DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4849 and Gfm1

DIOPT Version :9

Sequence 1:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_446077.2	Gene:	Gfm1 / 114017	RGDID:	631396	Length:	751	Species:	Rattus norvegicus

Alignment Length:	877	Identity:	190/877 - (21%)
Similarity:	319/877 - (36%)	Gaps:	230/877 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 IRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLR-----YTDTLFTEQERGCSIKATPVTL 190
            |||:.:..|:..||||..:.::..| .:..||.|.:.:     ..|::..|::||.:|::.....
  Rat    47 IRNIGISAHIDSGKTTLTERVLYYT-GRIATMHEVKGKDGVGAVMDSMELERQRGITIQSAATYT 110

  Fly   191 VLQDVKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQAI 255
            :.:||.     :||.||||||:|:.|...|:|:.||.||.:.|..||...|..:.:...:.....
  Rat   111 MWRDVN-----INIIDTPGHVDFTIEVERALRVLDGAVLVLCAVGGVQCQTMTVSRQMKRYNVPF 170

  Fly   256 TVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYGAPDDNLLVSPILGNVCFASSLYGFC 320
            ...|||:||:........|....||.|                          |..|.....|
  Rat   171 LTFINKLDRMGSNPARALQQMRSKLNH--------------------------NAAFVQIPIG-- 207

  Fly   321 FTLKSFAKLYADTYEGVAYLDFAKRLWGDMYFNSKTRKFSKKQPHNSAQRSFVEFILEPMYKLIA 385
                    |..| ::|:..|...:.::.|..|....|.........:|.....:.::|
  Rat   208 --------LEGD-FKGIIDLIEERAIYFDGDFGQIVRYDEIPADLRAAAADHRQELIE------- 256

  Fly   386 QVVGDVDTTLSDTLAELNVRVSKEEMKSNIR--PLLRLVCNRFMGDC------SGFVDMCVEHIK 442
             .|.:.|..|.:...|..: .|..::|..||  .|.|.....|:|..      ...:|..:|.:.
  Rat   257 -CVANSDEQLGELFLEEKI-PSVSDLKLAIRRATLSRSFTPVFLGSALKNKGVQPLLDAVLEFLP 319

  Fly   443 SPLE---------NAKRKVDHIYTGPKEGDIYRDM-----ISCNQYGTLMVHSSKMYPNDDCTFF 493
            :|.|         |..::.:.|...||..|.:..:     :...::|.|
  Rat   320 NPSEVQNYALLNQNDSKEKNKILMNPKRDDSHPFVGLAFKLEAGRFGQL---------------- 368

  Fly   494 QVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWVFESRYKVELNRVPAGNWVLIEGI 558
             ...|...|.|..|.         |:.:....:.::|.||....:....::..|.||:...:.||
  Rat   369 -TYVRNYQGELKKGS---------TIYNTRTGKKVRVQRLVRMHADMMEDVEEVYAGDICALFGI 423

  Fly   559 DQCIVKTSTIVD--------INVPEDLYIFRPLKFNTQSIIKIAVEPVNPSELPKMLDGLRKVNK 615
            |.....|.|..|        |:||:             .:|.:|::|.|.::|.|...|:.:..:
  Rat   424 DCASGDTFTNKDNSDLSMESIHVPD-------------PVISVAMKPSNKNDLEKFSKGIARFTR 475

  Fly   616 SYPLLSTRVE-ESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFCETVVETSSLKCFA 679
            ..|......: ||.|.::.|.|||:|:.....:.:.|. .......|.|||.|||.        |
  Rat   476 EDPTFKVHFDTESKETIVSGMGELHLEIYAQRMEREYG-CPCITGKPKVAFRETVT--------A 531

  Fly   680 ETP----NKK--------NKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLLAA 732
            ..|    :||        .|:..:.|||
  Rat   532 PVPFDFTHKKQSGGAGQYGKVIGVLEPL------------------------------------- 559

  Fly   733 RSIWAFGPDSTGPNILVDDTLPSEVDKNLLTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILDG 797
                  .|:........|:|..:.|.|..:.||:    :||.....:|||....:..::|.:.||
  Rat   560 ------APEDYTKLEFSDETFGANVPKQFVPAVE----KGFLDACEKGPLSGHKLSGLRFVLQDG 614

  Fly   798 ----VIANEA--LHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARR 856
                |.:||.  :..|.|.:        ..|...||..::||.:.|||.||.:...||:..:.||
  Rat   615 AHHMVDSNEISFIRAGEGAL--------KQALASATLCIIEPIMSVEVIAPNEFQGAVFAGINRR 671

  Fly   857 RGHVT-QDAPVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSII 920
            .|.:| ||..   ...:|:.|.:|..:.||:.|:||:.|:|:......::.:|
  Rat   672 HGVITGQDGI---EDYFTLYADVPLNNMFGYSTELRSCTEGKGEYTMEYNRYQ------------ 721

  Fly   921 IRPLEPQQASHLAREFMIKTRR---RKGLSED 949
              |..|.....|..:::..|.:   :||.:::
  Rat   722 --PCSPSTQEELVNKYLEATGQLPVKKGKAKN 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	190/877 (22%)
		Snu114p	132..340	CDD:206730	53/212 (25%)
		Translation_Factor_II_like	477..568	CDD:295476	16/90 (18%)
		snRNP_III	589..660	CDD:293921	17/71 (24%)
		EF2_IV_snRNP	660..837	CDD:238840	40/194 (21%)
		eEF2_C_snRNP	832..911	CDD:239765	26/79 (33%)
Gfm1	NP_446077.2	PRK12740	53..732	CDD:237186	183/850 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810