DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4849 and eftu-2

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_498308.1	Gene:	eftu-2 / 175851	WormBaseID:	WBGene00001166	Length:	974	Species:	Caenorhabditis elegans

Alignment Length:	977	Identity:	658/977 - (67%)
Similarity:	802/977 - (82%)	Gaps:	19/977 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSDLYDEFGNYIGPDLDSDEEDEQSIYGQPDVQDDPEDAMDEDE-VEP---QEDEDKEV--TAV 59
            |||||||||||||||:||||::     .|..|...|.||..|.|| .||   :||:.:|:  ..|
Worm     1 MDSDLYDEFGNYIGPELDSDDD-----AGDIDDNGDDEDRSDVDEDDEPDRMEEDDAEEIPQNQV 60

  Fly    60 VLHEDKRYYPSAVEVYGPDVETIVQEEDAQPLDKPLIEPVKKLKFQIKEQDMQETTYDMEFMADL 124
            ||||||:||.:|:||||..|||:|||||||||.:|:::||.|.|||..|:.:.||.|..|::|||
Worm    61 VLHEDKKYYATALEVYGEGVETLVQEEDAQPLTEPIVKPVSKKKFQAAERFLPETVYKKEYLADL 125

  Fly   125 MDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQERGCSIKATPVT 189
            ||.|.::||||:.||||||||||:|||:.||||:|...|:...|:||.||.|::||||||:.||:
Worm   126 MDCPHIMRNVAIAGHLHHGKTTFLDCLMEQTHPEFYRAEDADARFTDILFIEKQRGCSIKSQPVS 190

  Fly   190 LVLQDVKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQA 254
            :|.||.:.|||||||.|||||||||||.||:.|::||||:.:||.||||:||||.::||:|||.|
Worm   191 IVAQDSRSKSYLLNIIDTPGHVNFSDEMTASYRLADGVVVMVDAHEGVMMNTERAIRHAIQERLA 255

  Fly   255 ITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYGAPDDNLLVSPILGNVCFASSLYGF 319
            :|:||:|||||:|||||||.||||||:.|:::||.:|||: |.:|..::||:.|||.|:|..|..
Worm   256 VTLCISKIDRLLLELKLPPADAYFKLRLIIDQVNNILSTF-AEEDVPVLSPLNGNVIFSSGRYNV 319

  Fly   320 CFTLKSFAKLYA----DTYEGVAYLDFAKRLWGDMYFNSKTRKFSKKQPHNSAQRSFVEFILEPM 380
            ||:|.||:.:||    |::..   .:||:|||||:||..|||||.||.|.:.|.|:||:||||||
Worm   320 CFSLLSFSNIYAKQHGDSFNS---KEFARRLWGDIYFEKKTRKFVKKSPSHDAPRTFVQFILEPM 381

  Fly   381 YKLIAQVVGDVDTTLSDTLAELNVRVSKEEMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPL 445
            ||:.:||||||||.|.|.:|||.:|:||||.|.|:|||:.|:|.||.||.|.|||:.|::|||||
Worm   382 YKIFSQVVGDVDTCLPDVMAELGIRLSKEEQKMNVRPLIALICKRFFGDFSAFVDLVVQNIKSPL 446

  Fly   446 ENAKRKVDHIYTGPKEGDIYRDMISCNQYGTLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEV 510
            ||||.|::..|.||.:..:.::|..||..|.||||::|.||.||.|.|.|..|::||||.|..:|
Worm   447 ENAKTKIEQTYLGPADSQLAQEMQKCNAEGPLMVHTTKNYPVDDATQFHVFGRVMSGTLEANTDV 511

  Fly   511 RVLGENYTLQDEEDSRILQVGRLWVFESRYKVELNRVPAGNWVLIEGIDQCIVKTSTIVDINVPE 575
            |||||||::|||||.|.:.||||:|..:.|::|::|||||.|||||||||.||||:||.::...|
Worm   512 RVLGENYSIQDEEDCRRMTVGRLFVRVASYQIEVSRVPAGCWVLIEGIDQPIVKTATIAELGYEE 576

