DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4849 and eef2.1

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_989255.1	Gene:	eef2.1 / 394866	XenbaseID:	XB-GENE-969739	Length:	858	Species:	Xenopus tropicalis

Alignment Length:	875	Identity:	334/875 - (38%)
Similarity:	517/875 - (59%)	Gaps:	55/875 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 YDMEFMADLMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQERG 180
            :.::.:..:||....|||::::.|:.|||:|..|.|:.:. ....:....:.|:|||...||||.
Frog     4 FTVDQIRSIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKA-GIIASARAGETRFTDTRKDEQERC 67

  Fly   181 CSIKATPVTLV-------LQDVKQK----SYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAA 234
            .:||:|.::|.       |..:||.    .:|:|:.|:||||:||.|.|||:|::||.::.:|..
Frog    68 ITIKSTAISLFYELSENDLAFIKQSKDGCGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCV 132

  Fly   235 EGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYG---- 295
            .||.:.||.:|:.|:.||....:.:||:||.:|||:|.|::.|...:.|||.||.::||||
Frog   133 SGVCVQTETVLRQAIAERIRPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGET 197

  Fly   296 APDDNLLVSPILGNVCFASSLYGFCFTLKSFAKLYADTY--EGVAYL----------DFAKRLWG 348
            .|..|:::.|:||.|.|.|.|:|:.||||.||::|...:  :|...|          |..|:|||
Frog   198 GPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLAPAERAKKVEDMMKKLWG 262

  Fly   349 DMYFNSKTRKFSKKQPHNSAQ---RSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRVSKEE 410
            |.||:....||||...:...:   |:|.:.:|:|::|:...::.......:..:.:|::::..|:
Frog   263 DRYFDPANGKFSKSATNADGKKLPRTFCQLVLDPIFKVFDAIMNFKKEETAKLVEKLDIKLDSED 327

  Fly   411 MKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMISCNQYG 475
            .....:.||:.|..|::......:.|...|:.||:...|.:.:.:|.||.:.:....:.:|:..|
Frog   328 KDKEGKQLLKAVMRRWLPAGEALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKNCDPKG 392

  Fly   476 TLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWVFESRY 540
            .||::.|||.|..|...|....|:.||.:..|.:||::|.|:|...:||..:..:.|..:...||
Frog   393 PLMMYISKMVPTTDKGRFYAFGRVFSGVVSTGLKVRIMGPNFTPGKKEDLYLKPIQRTILMMGRY 457

  Fly   541 KVELNRVPAGNWVLIEGIDQCIVKTSTIVDINVPEDLYIFRPLKFNTQSIIKIAVEPVNPSELPK 605
            ...:..||.||.|.:.|:||.:|||.||...   |..:..|.:||:...::::|||..||::|||
Frog   458 VEPIEDVPCGNIVGLVGVDQFLVKTGTITTF---EHSHNMRVMKFSVSPVVRVAVEAKNPADLPK 519

  Fly   606 MLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFCETVV 670
            :::||:::.||.|::...:||||||:|.|.|||:|:..:.||.:.::.|.||.:||||::.|||.
Frog   520 LVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVS 584

  Fly   671 ETSSLKCFAETPNKKNKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLLAARSI 735
            |.|:..|.:::|||.|::.|...|...||||||:.|.|......|....:....|:||:..||.|
Frog   585 EESNQMCLSKSPNKHNRLFMKCRPFPDGLAEDIDKGDVSARQELKTRARYLAEKYEWDVTEARKI 649

  Fly   736 WAFGPDSTGPNILVDDTLPSEVDKNL--LTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILDGV 798
            |.||||.:|||||.|      |.|.:  |..:|||:|.||||.|:||.||||.:|.|:|.:.|..
Frog   650 WCFGPDGSGPNILTD------VTKGVQYLNEIKDSVVAGFQWATKEGVLCEENLRGVRFDVHDVT 708

  Fly   799 IANEALHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQD 863
            :..:|:||||||||||||||.|:..|.|.||||||...||:|.|...|..:|.||.|:||||.::
Frog   709 LHADAIHRGGGQIIPTARRVLYACVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEE 773

  Fly   864 APVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIIRPLEPQQ 928
            :.|:|:|::.:||::|..:||||..|||::|.||||...||.||||:||||.|.:  .||.
Frog   774 SQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNT--TRPF---- 832

  Fly   929 ASHLAREFMIKTRRRKGLSEDV-SINKFFD 957
                  :.:.:||:||||.|.| :::.|.|
Frog   833 ------QVVAETRKRKGLKEGVQALDNFLD 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	333/873 (38%)
		Snu114p	132..340	CDD:206730	86/224 (38%)
		Translation_Factor_II_like	477..568	CDD:295476	33/90 (37%)
		snRNP_III	589..660	CDD:293921	30/70 (43%)
		EF2_IV_snRNP	660..837	CDD:238840	88/178 (49%)
		eEF2_C_snRNP	832..911	CDD:239765	39/78 (50%)
eef2.1	NP_989255.1	PTZ00416	1..858	CDD:240409	334/875 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010