DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4849 and cwf10

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_596689.2	Gene:	cwf10 / 2540711	PomBaseID:	SPBC215.12	Length:	984	Species:	Schizosaccharomyces pombe

Alignment Length:	995	Identity:	529/995 - (53%)
Similarity:	695/995 - (69%)	Gaps:	36/995 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSDLYDEFGNYIGPDLDSDEEDEQSIYGQ---PDVQDDP--EDAMDEDEVEPQEDEDKEV---- 56
            |:.||||||||||||:   :||||:.::.|   |.:...|  |:.:.::|:|..|..::..
pombe     2 MEEDLYDEFGNYIGPE---NEEDEEELFPQAPSPTIAQVPSFEEVIPDEELEDVERAEEMALSHL 63

  Fly    57 ---TAVVLHEDKRYYPSAVEVYGPDVETIVQEEDAQPLDKPLIEPVKKLKFQIKEQDMQETTYDM 118
               .||||||||:|||||.||||.:|:.:|||:|.|||.:|:|||::..:..|:..::.:|.|..
pombe    64 EPQNAVVLHEDKQYYPSAEEVYGSNVDIMVQEQDTQPLSQPIIEPIRHKRIAIETTNVPDTVYKK 128

  Fly   119 EFMADLMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQERGCSI 183
            ||:..|:.....:|:..:.|||||||:..:|.|:..|||..:..:.|.||||||.:.|:||..||
pombe   129 EFLFGLLTGTDDVRSFIVAGHLHHGKSALLDLLVYYTHPDTKPPKRRSLRYTDTHYLERERVMSI 193

  Fly   184 KATPVTLVLQDVKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHA 248
            |:||:||.:.|:|.|::.....||||||:|.||..|.|.:||||||.:|..||||:||.|::|||
pombe   194 KSTPLTLAVSDMKGKTFAFQCIDTPGHVDFVDEVAAPMAISDGVVLVVDVIEGVMINTTRIIKHA 258

  Fly   249 VQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYGAPDDNLL---------VS 304
            :.....|.:.:||:|||||||:|||.|||.||:|:::|||          ||:.         ||
pombe   259 ILHDMPIVLVLNKVDRLILELRLPPNDAYHKLRHVIDEVN----------DNICQISKDLKYRVS 313

  Fly   305 PILGNVCFASSLYGFCFTLKSFAKLYADTYEGVAYLDFAKRLWGDMYFNSKTRKFSKKQPHNSAQ 369
            |.||||||||...|:||||.||||||.|.:.|:....|:||||||:||:||||||:|:....|..
pombe   314 PELGNVCFASCDLGYCFTLSSFAKLYIDRHGGIDVDLFSKRLWGDIYFDSKTRKFAKQSLDGSGV 378

  Fly   370 RSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRVSKEEMKSNIRPLLRLVCNRFMGDCSGFV 434
            ||||.|||||:|||....:.|....|...|:...:.:..::...:.:|||:|:|..|.|...|||
pombe   379 RSFVHFILEPLYKLHTLTISDEAEKLKKHLSSFQIYLKPKDYLLDPKPLLQLICASFFGFPVGFV 443

  Fly   435 DMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMI--SCNQYGTLMVHSSKMYPNDDCTFFQVLA 497
            :....||.||.|||.||....|.||....|.:.::  |..:...|::|.:|:|...|...|...|
pombe   444 NAVTRHIPSPRENAARKASQSYIGPINSSIGKAILEMSREESAPLVMHVTKLYNTVDANNFYAFA 508

  Fly   498 RIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWVFESRYKVELNRVPAGNWVLIEGIDQCI 562
            |:.||.:..||:|:||||||:|:||||..:..:..:.|..:||::.::...||..||:.|:|..|
pombe   509 RVYSGQVKKGQKVKVLGENYSLEDEEDMVVAHIAEICVPCARYRLHVDGAVAGMLVLLGGVDNSI 573