  Fly   576 DLYIFRPLKFNTQSIIKIAVEPVNPSELPKMLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYL 640
            |:||||||||||:|.:|:||||:||||||||||||||||||||||:||||||||||:|||||.|:
Worm   577 DVYIFRPLKFNTRSCVKLAVEPINPSELPKMLDGLRKVNKSYPLLTTRVEESGEHVLLGTGEFYM 641

  Fly   641 DCVMHDLRKMYSEIDIKVADPVVAFCETVVETSSLKCFAETPNKKNKITMISEPLEKGLAEDIEN 705
            ||||||:||::||||||||||||.|.|||:|||:||||||||||||||||::|||||.|.|||||
Worm   642 DCVMHDMRKVFSEIDIKVADPVVTFNETVIETSTLKCFAETPNKKNKITMMAEPLEKQLDEDIEN 706

  Fly   706 GTVCINWNKKRIGEFFQVNYDWDLLAARSIWAFGPDSTGPNILVDDTLPSEVDKNLLTAVKDSIV 770
            ..|.|.||::|:|||||..|:|||||||||||||||:||||||:||||||||||:||:.|::|:|
Worm   707 EVVQIGWNRRRLGEFFQTKYNWDLLAARSIWAFGPDTTGPNILLDDTLPSEVDKHLLSTVRESLV 771

  Fly   771 QGFQWGTREGPLCEEPIRNVKFKILDGVIANEALHRGGGQIIPTARRVAYSAFLMATPRLMEPYL 835
            |||||.||||||||||||.||||:||..||.|.|:|||||:||||||.||||||||||||||||.
Worm   772 QGFQWATREGPLCEEPIRQVKFKLLDAAIATEPLYRGGGQMIPTARRCAYSAFLMATPRLMEPYY 836

  Fly   836 FVEVQAPADCVSAVYTVLARRRGHVTQDAPVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQAFC 900
            .|||.||||||:|||||||:||||||.|||:.|||:|||.|:||.:||||||||||.||||||||
Worm   837 TVEVVAPADCVAAVYTVLAKRRGHVTTDAPMPGSPMYTISAYIPVMDSFGFETDLRIHTQGQAFC 901

  Fly   901 LSVFHHWQIVPGDPLDKSIIIRPLEPQQASHLAREFMIKTRRRKGLSEDVSINKFFDDPMLLELA 965
            :|.|||||:||||||||||:|:.|:.|...|||||||||||||||||||||:|||||||||||||
Worm   902 MSAFHHWQLVPGDPLDKSIVIKTLDVQPTPHLAREFMIKTRRRKGLSEDVSVNKFFDDPMLLELA 966

  Fly   966 RQ 967
            :|
Worm   967 KQ 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623	63/112 (56%)
		PTZ00416	115..957	CDD:240409	579/845 (69%)
		Snu114p	132..340	CDD:206730	126/211 (60%)
		Translation_Factor_II_like	477..568	CDD:295476	57/90 (63%)
		snRNP_III	589..660	CDD:293921	59/70 (84%)
		EF2_IV_snRNP	660..837	CDD:238840	139/176 (79%)
		eEF2_C_snRNP	832..911	CDD:239765	61/78 (78%)
eftu-2	NP_498308.1	EFTUD2	4..113	CDD:374287	63/113 (56%)
eftu-2	NP_498308.1	FusA	125..958	CDD:357662	575/836 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161244
Domainoid	1	1.000	260	1.000	Domainoid score	I1064
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3133
Inparanoid	1	1.050	1348	1.000	Inparanoid score	I64
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54470
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	1	1.000	-	-		FOG0004923
OrthoInspector	1	1.000	-	-		oto18055
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	1	1.100	-	-	LDO	PTHR42908
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3947
SonicParanoid	1	1.000	-	-		X2958
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800