DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and mmel1

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_017213856.1	Gene:	mmel1 / 560703	ZFINID:	ZDB-GENE-101112-2	Length:	765	Species:	Danio rerio

Alignment Length:	793	Identity:	206/793 - (25%)
Similarity:	360/793 - (45%)	Gaps:	137/793 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 YTRLAVCILICVILNDC--------------EARSIGDES---------HENAITDETADYLRSH 54
            :|.:.:.:.:.|:|..|              |..:|.|.|         ..|..|  |...:.:.
Zfish    22 WTVVEIGLSVIVLLMSCALAGLIVLYTSALRERFNINDSSKGLKYRSDADSNVCT--TPQCVTAA 84

  Fly    55 GAMMKSYMNFSVDPCDDFYEFACGNW--KNVKTPRQSPHRRSNIL--DISYTLMDVTEQLLTRTK 115
            ..:::: |:.|||||.:||::|||.|  ::|.....|.|...|||  ::...|..|.|.
Zfish    85 ARLLQN-MDPSVDPCQNFYQYACGGWIERHVIPETSSLHSVFNILRDELEIVLKGVLEM------ 142

  Fly   116 LAEALNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMS 180
              |..:.......|:..|:||:...|..:..:.| .|.:|.|:|.:| |..:.||.:|...:::.
Zfish   143 --ENKDDREAFKKAKTLYSSCMNEILIEQRDSQP-LLRLIDSIGDWP-VASEVWNGTSEQTWSLE 203

  Fly   181 AHLS----NYGVRSLIHEEILPQHPFNPYFKLPELGFDHVVHTAHVA-NTSSRAYQLNEHRMR-- 238
            ..|:    .|..::::...:.|....:..:         ::|....| ...||.|.|::...:
Zfish   204 DTLAVLNGRYNKKAVLEMFVWPDDRDSSRY---------IIHVDQPALGMPSRDYYLSDGNYKKV 259

  Fly   239 --GYL-----------KEYNLTKDEISAVIEGVFAFWSEALSIEDKFESDRDKCDLLSEI----- 285
              .||           ::.|||:||     |.|....|:.|.:|....:.....:..::|
Zfish   260 REAYLEFMVSMARIAREDRNLTQDE-----ERVLEDMSQVLELETDIANATSPAEERNDITVLYN 319

  Fly   286 -----EEVPRFG----QWRSYYEIAWNGIDFYNGSSGGE----FCDFYYVELDKVCAKHT-EAVA 336
                 |....|.    .|..|.:...:.:..  .....|    :|..|..:|.:|.:||: ..:.
Zfish   320 KMTLREAQQTFNLNGFNWTRYIQGIMSSVSI--SVQSDEPIVIYCSPYLEKLSEVLSKHSHRTLQ 382

  Fly   337 NYLA----MRFLYRMDDKLKEPKQ-----------PEDQKVNCLMIVQMTLPNLFNRLYMAEHFT 386
            |||.    |..:..|..:.|:.:.           .|.:..:|:..||..:.|....||:.|.|:
Zfish   383 NYLVWMLIMDRVSSMSRRFKDVRAHYRKALHGTTVEEARWRDCVRYVQGNMENAVGALYVRETFS 447

  Fly   387 DEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKN---EELSDTLIRE 448
            ......:.:::.::::|..:.||.:.|:|.:::.:|..|...|:..|| |.:   ||.:..|.:|
Zfish   448 GNSKRMVGELIKKIQEAYVETLEELSWMDEQSKVKAREKAMAISEQIG-YPDHILEEENKKLDQE 511

  Fly   449 INNLTIVEGSYAQSLI-NLRVLGTYLHRYAGLHADELPKDTKPLTLLVGMQ-VNAFYYNLDNSVY 511
            ..:|...|.:|.:::: ||.......|:       :|.:...|...::|.. |||||.:..|.:.
Zfish   512 YAHLNFSEENYFENILENLAASAQKGHK-------KLREPVDPDMWIIGAAVVNAFYSHNRNQIV 569

  Fly   512 VMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERA 576
            ..||:|.||.:......:|.||.||.:||||:|||||..|.:||..|.:.:|||..|...|::::
Zfish   570 FPAGILQPPFFSEKQLQALNFGGIGMVIGHEITHGFDDHGRNFDKDGNMYNWWSNYSAERFEDQS 634

  Fly   577 QCYVDYFNQYLIPEI-NQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNE 640
            :|.|:.:.::..... .|.:.|..|..|||||.||:|.|   |:.::|.::|.|        :..
Zfish   635 KCMVEQYGRFSWKLAGGQNVSGITTLGENIADNGGVRQA---YKAYVKWVEREG--------EEP 688

  Fly   641 QMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGAVSNNDDFAEVYKCPLG 704
            ::||||::.:||||:.|||:||....||:..:.: |..|:..:|||||::.|.:.|:|.:.|..|
Zfish   689 RLPGLDMNHKQLFFLNFAQVWCGACRPEYAIQTIKTDPHSPLEYRVLGSLQNFEAFSEAFHCARG 753

  Fly   705 SPMHPKAESCRMW 717
            :||:|: |.||:|
Zfish   754 APMNPE-EKCRVW 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	194/721 (27%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	190/713 (27%)
mmel1	XP_017213856.1	PepO	88..765	CDD:226118	194/723 (27%)
mmel1	XP_017213856.1	M13	95..763	CDD:189000	190/713 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585602
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950