DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and Ecel1

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_068544.2	Gene:	Ecel1 / 60417	RGDID:	61806	Length:	775	Species:	Rattus norvegicus

Alignment Length:	797	Identity:	199/797 - (24%)
Similarity:	323/797 - (40%)	Gaps:	162/797 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LPLYTRLAVCIL--------ICVILNDC--------EARSIGDESHENAITDETADYLRSHGAMM 58
            ||.:.|..||:|        :|.||...        .|...|....|..  .|...:.|: ...:
  Rat    52 LPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPGAAGTGGACPEGC--PERKAFARA-ARFL 113

  Fly    59 KSYMNFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILD--ISY-TLMDVTEQLLTRTKLAEAL 120
            .:.::.|:|||.|||.||||.|.          ||..|.|  ::| |:..:.||...|.:...|.
  Rat   114 SANLDASIDPCQDFYSFACGGWL----------RRHAIPDDKLTYGTIAAIGEQNEERLRRLLAR 168

  Fly   121 NVSAELLVAQR----FYNSCL----AAELFPRPAADPAYLSVIRSLGGFP---AVDRDA---WNA 171
            ........|||    |:.|||    ...|.|||     .|.||...||:.   |.||..   |:.
  Rat   169 PTGGPGGAAQRKVRAFFRSCLDMREIERLGPRP-----MLEVIEDCGGWDLGGAADRPGAARWDL 228

  Fly   172 -----------SSFSWFNMSAHL-----SNYGVRSLIHEE--ILPQHPFNPYFKLPE-------- 210
                       |:.:.|:::..|     |.|.:|  |.::  .||:...  |....|
  Rat   229 NRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIR--IDQDGLTLPERTL--YLAQDEESEKVLAA 289

  Fly   211 -----------LGFDHVVHTAHVANTSSRAYQLNEHRMRGYLKEYNLTKDEISAVIEGVFAFWSE 264
                       ||.|.|...|      ....||.:......:.||:..:.::|:|...|
  Rat   290 YKVFMERLLRLLGADAVEQKA------QEILQLEQRLANISVSEYDDLRRDVSSVYNKV------ 342

  Fly   265 ALSIEDKFESDRDKCDLLSEIEEVPRFGQWRSYYEIAWNGIDFYNGSSGGEFCDFYYVELDKVCA 329
                            .|.:::::....||:...:..:.. ||............|..::.::..
  Rat   343 ----------------TLGQLQKITPHLQWKWLLDQIFQE-DFSEEEEVVLLATDYMQQVSQLIR 390

  Fly   330 KHTEAVA-NYLAMRFLYRMDDKLKEP---------------KQPEDQKVNCLMIVQMTLPNLFNR 378
            .....:. |||..|.:..:.:.|..|               .:|::....||.............
  Rat   391 STPRRILHNYLVWRVVVVLSEHLSPPFREALHELAKEMEGNDKPQELARVCLGQANRHFGMALGA 455

  Fly   379 LYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKNEELSD 443
            |::.|||:....:::..:|.:::....|.||.::|:||:|:|.|.:|...:..::| |.:..|..
  Rat   456 LFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMVMVG-YPDFLLKP 519

  Fly   444 TLIREINNLTIVEGSYAQSLINLRVLGTYLHRYAGLHADELPKDTKPLTLLVGMQ-VNAFYYNLD 507
            ..:.:.....:.|.:|.::::|      .:.....|...::.::....|.|:..| :||:|....
  Rat   520 EAVDKEYEFEVHEKTYFKNILN------SIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYYLPNK 578

  Fly   508 NSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVF 572
            |.:...||:|.|..|...:|.||.:|.||.:||||||||:|..|..:|.:|.:..||:..|.:.|
  Rat   579 NQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRF 643

  Fly   573 QERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAH 637
            ..:|:|.|..::.:.:  .||.:.|..|..|||||.|||:.|...|:..:::            |
  Rat   644 LHKAECIVRLYDNFTV--YNQRVNGKHTLGENIADMGGLKLAYYAYQKWVRE------------H 694

  Fly   638 KNEQ-MPGLDLSPEQLFFVGFAQLWCADYEPEH-YWEELTGAHTVDKYRVLGAVSNNDDFAEVYK 700
            ..|. :..|..:..||||:.|||.||.....:. |.:.||..|..:.|||||:||..::|...:.
  Rat   695 GPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFH 759

  Fly   701 CPLGSPMHPKAESCRMW 717
            ||..|||:| ...|.:|
  Rat   760 CPKDSPMNP-VHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	184/729 (25%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	182/721 (25%)
Ecel1	NP_068544.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..51
Ecel1	NP_068544.2	M13	121..773	CDD:341056	182/721 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344511
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850