DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4849 and EEF2

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001952.1	Gene:	EEF2 / 1938	HGNCID:	3214	Length:	858	Species:	Homo sapiens

Alignment Length:	875	Identity:	339/875 - (38%)
Similarity:	518/875 - (59%)	Gaps:	55/875 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 MEFMAD----LMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQE 178
            :.|..|    :||....|||::::.|:.|||:|..|.|:.:. ....:....:.|:|||...|||
Human     2 VNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKA-GIIASARAGETRFTDTRKDEQE 65

  Fly   179 RGCSIKATPVTLV-------LQDVKQK----SYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFID 232
            |..:||:|.::|.       |..:||.    .:|:|:.|:||||:||.|.|||:|::||.::.:|
Human    66 RCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVD 130

  Fly   233 AAEGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYG-- 295
            ...||.:.||.:|:.|:.||....:.:||:||.:|||:|.|::.|...:.|||.||.::||||
Human   131 CVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEG 195

  Fly   296 --APDDNLLVSPILGNVCFASSLYGFCFTLKSFAKLYADTY--EGVAYL----------DFAKRL 346
              .|..|:::.|:||.|.|.|.|:|:.||||.||::|...:  :|...|          |..|:|
Human   196 ESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLGPAERAKKVEDMMKKL 260

  Fly   347 WGDMYFNSKTRKFSKKQPHNSAQ---RSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRVSK 408
            |||.||:....||||.......:   |:|.:.||:|::|:...::.......:..:.:|::::..
Human   261 WGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVFDAIMNFKKEETAKLIEKLDIKLDS 325

  Fly   409 EEMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMISCNQ 473
            |:.....:|||:.|..|::......:.|...|:.||:...|.:.:.:|.||.:.:....:.||:.
Human   326 EDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDP 390

  Fly   474 YGTLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWVFES 538
            .|.||::.|||.|..|...|....|:.||.:..|.:||::|.|||...:||..:..:.|..:...
Human   391 KGPLMMYISKMVPTSDKGRFYAFGRVFSGLVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMG 455

  Fly   539 RYKVELNRVPAGNWVLIEGIDQCIVKTSTIVDINVPEDLYIFRPLKFNTQSIIKIAVEPVNPSEL 603
            ||...:..||.||.|.:.|:||.:|||.||...   |..:..|.:||:...::::|||..||::|
Human   456 RYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTF---EHAHNMRVMKFSVSPVVRVAVEAKNPADL 517

  Fly   604 PKMLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFCET 668
            ||:::||:::.||.|::...:||||||:|.|.|||:|:..:.||.:.::.|.||.:||||::.||
Human   518 PKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRET 582

  Fly   669 VVETSSLKCFAETPNKKNKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLLAAR 733
            |.|.|::.|.:::|||.|::.|.:.|...||||||:.|.|......|:...:....|:||:..||
Human   583 VSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEAR 647

  Fly   734 SIWAFGPDSTGPNILVDDTLPSEVDKNLLTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILDGV 798
            .||.||||.||||||.|.|...:    .|..:|||:|.||||.|:||.||||.:|.|:|.:.|..
Human   648 KIWCFGPDGTGPNILTDITKGVQ----YLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVT 708

  Fly   799 IANEALHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQD 863
            :..:|:|||||||||||||..|::.|.|.||||||...||:|.|...|..:|.||.|:||||.::
Human   709 LHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEE 773

  Fly   864 APVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIIRPLEPQQ 928
            :.|:|:|::.:||::|..:||||..|||::|.||||...||.||||:||||.|.|  .||
Human   774 SQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNS--SRP----- 831

  Fly   929 ASHLAREFMIKTRRRKGLSEDV-SINKFFD 957
                 .:.:.:||:||||.|.: :::.|.|
Human   832 -----SQVVAETRKRKGLKEGIPALDNFLD 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	338/873 (39%)
		Snu114p	132..340	CDD:206730	86/224 (38%)
		Translation_Factor_II_like	477..568	CDD:295476	34/90 (38%)
		snRNP_III	589..660	CDD:293921	30/70 (43%)
		EF2_IV_snRNP	660..837	CDD:238840	87/176 (49%)
		eEF2_C_snRNP	832..911	CDD:239765	39/78 (50%)
EEF2	NP_001952.1	PTZ00416	1..858	CDD:240409	339/875 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720