DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and ece2b

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_017206531.1	Gene:	ece2b / 793465	ZFINID:	ZDB-GENE-131120-140	Length:	794	Species:	Danio rerio

Alignment Length:	750	Identity:	194/750 - (25%)
Similarity:	320/750 - (42%)	Gaps:	166/750 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 SVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRTKLAEALNVSAEL-LV 128
            |.|||.|||::|||.|.. |.|......|.:..:   ::.|..:.:|.........|.|:|. ..
Zfish   114 SADPCQDFYQYACGGWVR-KNPLPDGRSRWSTFN---SIWDQNQAVLKHLLENGTFNSSSEAERK 174

  Fly   129 AQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHLSNYGVRSLIH 193
            .|.:|.|||..:......|.| .:.:|..:||:...  ::|:..:|           ..|..:|.
Zfish   175 TQSYYLSCLNEQRIEELGAQP-LMDLITKIGGWNIT--ESWDKENF-----------LDVLKIIS 225

  Fly   194 EEILPQHPFNPYFKLPELGFDHVVHTAHVANTS-------SRAYQL---NEHRMRGYLK------ 242
            .....|    |:|.: .:..|.....::|....       ||.|.|   ||..::.||.
Zfish   226 GPYRAQ----PFFTV-SVSVDPKNSNSNVIQVDQSGLFLPSRDYYLNKTNEKVLKAYLDYMVELG 285

  Fly   243 -----EYNLTKDEISAVIEGVFAFWSEALSIEDKFESDRDKCDL-----LSEIEEVPRFGQWRSY 297
                 :.|.|:.::..:::    |.:...:|....:..||:..:     :::::.:....:|..|
Zfish   286 LLLGGDKNSTRGQMQQILD----FETALANITVPQDERRDEEKIYHKITIADLQVLAPAIEWLDY 346

  Fly   298 YEIAWNGIDFYNGSSGGEFCDFYYVELDKVCAKHTEAVA-NYLAMRFLYR-----------MDDK 350
            .....:.::..:......:...|..::.::..|...::. ||:....:.:           ..||
Zfish   347 LNSVLSPLELNDTEPVVVYAKEYMQQVSELINKTDHSLLNNYMIWNLVQKGASSLDQRFENAQDK 411

  Fly   351 LKE-------------------------------------PKQPEDQKVN-------CLMIVQMT 371
            |.|                                     .||.::..:|       |...|..|
Zfish   412 LLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVKATFDKQSKEIDLNGGAFLPSCGRNVNST 476

  Fly   372 LPNL-FNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIG- 434
            :.|| |:.:..||           .|:.|:|.|.:..|:.::|:|.:||..|..|...|..:||
Zfish   477 VHNLMFSVITQAE-----------GMINEIRTAFKGALDDLKWMDEQTRQAAKDKADAIYDMIGF 530

  Fly   435 ---SYKNEELSDTLIREINNLTIVEGSYAQSLINLRVLGTYLHRYAGLHADELPKD--------T 488
               ...::||.|.    .:...:.|.::.|::||      :.:..|.:.||:|.|.        |
Zfish   531 PDFILDSKELDDV----YDGYEVTEDNFFQNMIN------FYNFSARVMADQLRKPPNRDQWSMT 585

  Fly   489 KPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSS 553
            .|       .|||:|....|.:...||:|..|.|.:..|.:|.||.||.::||||||.||.:|..
Zfish   586 PP-------TVNAYYMPTKNGIVFPAGILQAPFYAQDHPKALNFGGIGVVMGHELTHAFDDQGRE 643

  Fly   554 FDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGY 618
            :|..|.:|.||...|...|:.|.:|.||.:.||.|.  .:.|.|.:|..|||||.|||:||...|
Zfish   644 YDKDGNLRSWWQNSSVEAFKNRTECMVDQYTQYTIN--GEHINGKQTLGENIADNGGLKAAYHAY 706

  Fly   619 RNHMKQLQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDK 682
            |:   .:|::|        :.:::|.::|:.:|||||||||:||:...||...|.| |..|:..|
Zfish   707 RS---WVQKNG--------EEKRLPAVNLTNDQLFFVGFAQVWCSVRTPESAHEGLMTDPHSPPK 760

  Fly   683 YRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            |||:|.:||:.:|||.::|||||.|: ....|.:|
Zfish   761 YRVIGTLSNSPEFAEHFQCPLGSSMN-SGHRCEVW 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	193/748 (26%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	191/745 (26%)
ece2b	XP_017206531.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585582
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950