DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4849 and eef2.2

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001015785.1	Gene:	eef2.2 / 548502	XenbaseID:	XB-GENE-5771153	Length:	859	Species:	Xenopus tropicalis

Alignment Length:	880	Identity:	344/880 - (39%)
Similarity:	522/880 - (59%)	Gaps:	64/880 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 MEFMAD----LMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQE 178
            :.|..|    :||....|||::::.|:.|||:|..|.|:.:. ....:....:.|:|||...|||
Frog     2 VNFTVDQIRAIMDKKSNIRNMSVIAHVDHGKSTLTDSLVCKA-GIIASARAGETRFTDTRKDEQE 65

  Fly   179 RGCSIKATPVTLV-------LQDVKQ----KSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFID 232
            |..:||:|.::|.       |..:||    ..:|:|:.|:||||:||.|.|||:|::||.::.:|
Frog    66 RCITIKSTAISLYYELSENDLAFIKQCKEGSGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVD 130

  Fly   233 AAEGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYG-- 295
            ...||.:.||.:|:.|:.||....:.:||:||.:|||:|.|::.|...:.|||.||.::||||
Frog   131 CVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYLTFQRIVENVNVIISTYGEG 195

  Fly   296 --APDDNLLVSPILGNVCFASSLYGFCFTLKSFAKLY---------------ADTYEGVAYLDFA 343
              .|..|:::.|::|.|.|.|.|:|:.||||.||::|               ||..:.|.  |..
Frog   196 ESGPMGNIMIDPVIGTVGFGSGLHGWAFTLKQFAEMYVAKFASKGEKTKLNPADRAKKVE--DMM 258

  Fly   344 KRLWGDMYFNSKTRKFSKKQPHNSAQ---RSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVR 405
            |:||||.||:..|.||||...:...:   |:|.:.||:|::|:...::.......:..:.:|:::
Frog   259 KKLWGDKYFDPSTGKFSKTATNAEGKKLPRTFSQLILDPIFKIFDAIMNFKKEETAKLIEKLDIK 323

  Fly   406 VSKEEMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMIS 470
            :..|:.:...:|||:.|..|::......:.|...|:.||:...|.:.:.:|.||.:.:....:.|
Frog   324 LDTEDKEKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAALGVKS 388

  Fly   471 CNQYGTLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWV 535
            |:..|.|:::.|||.|..|...|....|:.||.:..||:||::|.|||...:||..:..:.|..:
Frog   389 CDPKGPLVMYISKMVPTSDKGRFYAFGRVFSGIVSTGQKVRIMGPNYTPGKKEDLYLKPIQRTIL 453

  Fly   536 FESRYKVELNRVPAGNWVLIEGIDQCIVKTSTIVDINVPEDLYIFRPLKFNTQSIIKIAVEPVNP 600
            ...||...:..||.||.|.:.|:||.:|||.||...   |..:..|.:||:...::::|||..||
Frog   454 MMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTF---EHAHNMRVMKFSVSPVVRVAVEAKNP 515

  Fly   601 SELPKMLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAF 665
            ::|||:::||:::.||.|::...:||||||:|.|.|||:|:..:.||.:.::.|.:|.:||||::
Frog   516 ADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSY 580

  Fly   666 CETVVETSSLKCFAETPNKKNKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLL 730
            .|||.|.||..|.:::|||.|::.|.:.|...||||||:.|.|......|:...:....|:||:.
Frog   581 RETVSEESSQLCLSKSPNKHNRLFMKARPFPDGLAEDIDKGDVSSRQELKQRARYLAEKYEWDVA 645

  Fly   731 AARSIWAFGPDSTGPNILVDDTLPSEVDKNL--LTAVKDSIVQGFQWGTREGPLCEEPIRNVKFK 793
            .||.||.||||.||||||||      |.|.:  |..:|||:|.||||.|:||.||||.:|..:|.
Frog   646 EARKIWCFGPDGTGPNILVD------VTKGVQYLNEIKDSVVAGFQWATKEGVLCEENLRGARFD 704

  Fly   794 ILDGVIANEALHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRG 858
            |.|..:..:|:||||||||||||||.|::.|.|.||||||...||:|.|...|..:|.||.|:||
Frog   705 IHDVTLHADAIHRGGGQIIPTARRVLYASALTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRG 769

  Fly   859 HVTQDAPVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIIRP 923
            ||.:::.|:|:|::.:||::|..:||||..|||::|.||||...||.||||:||||.|.:  .||
Frog   770 HVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDST--SRP 832

  Fly   924 LEPQQASHLAREFMIKTRRRKGLSEDV-SINKFFD 957
                  |.:..|    ||:||||.|.: .::.|.|
Frog   833 ------SQVVGE----TRKRKGLKEGIPPLDNFLD 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	343/878 (39%)
		Snu114p	132..340	CDD:206730	87/237 (37%)
		Translation_Factor_II_like	477..568	CDD:295476	34/90 (38%)
		snRNP_III	589..660	CDD:293921	29/70 (41%)
		EF2_IV_snRNP	660..837	CDD:238840	91/178 (51%)
		eEF2_C_snRNP	832..911	CDD:239765	39/78 (50%)
eef2.2	NP_001015785.1	PTZ00416	1..859	CDD:240409	344/880 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920