DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4849 and eEF2

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	866	Identity:	320/866 - (36%)
Similarity:	513/866 - (59%)	Gaps:	51/866 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 YDMEFMADLMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQERG 180
            :.::.:..|||....|||::::.|:.|||:|..|.|:.:. ......:..:.|:|||...||||.
  Fly     4 FTVDEIRGLMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKA-GIIAGAKAGETRFTDTRKDEQERC 67

  Fly   181 CSIKATPVTLVLQ------------DVKQ---KSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLF 230
            .:||:|.:::..:            |.::   |.:|:|:.|:||||:||.|.|||:|::||.::.
  Fly    68 ITIKSTAISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGALVV 132

  Fly   231 IDAAEGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTY- 294
            :|...||.:.||.:|:.|:.||....:.:||:||.:|||:|..::.|...:.|||.||.:::||
  Fly   133 VDCVSGVCVQTETVLRQAIAERIKPILFMNKMDRALLELQLDAEELYQTFQRIVENVNVIIATYN 197

  Fly   295 --GAPDDNLLVSPILGNVCFASSLYGFCFTLKSFAKLYADTYEGVAYLDFAK---RLWGDMYFNS 354
              |.|...:.|.|..|:|.|.|.|:|:.||||.|:::|::.::    :|..|   ||||:.:||:
  Fly   198 DDGGPMGEVRVDPSKGSVGFGSGLHGWAFTLKQFSEMYSEKFK----IDVVKLMNRLWGENFFNA 258

  Fly   355 KTRKFSKKQPHNSAQRSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRVSKEEMKSNIRPLL 419
            ||:|: :||.....:|||..:||:|:||:...::......:...|.::.|.:..|:...:.:.||
  Fly   259 KTKKW-QKQKEADNKRSFCMYILDPIYKVFDAIMNYKKEEIGTLLEKIGVTLKHEDKDKDGKALL 322

  Fly   420 RLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMISCNQYGTLMVHSSKM 484
            :.|...::......:.|...|:.||:...|.:::.:|.||.:.:....:.||:..|.||::.|||
  Fly   323 KTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRMEMLYEGPHDDEAAIAVKSCDPDGPLMMYISKM 387

  Fly   485 YPNDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWVFESRYKVELNRVPA 549
            .|..|...|....|:.:|.:..||:.|::|.|||...:||.....:.|..:...||...:..||:
  Fly   388 VPTSDKGRFYAFGRVFAGKVATGQKCRIMGPNYTPGKKEDLYEKAIQRTILMMGRYVEAIEDVPS 452

  Fly   550 GNWVLIEGIDQCIVKTSTIVDINVPEDLYIFRPLKFNTQSIIKIAVEPVNPSELPKMLDGLRKVN 614
            ||...:.|:||.:|||.||...   :|.:..:.:||:...::::||||.||::|||:::||:::.
  Fly   453 GNICGLVGVDQFLVKTGTITTF---KDAHNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGLKRLA 514

  Fly   615 KSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFCETVVETSSLKCFA 679
            ||.|::...:||||||:|.|.|||:|:..:.||.:.::.|.:|.:||||::.|||.|.|...|.:
  Fly   515 KSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQMCLS 579

  Fly   680 ETPNKKNKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLLAARSIWAFGPDSTG 744
            ::|||.|::.|.:.|:..||.|||:||.|......|....:....||:|:..||.||.||||.||
  Fly   580 KSPNKHNRLLMKALPMPDGLPEDIDNGDVSAKDEFKARARYLSEKYDYDVTEARKIWCFGPDGTG 644

  Fly   745 PNILVDDTLPSEVDKNLLTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILDGVIANEALHRGGG 809
            ||.::|.|...:    .|..:|||:|.||||.::||.|.:|.:|.|:|.|.|..:..:|:|||||
  Fly   645 PNFILDCTKSVQ----YLNEIKDSVVAGFQWASKEGILADENLRGVRFNIYDVTLHADAIHRGGG 705

  Fly   810 QIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQDAPVSGSPIYTI 874
            |||||.||..|:|.:.|.||||||....|:|.|...|..:|.||.||||||.::..|.|:|::.:
  Fly   706 QIIPTTRRCLYAAAITAKPRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEENQVVGTPMFVV 770

  Fly   875 KAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIIRPLEPQQASHLAREFMI- 938
            ||::|..:||||..|||::|.||||...||.|||::||||.:.|              ::.:.|
  Fly   771 KAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPSEPS--------------SKPYAIV 821

  Fly   939 -KTRRRKGLSEDV-SINKFFD 957
             .||:||||.|.: .::::.|
  Fly   822 QDTRKRKGLKEGLPDLSQYLD 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	319/864 (37%)
		Snu114p	132..340	CDD:206730	79/225 (35%)
		Translation_Factor_II_like	477..568	CDD:295476	32/90 (36%)
		snRNP_III	589..660	CDD:293921	30/70 (43%)
		EF2_IV_snRNP	660..837	CDD:238840	82/176 (47%)
		eEF2_C_snRNP	832..911	CDD:239765	38/78 (49%)
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	320/866 (37%)
		EF2	20..236	CDD:206672	78/216 (36%)
		EF2_snRNP_like_II	380..474	CDD:293901	34/93 (37%)
		EF2_snRNP_III	489..560	CDD:293918	30/70 (43%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	82/175 (47%)
		eEF2_snRNP_like_C	728..807	CDD:239763	38/78 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464568
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11854at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	1	1.100	-	-	P	PTHR42908
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.750