DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4849 and eef2b

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_956752.2	Gene:	eef2b / 326929	ZFINID:	ZDB-GENE-030131-5128	Length:	858	Species:	Danio rerio

Alignment Length:	882	Identity:	335/882 - (37%)
Similarity:	516/882 - (58%)	Gaps:	69/882 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 MEFMAD----LMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQE 178
            :.|..|    :||....|||::::.|:.|||:|..|.|:.:. ....:....:.|:|||...|||
Zfish     2 VNFTVDQIRAIMDKKSNIRNMSVIAHVDHGKSTLTDSLVSKA-GIIASARAGETRFTDTRKDEQE 65

  Fly   179 RGCSIKATPVTLV-------LQDVKQ----KSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFID 232
            |..:||:|.:::.       |..:||    ..:|:|:.|:||||:||.|.|||:|::||.::.:|
Zfish    66 RCITIKSTAISMYYELTENDLAFIKQCKDGSGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVD 130

  Fly   233 AAEGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTY--- 294
            ...||.:.||.:|:.|:.||....:.:||:||.:|||:|.|::.|...:.|||.||.::|||
Zfish   131 CVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGED 195

  Fly   295 -GAPDDNLLVSPILGNVCFASSLYGFCFTLKSFAKLYADTY--EGVAYL----------DFAKRL 346
             |.|..|:::.|::|.|.|.|.|:|:.||||.||::|...:  :|.|.|          |..|:|
Zfish   196 EGGPMGNIMIDPVIGTVGFGSGLHGWAFTLKQFAEMYVAKFASKGEAQLSPADRCKKVEDMMKKL 260

  Fly   347 WGDMYFNSKTRKFS--------KKQPHNSAQRSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELN 403
            |||.||:....||:        ||.|     |:|.:.||:|::|:...::.......:..:.:|:
Zfish   261 WGDRYFDPAGGKFTKTANGPDGKKYP-----RTFAQLILDPIFKVFDAIMNFKKEETAKLIEKLD 320

  Fly   404 VRVSKEEMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDM 468
            :::..|:.....:|||:.|..|::......:.|...|:.||:...|.:.:.:|.||.:.:....:
Zfish   321 IKLDTEDKDKEGKPLLKAVMRRWLPAGEALLQMITIHLPSPVTAQKYRCELLYEGPGDDEAAMGI 385

  Fly   469 ISCNQYGTLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRL 533
            .:|:..|.||::.|||.|..|...|....|:.||.:..|.:||::|.|||...:||..:..:.|.
Zfish   386 KNCDPKGPLMMYISKMVPTTDKGRFYAFGRVFSGVVSTGLKVRIMGPNYTPGKKEDLYLKPIQRT 450

  Fly   534 WVFESRYKVELNRVPAGNWVLIEGIDQCIVKTSTIVDINVPEDLYIFRPLKFNTQSIIKIAVEPV 598
            .:...||...:..||.||.|.:.|:||.:|||.||...:...::   |.:||:...::::|||..
Zfish   451 ILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFDQAHNM---RVMKFSVSPVVRVAVEAK 512

  Fly   599 NPSELPKMLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV 663
            ||::|||:::||:::.||.|::...:||||||:|.|.|||:|:..:.||.:.::.|.:|.:||||
Zfish   513 NPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVV 577

  Fly   664 AFCETVVETSSLKCFAETPNKKNKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWD 728
            ::.|||...|...|.:::|||.|::.|.:.|...||||||:.|.|......|....:....|:|:
Zfish   578 SYRETVSAESDQMCLSKSPNKHNRLYMKARPFPDGLAEDIDKGDVSSRQELKTRARYLADKYEWE 642

  Fly   729 LLAARSIWAFGPDSTGPNILVDDTLPSEVDKNL--LTAVKDSIVQGFQWGTREGPLCEEPIRNVK 791
            :..||.||.||||.||||:|||      |.|.:  |..:|||:|.||||.|:||.||||.:|.|:
Zfish   643 VTEARKIWCFGPDGTGPNMLVD------VTKGVQYLNEIKDSVVAGFQWATKEGALCEENMRAVR 701

  Fly   792 FKILDGVIANEALHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARR 856
            |.|.|..:..:|:||||||||||||||.|:..|.|.||||||...||:|.|...|..:|.||.|:
Zfish   702 FDIHDVTLHTDAIHRGGGQIIPTARRVLYACQLTAEPRLMEPIYLVEIQCPEQVVGGIYGVLNRK 766

  Fly   857 RGHVTQDAPVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIII 921
            ||||.:::.|.|:|::.:||::|..:||||..|||::|.||||...||.||||:||||.|
Zfish   767 RGHVFEESQVMGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPKD----- 826

  Fly   922 RPLEPQQASHLAREFMIKTRRRKGLSEDV-SINKFFD 957
                   |:....:.:..||:||||.|.: :::.|.|
Zfish   827 -------AASKPCQIVADTRKRKGLKEGIPALDNFLD 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	334/880 (38%)
		Snu114p	132..340	CDD:206730	85/224 (38%)
		Translation_Factor_II_like	477..568	CDD:295476	34/90 (38%)
		snRNP_III	589..660	CDD:293921	29/70 (41%)
		EF2_IV_snRNP	660..837	CDD:238840	88/178 (49%)
		eEF2_C_snRNP	832..911	CDD:239765	39/78 (50%)
eef2b	NP_956752.2	PTZ00416	1..858	CDD:240409	335/882 (38%)
		EF2	20..233	CDD:206672	82/213 (38%)
		EF2_snRNP_like_II	394..488	CDD:293901	36/93 (39%)
		EF2_snRNP_III	503..574	CDD:293918	29/70 (41%)
		aeEF2_snRNP_like_IV	574..746	CDD:238839	88/177 (50%)
		eEF2_snRNP_like_C	742..821	CDD:239763	39/78 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820