DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and ECEL1

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_004817.2	Gene:	ECEL1 / 9427	HGNCID:	3147	Length:	775	Species:	Homo sapiens

Alignment Length:	788	Identity:	203/788 - (25%)
Similarity:	331/788 - (42%)	Gaps:	144/788 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LPLYTRLAVCIL--------ICVILNDCEA-RSIGDESHENAITDETADYLRSH---GAMMKSYM 62
            ||.:.|..||:|        :|.||....| :.:|..:.......|.....::.   ...:.:.:
Human    52 LPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPVAAGGGACPEGCPERKAFARAARFLAANL 116

  Fly    63 NFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILD--ISY-TLMDVTEQLLTRTKLAEALNVSA 124
            :.|:|||.|||.||||.|.          ||..|.|  ::| |:..:.||...|.:...|.....
Human   117 DASIDPCQDFYSFACGGWL----------RRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPGGG 171

  Fly   125 ELLVAQR----FYNSCL----AAELFPRPAADPAYLSVIRSLGGF--------PAV------DRD 167
            ....|||    |:.|||    ...|.|||     .|.||...||:        |.|      :|.
Human   172 PGGAAQRKVRAFFRSCLDMREIERLGPRP-----MLEVIEDCGGWDLGGAEERPGVAARWDLNRL 231

  Fly   168 AWNA----SSFSWFNMSAHL-----SNYGVRSLIHEEILPQHPFNPYFKLPELGFDHVVHTAHVA 223
            .:.|    |:.:.|:::..|     |.|.:|  |.::.|         .|||       .|.::|
Human   232 LYKAQGVYSAAALFSLTVSLDDRNSSRYVIR--IDQDGL---------TLPE-------RTLYLA 278

  Fly   224 NTSSRAYQLNEHRMRGYLKEYNLTKDEISAVI--EGVFAFWSEALSIEDKF------ESDRDKCD 280
                     .:......|..|.:..:.:.:::  :.|.....|.|.:|.:.      |.|..:.|
Human   279 ---------QDEDSEKILAAYRVFMERVLSLLGADAVEQKAQEILQVEQQLANITVSEHDDLRRD 334

  Fly   281 LLSEIEEVPRFGQWRSYY-EIAWNGI-------DFYNGSSGGEFCDFYYVELDKVCAKHTEAVA- 336
            :.|...:| ..||.:... .:.|..:       ||............|..::.::.......|.
Human   335 VSSMYNKV-TLGQLQKITPHLRWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPHRVLH 398

  Fly   337 NYLAMRFLYRMDDKLKEP---------------KQPEDQKVNCLMIVQMTLPNLFNRLYMAEHFT 386
            |||..|.:..:.:.|..|               .:|::....||.............|::.|||:
Human   399 NYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKPQELARVCLGQANRHFGMALGALFVHEHFS 463

  Fly   387 DEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKNEELSDTLIREINN 451
            ....:::..:|.:::....|.||.::|:||||||.|.:|...:..::| |.:..|....:.:...
Human   464 AASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVG-YPDFLLKPDAVDKEYE 527

  Fly   452 LTIVEGSYAQSLINLRVLGTYLHRYAGLHADELPKDTKPLTLLVGMQ-VNAFYYNLDNSVYVMAG 515
            ..:.|.:|.::::|      .:.....|...::.::....|.|:..| :||:|....|.:...||
Human   528 FEVHEKTYFKNILN------SIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYYLPNKNQMVFPAG 586

  Fly   516 VLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYV 580
            :|.|..|...:|.||.:|.||.:||||||||:|..|..:|.:|.:..||:..|.:.|..:|:|.|
Human   587 ILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAECIV 651

  Fly   581 DYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGL 645
            ..::.:.:  .||.:.|..|..|||||.|||:.|   |..:.|.::..|.:        ..:|.|
Human   652 RLYDNFTV--YNQRVNGKHTLGENIADMGGLKLA---YHAYQKWVREHGPE--------HPLPRL 703

  Fly   646 DLSPEQLFFVGFAQLWCADYEPEH-YWEELTGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHP 709
            ..:.:||||:.|||.||.....:. |.:.||..|..:.|||||:||..::|...:.||..|||:|
Human   704 KYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNP 768

  Fly   710 KAESCRMW 717
             |..|.:|
Human   769 -AHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	190/724 (26%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	188/716 (26%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	188/716 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850