DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4849 and eRF3

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001260415.1	Gene:	eRF3 / 34658	FlyBaseID:	FBgn0020443	Length:	619	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	97/471 - (20%)
Similarity:	163/471 - (34%)	Gaps:	133/471 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DPEDAMDEDEVEPQEDEDKEVTAVVLHEDKRYYPSAVEVYGPDVETIVQEEDAQPLDKPLIEPVK 100
            :|.|.:..:|.:|.:..|.: .||:..||:                  :.|||:..:......|.
  Fly   134 NPSDKIANNETDPADSWDVD-DAVITPEDE------------------EVEDAEFTEGEATPKVS 179

  Fly   101 KLKFQIKEQDMQETTYDMEFMADLMDTPPLIRNVALVGHLHHGKTT----------FVDCLIRQT 155
            |.|....|::..:..:               .||..:||:..||:|          .||   ::|
  Fly   180 KKKVVKVEENRSKREH---------------VNVVFIGHVDAGKSTIGGQIMSLTGMVD---KRT 226

  Fly   156 HPQFETMEERQLRYT-------DTLFTEQERGCSIKATPVTLVLQDVKQKSYLLNIFDTPGHVNF 213
            ..::|.....:.|.:       ||...|:::|   |...|.....:..:|.:  .|.|.|||.:|
  Fly   227 LEKYEREAREKSRESWYLSWALDTNQEERDKG---KTVEVGRAFFETDRKHF--TILDAPGHKSF 286

  Fly   214 SDEATAAMRMSDGVVLFIDAAEG---------------VMLNTERLLKHAVQERQAITVCINKID 263
            ..........:|..||.|.|.:|               .||.....:||.|       |.:||:|
  Fly   287 VPNMIGGAAQADLAVLVISARKGEFETGFDRGGQTREHAMLAKTAGVKHLV-------VLVNKMD 344

  Fly   264 RLILELKLPPQDAYFKLKHIVEEVNGLLSTYG-APDDNLLVSPILGNVCFASSLYGFCFTLK-SF 326
            ...:..   .|..|.:.|   :::...|...| .|..:|...|     |...|.||    || ..
  Fly   345 DPTVNW---DQTRYNECK---DKILPYLKKLGFNPAKDLTFMP-----CSGLSGYG----LKDQI 394

  Fly   327 AKLYADTYEGVAYLDFAKRLWGDMYFNSKTRKFSKKQPHNSAQRSFVEFILEPMYKLIAQVVGDV 391
            .:.....|.|.|::.|...|      .|..||         :...|:..|::....:...|:|.|
  Fly   395 PETLCPWYRGPAFIPFIDEL------PSLNRK---------SDGPFIMPIVDKYKDMGTVVMGKV 444

  Fly   392 DTTLSDTLAELNVRVSKEEMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIY 456
            ::..:.....|.|..::.:          :..::...|     |..|..: .|.||.|.|:
  Fly   445 ESGTARKGQNLLVMPNRTQ----------VAVDQLFSD-----DFEVTSV-GPGENVKIKL---- 489

  Fly   457 TGPKEGDIYRDMISCN 472
            .|.:|.|:....:.|:
  Fly   490 KGIEEEDVSPGFVLCD 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623	16/74 (22%)
		PTZ00416	115..957	CDD:240409	81/392 (21%)
		Snu114p	132..340	CDD:206730	57/241 (24%)
		Translation_Factor_II_like	477..568	CDD:295476
		snRNP_III	589..660	CDD:293921
		EF2_IV_snRNP	660..837	CDD:238840
		eEF2_C_snRNP	832..911	CDD:239765
eRF3	NP_001260415.1	PAM2	12..28	CDD:284542
		TEF1	191..619	CDD:227581	81/395 (21%)
		EF1_alpha	197..416	CDD:206670	59/254 (23%)
		eRF3_II	424..505	CDD:293906	18/100 (18%)
		eRF3_C_III	511..617	CDD:294003
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464572
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930