFQVLA-RIVSGTLHAGQEVRV----LGENYTLQDEEDSRILQVGRLWVFESRYKVELN 545
              ||...|..|| ::.:|.......|||    |.:...:.:....|.::|.||....:....::.
Zfish   342 --DDTQPFVGLAFKLEAGRFGQLTYVRVYQGCLRKTDYIHNSRTGRRVRVQRLVRLHADQMEDVE 404

  Fly   546 RVPAGNWVLIEGIDQCIVKTST--------IVDINVPEDLYIFRPLKFNTQSIIKIAVEPVNPSE 602
            ...||:...:.|||.....|.|        :..|:|||             .:|.:|:.|.|.::
Zfish   405 VAYAGDICALFGIDCASGDTFTARNNANLSMESIHVPE-------------PVISMAIRPSNKND 456

  Fly   603 LPKMLDGLRKVNKSYPLLSTRVE-ESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFC 666
            ..|:..|:.:..:..|......: ||.|.:|.|.|||:|:.....:.:.|| ....:..|.|||.
Zfish   457 TDKLSKGISRFTREDPTFRVHFDTESKETIISGMGELHLEIYSQRMEREYS-CPCVMGKPKVAFR 520

  Fly   667 ETVVETSSLKCFAETPNKKN-------KITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVN 724
            ||:  ||::. |..|..|::       |:..:.|||      |.||.|              :|.
Zfish   521 ETL--TSAVP-FEYTHKKQSGGSGQYGKVIGVLEPL------DSENYT--------------KVE 562

  Fly   725 YDWDLLAARSIWAFGPDSTGPNILVDDTLPSEVDKNLLTAVKDSIVQGFQWGTREGPLCEEPIRN 789
            :.                       |:|:.:.:.|..:.||:    :||:....:|||....|..
Zfish   563 FS-----------------------DETVGTNIPKQFVPAVE----KGFRDACEKGPLIGHKISG 600

  Fly   790 VKFKILDG----VIANEA--LHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSA 848
            |:|.:.||    |.:||.  :..|.|.:        ..|...||..::||.:.||:.||.:...|
Zfish   601 VRFVLEDGAHHMVDSNEISFIRAGEGAV--------KQALEKATVVILEPVMSVEIVAPNEFQGA 657

  Fly   849 VYTVLARRRGHVTQDAPVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQ 897
            |...:.||.|.::......|  .:|:.|.||..|.||:.|:||:.|:|:
Zfish   658 VIAGVNRRHGVISGQDGADG--YFTLYADIPLNDMFGYATELRSCTEGK 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	188/829 (23%)
		Snu114p	132..340	CDD:206730	55/228 (24%)
		Translation_Factor_II_like	477..568	CDD:295476	22/103 (21%)
		snRNP_III	589..660	CDD:293921	18/71 (25%)
		EF2_IV_snRNP	660..837	CDD:238840	45/189 (24%)
		eEF2_C_snRNP	832..911	CDD:239765	24/66 (36%)
gfm1	NP_001073463.1	EF-G	43..315	CDD:206673	70/345 (20%)
		PRK12740	47..726	CDD:237186	185/823 (22%)
		mtEFG1_II_like	347..427	CDD:293908	18/79 (23%)
		EFG_III	441..516	CDD:293919	20/88 (23%)
		EFG_mtEFG1_IV	519..635	CDD:238715	38/173 (22%)
		mtEFG1_C	641..718	CDD:239764	24/66 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810