DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nep7 and MMEL1

DIOPT Version :9

Sequence 1:NP_651603.1 Gene:Nep7 / 43356 FlyBaseID:FBgn0039564 Length:717 Species:Drosophila melanogaster
Sequence 2:NP_258428.2 Gene:MMEL1 / 79258 HGNCID:14668 Length:779 Species:Homo sapiens


Alignment Length:739 Identity:212/739 - (28%)
Similarity:317/739 - (42%) Gaps:147/739 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 MNFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILDIS--YTLMDVTEQLLTRTKLAEALNVSA 124
            |:.:.:||||||:||||.|.          ||..|.:.:  |::.||....|.....|...|.:|
Human   105 MDPTTEPCDDFYQFACGGWL----------RRHVIPETNSRYSIFDVLRDELEVILKAVLENSTA 159

  Fly   125 E----LLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHL-- 183
            :    :..|:..|.||:...:..:..:.| .|.::..:||:| |..|.||.:....:.:...|  
Human   160 KDRPAVEKARTLYRSCMNQSVIEKRGSQP-LLDILEVVGGWP-VAMDRWNETVGLEWELERQLAL 222

  Fly   184 --SNYGVRSLI------HEEILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMRGY 240
              |.:..|.||      .::...:|..  |...|.||.            .||.|..|....|  
Human   223 MNSQFNRRVLIDLFIWNDDQNSSRHII--YIDQPTLGM------------PSREYYFNGGSNR-- 271

  Fly   241 LKEYNLTKDEISAVIEGVFAFW-SEALSIEDKFESDRDKC----DLLSEIE--------EVP--- 289
                        .|.|....|. |.|..:.:.....||.|    |::..:|        .||   
Human   272 ------------KVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEE 324

  Fly   290 RFGQWRSYYEIAWNGIDFYNGSSGGEFCDFYYVELDKVCAK------------------------ 330
            |......|:.:....:....|..|..:..|....|..|..|                        
Human   325 RHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDT 389

  Fly   331 -HTEAVANYLAMRFLYRMDDKLKEPKQP-EDQKVN-----------------CLMIVQMTLPNLF 376
             ....:.|||..|.:.   |::....|. :|.:||                 |:..|...:.|..
Human   390 YSARTIQNYLVWRLVL---DRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAV 451

  Fly   377 NRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIG--SYKNE 439
            ..||:.|.|..:..|.:.:::.::|....:.|:.:.|:|.|::.:|..|...|...||  .|..|
Human   452 GSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILE 516

  Fly   440 ELSDTLIREINNLTIVEGSYAQ-SLINLRVLGTYLHRYAGLHADELPKDTKPLTLLVGMQ-VNAF 502
            |::..|..|.:||...|..|.: ||.||:|       .|.....:|.:...|...::|.. ||||
Human   517 EMNRRLDEEYSNLNFSEDLYFENSLQNLKV-------GAQRSLRKLREKVDPNLWIIGAAVVNAF 574

  Fly   503 YYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRK 567
            |....|.:...||:|.||.:.:..|.:|.||.||.:||||:|||||..|.:||..|.:.||||..
Human   575 YSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNF 639

  Fly   568 SEAVFQERAQCYVDYFNQY---LIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSG 629
            |...|:|:::|.:..:..|   |..|  |.:.|..|..|||||.||:|.|   |:.::|.:...|
Human   640 STQHFREQSECMIYQYGNYSWDLADE--QNVNGFNTLGENIADNGGVRQA---YKAYLKWMAEGG 699

  Fly   630 ADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGAVSNND 693
                    |::|:|||||:.|||||:.:||:||..|.||...:.: |..|:..||||||::.|..
Human   700 --------KDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLA 756

  Fly   694 DFAEVYKCPLGSPMHPKAESCRMW 717
            .||:.:.|..|:||||| |.||:|
Human   757 AFADTFHCARGTPMHPK-ERCRVW 779

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nep7NP_651603.1 PepO 60..717 CDD:226118 211/737 (29%)
M13 66..715 CDD:189000 208/731 (28%)
MMEL1NP_258428.2 PepO 102..779 CDD:226118 211/737 (29%)
M13 111..777 CDD:189000 208/729 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165150999
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3590
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D282463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11733
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.850

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