DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4849 and eef2l2

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_021332246.1	Gene:	eef2l2 / 336168	ZFINID:	ZDB-GENE-030131-8112	Length:	861	Species:	Danio rerio

Alignment Length:	878	Identity:	333/878 - (37%)
Similarity:	518/878 - (58%)	Gaps:	58/878 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 YDMEFMADLMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQERG 180
            :.::.:.::||....|||::::.|:.|||:|..|.|:.:. ....:....:.|:|||...||||.
Zfish     4 FTVDQIREIMDKKSNIRNMSVIAHVDHGKSTLTDSLVCKA-GIIASARAGETRFTDTRKDEQERC 67

  Fly   181 CSIKATPVTLVLQ-------DVKQ----KSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAA 234
            .:||:|.::|..:       .:||    ..:|:|:.|:||||:||.|.|||:|::||.::.:|..
Zfish    68 ITIKSTAISLYYELSENDSAFIKQCKDGSGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCV 132

  Fly   235 EGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYG---- 295
            .||.:.||.:|:.|:.||....:.:||:||.:|||:|.|.:.:...:.|||.||.::||||
Zfish   133 SGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPDELFQTFQRIVENVNVIISTYGEGEH 197

  Fly   296 APDDNLLVSPILGNVCFASSLYGFCFTLKSFAKLY-------ADTYEG--------VAYLDFAKR 345
            .|..|::|.|::|.|.|.|.|:|:.||||.||::|       .|..:|        ....:..|:
Zfish   198 GPMGNIMVDPVIGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGDKKKGDLPPAERAKKVEEMMKK 262

  Fly   346 LWGDMYFNSKTRKFSKKQPHNSAQ-----RSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVR 405
            ||||.||:....||||..  |:|.     |:|.:.:|:|::|:...::..........:.:|.|:
Zfish   263 LWGDKYFDPSCGKFSKTA--NNADGKKLPRTFCQLVLDPIFKVFDAIMNFKKEETQKLIEKLEVK 325

  Fly   406 VSKEEMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMIS 470
            :..|:.:...:|||:.|..|::......:.|...|:.||:...:.:.:.:|.||.:.:....:.:
Zfish   326 LDAEDKEKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQRYRCELLYEGPGDDEAAMGIKN 390

  Fly   471 CNQYGTLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWV 535
            |:....||::.|||.|..|...|....|:.||.:..||:||::|.|:|...:||..:..:.|..:
Zfish   391 CDPKAPLMMYISKMVPTTDKGRFYAFGRVFSGIVSTGQKVRIMGPNFTPGKKEDLYLKPIQRTIL 455

  Fly   536 FESRYKVELNRVPAGNWVLIEGIDQCIVKTSTIVDINVPEDLYIFRPLKFNTQSIIKIAVEPVNP 600
            ...||...:..||.||.|.:.|:||.:|||.||...   |:.:..|.:||:...::::|||..||
Zfish   456 MMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTF---ENSHNMRVMKFSVSPVVRVAVEAKNP 517

  Fly   601 SELPKMLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAF 665
            ::|||:::||:::.||.|::...:||||||::.|.|||:|:..:.||.:.::.|.:|.:||||::
Zfish   518 ADLPKLVEGLKRLAKSDPMVQCIIEESGEHIVAGAGELHLEICLKDLEEDHACIPLKKSDPVVSY 582

  Fly   666 CETVVETSSLKCFAETPNKKNKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLL 730
            .|||.:.|...|.:::|||.|::.|.|.|...||||||:.|.|......|....:....|:|::.
Zfish   583 RETVSDESDQVCLSKSPNKHNRLYMKSRPFPDGLAEDIDKGDVSSRQELKLRARYLAEKYEWEVA 647

  Fly   731 AARSIWAFGPDSTGPNILVDDTLPSEVDKNLLTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKIL 795
            .||.||.||||.||||||||.|...:    .|..:|||:|.||||.|:||.||||.:|.|:|.|.
Zfish   648 EARKIWCFGPDGTGPNILVDITKGVQ----YLNEIKDSVVAGFQWATKEGALCEENMRAVRFDIH 708

  Fly   796 DGVIANEALHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHV 860
            |..:..:|:||||||||||||||.|::.|.|.||||||...||:|.|...|..:|.||.|:||||
Zfish   709 DVTLHADAIHRGGGQIIPTARRVLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHV 773

  Fly   861 TQDAPVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIIRPLE 925
            .:::.|:|:||:.:||::|..:||||..|||::|.||||...||.||||:||||.|.:     .:
Zfish   774 FEESQVAGTPIFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPYDVN-----SK 833

  Fly   926 PQQASHLAREFMIKTRRRKGLSEDV-SINKFFD 957
            |.|       .:..||:||||.|.: :::.|.|
Zfish   834 PSQ-------IVADTRKRKGLKEGIPALDNFLD 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	332/876 (38%)
		Snu114p	132..340	CDD:206730	85/237 (36%)
		Translation_Factor_II_like	477..568	CDD:295476	34/90 (38%)
		snRNP_III	589..660	CDD:293921	28/70 (40%)
		EF2_IV_snRNP	660..837	CDD:238840	89/176 (51%)
		eEF2_C_snRNP	832..911	CDD:239765	40/78 (51%)
eef2l2	XP_021332246.1	PTZ00416	1..861	CDD:240409	333/878 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720