Protein Alignment CG4849 and Efl1

DIOPT Version :9

• Sequence 1: NP_651605.1
• Gene: CG4849 / 43358
• FlyBaseID: FBgn0039566
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_001153144.1
• Gene: Efl1 / 101592
• MGIID: 2141969
• Length: 1127
• Species: Mus musculus
• Alignment Length: 1102
• Identity: 271/1102 - (24%)
• Similarity: 456/1102 - (41%)
• Gaps: 299/1102 - (27%)

  Fly   131 IRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLRYTDTLFTEQERGCSIKATPVTLVLQDV 195
            |||:.::.|:.|||||..|||| .::....:....:|||.|:...||.||.::|::.::|...:
Mouse    19 IRNICVLAHVDHGKTTLADCLI-SSNGIISSRLAGKLRYMDSREDEQVRGITMKSSAISLHYAE- 81

  Fly   196 KQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQAITVCIN 260
            ..:.||:|:.|:||||:||.|.:.|:|:.||.::.:||.|||...|:.:|:.|..|.....:.||
Mouse    82 GHEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVIN 146

  Fly   261 KIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTY------------------------------- 294
            ||||||:|||..||:||..||:|:|::|.|..|.
Mouse   147 KIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAERETESQAKPHSEQGEQVYDW 211

  Fly   295 -----GAPDDNLLVSPILGNVCFASSLYGFCFTLKSFAKLYADTYEGVAYLDFAKRLWGDMYFNS 354
                 ...|..|..||..|||.|.|::.|:.|.::.||::|:... |:......|.||||.|.|.
Mouse   212 SAGLEDVDDSQLYFSPEQGNVVFTSAIDGWGFGIEHFARIYSQKI-GIKKEVLLKTLWGDYYINM 275

  Fly   355 KTRKFSKKQPHNSAQRSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRV-SKEEMKSNIRPL 418
            |.:|..|.......:..||:.|||.::.|...|:......:...:..|.::: ::|...|:.:..
Mouse   276 KAKKIMKVDQAKGKKPLFVQLILENIWSLYDAVLKKDKEKIDKIVTSLGLKIGAREARHSDPKVQ 340

  Fly   419 LRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIY-TG--------PKEGDIYRDMISCNQY 474
            :..:|::::......:.|....:.|||:....:|:.:. ||        |:...:....:.|...
Mouse   341 INAICSQWLPISHAVLAMVCHKLPSPLDMTSERVEKLLCTGSQTFESLPPETQALKAAFMKCGSE 405

  Fly   475 GT--LMVHSSKMY---------------------------------------------------- 485
            .|  :::..|||:
Mouse   406 DTAPVIIFVSKMFAVDVKALPQNKPRPLTQEEMAQRRERARQRHAEKLAAAQGQTSQGPTQDGGA 470

  Fly   486 ----PNDD-----------------------CTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEE 523
                |::|                       ...|...||:.||....|:::.|||..|:..|
Mouse   471 LETSPHEDEPRGDEPDVASVSRQPVSQEESSQEAFIAFARVFSGIARRGKKIFVLGPKYSPVD-- 533

  Fly   524 DSRILQ-----------------------VGRLWVFESRYKVELNRVPAGNWVLIEGIDQCIVKT 565
               .||                       :..|::...|...:|..||.||.:.|.|:...::|:
Mouse   534 ---FLQRVPLGFSAPLEDLPPVPHMACCTLENLYLLMGRELEDLEEVPPGNVLGIGGLQDFVLKS 595

  Fly   566 STIVDI-NVPEDLYIFRPLKFNTQSIIKIAVEPVNPSELPKMLDGLRKVNKSYPLLSTRVEESGE 629
            :|:..: :.|.    |.||.|....|:::||||.:|||:|:::.|::.:|::.|.:...::|:||
Mouse   596 ATLCSLPSCPP----FIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQVLIQETGE 656

  Fly   630 HVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFCETVVETSSLKCFAETPNKKNKITMISEP 694
            ||::..||::|...:.|||:.:::|.|.|::|::.|.||:.:...:....|...::.|:.:|.:.
Mouse   657 HVLVTAGEVHLQRCLDDLRERFAKIHISVSEPIIPFRETITKPPKVDMVNEEIGRQQKVAVIHQT 721

  Fly   695 LE------KGLAEDIENGTVCINWNKK-------------RIGEFFQVNYD-------------- 726
            .|      :|:..| .:|.:.|....|             .:....:.|.|
Mouse   722 KEEQSKIPEGIHVD-SDGLITIPTPNKLATLSVRAIPLPEEVTRILEENSDLIRSMELLTSSLNE 785

  Fly   727 ---------------WDL-------LAAR-------SIWAFGPDSTGPNILVDDTL--------- 753
                           |:.       |..|       .||:|||...||||||..:.
Mouse   786 GRNTQAIHQKTQEKIWEFKGKLEKHLTGRKWRNTVDQIWSFGPRKCGPNILVSRSEDFQNSVWSG 850

  Fly   754 PSEVDKNLLTAVKD---SIVQGFQWGTREGPLCEEPIRNVKFKILDGVI-------ANEALHRG- 807
            |:..:....:..:|   |||.|||..|..||:||||:..|.|.:....:       |::..|:|
Mouse   851 PAGRESKEASRFRDFGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWELNKCAEQGASDKQHQGQ 915

  Fly   808 -------------------------------------------------GGQIIPTARRVAYSAF 823
                                                             .||:|.|.:.....|.
Mouse   916 CDLAGEGQGGGKTCHVGDENQEQQDVCSEPFEETSQKGDSPVIDCYGPFSGQLIATMKEACRYAL 980

  Fly   824 LMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQDAPVSGSPIYTIKAFIPAIDSFGFET 888
            .:...|||......::.|.:|.:..||.||::|.|.|.|:....|:.::.|||.:|..:||||..
Mouse   981 QVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFAD 1045

  Fly   889 DLRTHTQGQAFCLSVFHHWQIVPGDPL----DKSIIIRPLEPQQASHLAREFMIKTRRRKGL 946
            ::|..|.|.|....||.||:::|.||.    .:...:...|...:.:.||::|...|:||||
Mouse  1046 EIRKRTSGLASPQLVFSHWEVIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGL 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623
		PTZ00416	115..957	CDD:240409	271/1102 (25%)
		Snu114p	132..340	CDD:206730	83/243 (34%)
		Translation_Factor_II_like	477..568	CDD:295476	28/192 (15%)
		snRNP_III	589..660	CDD:293921	26/70 (37%)
		EF2_IV_snRNP	660..837	CDD:238840	57/307 (19%)
		eEF2_C_snRNP	832..911	CDD:239765	27/78 (35%)
Efl1	NP_001153144.1	PTZ00416	1..1110	CDD:240409	271/1102 (25%)
		EF2	20..253	CDD:206672	81/234 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..496		2/66 (3%)
		EF2_II	505..600	CDD:293913	24/99 (24%)
		EF2_snRNP_III	616..687	CDD:293918	26/70 (37%)
		aeEF2_snRNP_like_IV	687..993	CDD:238839	57/306 (19%)
		eEF2_snRNP_like_C	990..1068	CDD:239763	27/77 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810