DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4849 and eef-2

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001369996.1	Gene:	eef-2 / 172743	WormBaseID:	WBGene00001167	Length:	852	Species:	Caenorhabditis elegans

Alignment Length:	875	Identity:	323/875 - (36%)
Similarity:	517/875 - (59%)	Gaps:	61/875 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 MEFMAD----LMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQE 178
            :.|..|    |||....|||::::.|:.|||:|..|.|:.:. ......:..:.|:|||...|||
Worm     2 VNFTVDEIRALMDRKRNIRNMSVIAHVDHGKSTLTDSLVSKA-GIIAGSKAGETRFTDTRKDEQE 65

  Fly   179 RGCSIKATPVTLVLQ--------------------DVKQKSY---LLNIFDTPGHVNFSDEATAA 220
            |..:||:|.::|..:                    |.|::.|   |:|:.|:||||:||.|.|||
Worm    66 RCITIKSTAISLFFELEKKDLEFVKGENQFETVEVDGKKEKYNGFLINLIDSPGHVDFSSEVTAA 130

  Fly   221 MRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVE 285
            :|::||.::.:|...||.:.||.:|:.|:.||....:.:||:||.:|||:|..::.:...:.|||
Worm   131 LRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLFMNKMDRALLELQLGAEELFQTFQRIVE 195

  Fly   286 EVNGLLSTYGAPDDN-----LLVSPILGNVCFASSLYGFCFTLKSFAKLYADTYEGVAYLDFAKR 345
            .:|.:::|||  ||:     ::|.|.:|||.|.|.|:|:.||||.||::||..: ||......|.
Worm   196 NINVIIATYG--DDDGPMGPIMVDPSIGNVGFGSGLHGWAFTLKQFAEMYAGKF-GVQVDKLMKN 257

  Fly   346 LWGDMYFNSKTRKFSKKQPHNSAQRSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRVSKEE 410
            ||||.:|:.||:|:|..|...| :|.|.:|:|:|::.:...|:.......:..:.:|.::::.:|
Worm   258 LWGDRFFDLKTKKWSSTQTDES-KRGFCQFVLDPIFMVFDAVMNIKKDKTAALVEKLGIKLANDE 321

  Fly   411 MKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMISCNQYG 475
            .....:||:::...:::......:.|...|:.||:...|.:::.:|.||.:.:....:.:|:..|
Worm   322 KDLEGKPLMKVFMRKWLPAGDTMLQMIAFHLPSPVTAQKYRMEMLYEGPHDDEAAVAIKTCDPNG 386

  Fly   476 TLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWVFESRY 540
            .||::.|||.|..|...|....|:.||.:..|.:.|:.|.||....:||.....:.|..:...|:
Worm   387 PLMMYISKMVPTSDKGRFYAFGRVFSGKVATGMKARIQGPNYVPGKKEDLYEKTIQRTILMMGRF 451

  Fly   541 KVELNRVPAGNWVLIEGIDQCIVKTSTIVDINVPEDLYIFRPLKFNTQSIIKIAVEPVNPSELPK 605
            ...:..:|:||...:.|:||.:||..||...   :|.:..|.:||:...::::|||..||::|||
Worm   452 IEPIEDIPSGNIAGLVGVDQYLVKGGTITTY---KDAHNMRVMKFSVSPVVRVAVEAKNPADLPK 513

  Fly   606 MLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFCETVV 670
            :::||:::.||.|::....||||||:|.|.|||:|:..:.||.:.::.|.:|.:||||::.|||.
Worm   514 LVEGLKRLAKSDPMVQCIFEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVQ 578

  Fly   671 ETSSLKCFAETPNKKNKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLLAARSI 735
            ..|:..|.:::|||.|::...::|:..|||:|||.|||......|...:.....|::|:..||.|
Worm   579 SESNQICLSKSPNKHNRLHCTAQPMPDGLADDIEGGTVNARDEFKARAKILAEKYEYDVTEARKI 643

  Fly   736 WAFGPDSTGPNILVDDTLPSEVDKNL--LTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILDGV 798
            |.||||.||||:|:|      |.|.:  |..:|||:|.||||.||||.|.:|.:|.|:|.:.|..
Worm   644 WCFGPDGTGPNLLMD------VTKGVQYLNEIKDSVVAGFQWATREGVLSDENMRGVRFNVHDVT 702

  Fly   799 IANEALHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQD 863
            :..:|:||||||||||||||.|::.|.|.|||:||...||:|.|...|..:|.||.||||||.::
Worm   703 LHADAIHRGGGQIIPTARRVFYASVLTAEPRLLEPVYLVEIQCPEAAVGGIYGVLNRRRGHVFEE 767

  Fly   864 APVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIIRPLEPQQ 928
            :.|:|:|::.:||::|..:||||..|||::|.||||...||.|||::|||||:..     .:|.|
Worm   768 SQVTGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPLEAG-----TKPNQ 827

  Fly   929 ASHLAREFMIKTRRRKGLSEDV-SINKFFD 957
                   .::.||:||||.|.| :::.:.|
Worm   828 -------IVLDTRKRKGLKEGVPALDNYLD 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	322/873 (37%)
		Snu114p	132..340	CDD:206730	85/235 (36%)
		Translation_Factor_II_like	477..568	CDD:295476	28/90 (31%)
		snRNP_III	589..660	CDD:293921	29/70 (41%)
		EF2_IV_snRNP	660..837	CDD:238840	84/178 (47%)
		eEF2_C_snRNP	832..911	CDD:239765	39/78 (50%)
eef-2	NP_001369996.1	PTZ00416	1..852	CDD:240409	323/875 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820