  Fly   563 VKTSTIVDINVPEDLYIFRPLKFNTQSIIKIAVEPVNPSELPKMLDGLRKVNKSYPLLSTRVEES 627
            .||:|||..|:.:|.|||||:...::|:.|:||||.|||||||:||||||.||||||..|:||||
pombe   574 SKTATIVSDNLKDDPYIFRPIAHMSESVFKVAVEPHNPSELPKLLDGLRKTNKSYPLSITKVEES 638

  Fly   628 GEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFCETVVETSSLKCFAETPNKKNKITMIS 692
            |||.|.||||:|:||:::|||.:||||:|:|:|||..||||.|:|||:|||::||||||:|||:.
pombe   639 GEHTIFGTGEMYMDCLLYDLRTLYSEIEIRVSDPVARFCETAVDTSSIKCFSDTPNKKNRITMVV 703

  Fly   693 EPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLLAARSIWAFGPDSTGPNILVDDTLPSEV 757
            ||||||::.|||||.|.|||.:|||.||||.||||||||:|||||||||..|.|||.||||.::|
pombe   704 EPLEKGISNDIENGKVNINWPQKRISEFFQKNYDWDLLASRSIWAFGPDDRGTNILRDDTLSTDV 768

  Fly   758 DKNLLTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILDGVIANEALHRGGGQIIPTARRVAYSA 822
            |||:|.:||:.|.|||||||||||||:|.||||.|:::|.|:|.|.::|||||||||||||.||:
pombe   769 DKNVLNSVKEYIKQGFQWGTREGPLCDETIRNVNFRLMDVVLAPEQIYRGGGQIIPTARRVCYSS 833

  Fly   823 FLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQDAPVSGSPIYTIKAFIPAIDSFGFE 887
            ||.|:||||||...|||.||||.:..:|.:|.||||||.||.|..|||:|.::|.||.|||.|||
pombe   834 FLTASPRLMEPVYMVEVHAPADSLPIIYDLLTRRRGHVLQDIPRPGSPLYLVRALIPVIDSCGFE 898

  Fly   888 TDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIIRPLEPQQASHLAREFMIKTRRRKGLSEDVSI 952
            ||||.||||||.|..||.|||:||||||||||..:||||.:.|.|||:|:|||||||||.||||.
pombe   899 TDLRVHTQGQAMCQMVFDHWQVVPGDPLDKSIKPKPLEPARGSDLARDFLIKTRRRKGLVEDVST 963

  Fly   953 NKFFDDPMLLELARQDVLIN 972
            .::||..|:..|....|:::
pombe   964 TRYFDQEMIDSLKEAGVVLS 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623	53/118 (45%)
		PTZ00416	115..957	CDD:240409	469/852 (55%)
		Snu114p	132..340	CDD:206730	109/216 (50%)
		Translation_Factor_II_like	477..568	CDD:295476	36/90 (40%)
		snRNP_III	589..660	CDD:293921	50/70 (71%)
		EF2_IV_snRNP	660..837	CDD:238840	125/176 (71%)
		eEF2_C_snRNP	832..911	CDD:239765	49/78 (63%)
cwf10	NP_596689.2	EFTUD2	5..122	CDD:292623	53/119 (45%)
		PTZ00416	139..967	CDD:240409	465/837 (56%)
		Snu114p	142..339	CDD:206730	105/206 (51%)
		EF2_II_snRNP	488..581	CDD:293907	38/92 (41%)
		snRNP_III	600..671	CDD:293921	50/70 (71%)
		EF2_IV_snRNP	671..848	CDD:238840	125/176 (71%)
		eEF2_C_snRNP	843..922	CDD:239765	49/78 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	206	1.000	Domainoid score	I625
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3133
Inparanoid	1	1.050	1043	1.000	Inparanoid score	I30
OMA	1	1.010	-	-		QHG54470
OrthoFinder	1	1.000	-	-		FOG0004923
OrthoInspector	1	1.000	-	-		oto101721
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	1	1.100	-	-	LDO	PTHR42908
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3947
SonicParanoid	1	1.000	-	-		X2958
TreeFam	1	0.960	-	-
	14	13.860