DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4849 and Eef2

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_058941.1	Gene:	Eef2 / 29565	RGDID:	61979	Length:	858	Species:	Rattus norvegicus

Alignment Length:	877	Identity:	341/877 - (38%)
Similarity:	518/877 - (59%)	Gaps:	59/877 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 MEFMAD----LMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQE 178
            :.|..|    :||....|||::::.|:.|||:|..|.|:.:. ....:....:.|:|||...|||
  Rat     2 VNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKA-GIIASARAGETRFTDTRKDEQE 65

  Fly   179 RGCSIKATPVTLV-------LQDVKQ----KSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFID 232
            |..:||:|.::|.       |..:||    ..:|:|:.|:||||:||.|.|||:|::||.::.:|
  Rat    66 RCITIKSTAISLFYELSENDLNFIKQSKDGSGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVD 130

  Fly   233 AAEGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYG-- 295
            ...||.:.||.:|:.|:.||....:.:||:||.:|||:|.|::.|...:.|||.||.::||||
  Rat   131 CVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEG 195

  Fly   296 --APDDNLLVSPILGNVCFASSLYGFCFTLKSFAKLYADTY--EGVAYL----------DFAKRL 346
              .|..|:::.|:||.|.|.|.|:|:.||||.||::|...:  :|...|          |..|:|
  Rat   196 ESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLGAAERAKKVEDMMKKL 260

  Fly   347 WGDMYFNSKTRKFSKKQPHNSAQ-----RSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRV 406
            |||.||:....||||..  ||..     |:|.:.||:|::|:...::.......:..:.:|::::
  Rat   261 WGDRYFDPANGKFSKSA--NSPDGKKLPRTFCQLILDPIFKVFDAIMNFRKEETAKLIEKLDIKL 323

  Fly   407 SKEEMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMISC 471
            ..|:.....:|||:.|..|::......:.|...|:.||:...|.:.:.:|.||.:.:....:.||
  Rat   324 DSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSC 388

  Fly   472 NQYGTLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWVF 536
            :..|.||::.|||.|..|...|....|:.||.:..|.:||::|.|||...:||..:..:.|..:.
  Rat   389 DPKGPLMMYISKMVPTSDKGRFYAFGRVFSGVVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILM 453

  Fly   537 ESRYKVELNRVPAGNWVLIEGIDQCIVKTSTIVDINVPEDLYIFRPLKFNTQSIIKIAVEPVNPS 601
            ..||...:..||.||.|.:.|:||.:|||.||...   |..:..|.:||:...::::|||..||:
  Rat   454 MGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTF---EHAHNMRVMKFSVSPVVRVAVEAKNPA 515

  Fly   602 ELPKMLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFC 666
            :|||:::||:::.||.|::...:||||||:|.|.|||:|:..:.||.:.::.|.||.:||||::.
  Rat   516 DLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYR 580

  Fly   667 ETVVETSSLKCFAETPNKKNKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLLA 731
            |||.|.|::.|.:::|||.|::.|.:.|...||||||:.|.|......|....:....|:||:..
  Rat   581 ETVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKARARYLAEKYEWDVAE 645

  Fly   732 ARSIWAFGPDSTGPNILVDDTLPSEVDKNLLTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILD 796
            ||.||.||||.||||||.|.|...:    .|..:|||:|.||||.|:||.||||.:|.|:|.:.|
  Rat   646 ARKIWCFGPDGTGPNILTDITKGVQ----YLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHD 706

  Fly   797 GVIANEALHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVT 861
            ..:..:|:|||||||||||||..|::.|.|.||||||...||:|.|...|..:|.||.|:||||.
  Rat   707 VTLHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVF 771

  Fly   862 QDAPVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIIRPLEP 926
            :::.|:|:|::.:||::|..:||||..|||::|.||||...||.||||:||||.|.|  .||
  Rat   772 EESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNS--SRP--- 831

  Fly   927 QQASHLAREFMIKTRRRKGLSEDV-SINKFFD 957
                   .:.:.:||:||||.|.: :::.|.|
  Rat   832 -------SQVVAETRKRKGLKEGIPALDNFLD 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	340/875 (39%)
		Snu114p	132..340	CDD:206730	86/224 (38%)
		Translation_Factor_II_like	477..568	CDD:295476	34/90 (38%)
		snRNP_III	589..660	CDD:293921	30/70 (43%)
		EF2_IV_snRNP	660..837	CDD:238840	87/176 (49%)
		eEF2_C_snRNP	832..911	CDD:239765	39/78 (50%)
Eef2	NP_058941.1	PTZ00416	1..858	CDD:240409	341/877 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720