DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and PHEX

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	744	Identity:	199/744 - (26%)
Similarity:	328/744 - (44%)	Gaps:	140/744 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 AMMKSYMNFSVDPCDDFYEFACGNW-KNVKTPRQSPH------RRSNILDISYTLMDVTEQLLTR 113
            |.:.|.:|.||||||:|:.|||..| .|...|...|.      .|.|: |:.  |.::.|:.::|
Human    64 AAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNV-DLK--LKELLEKSISR 125

  Fly   114 TKLAEALNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIR-SLGGFPAVDRD-----AWNAS 172
            .:..||:. .|::|     |:||:..:...:..|.| .|.::| |...:|.::.:     .|:..
Human   126 RRDTEAIQ-KAKIL-----YSSCMNEKAIEKADAKP-LLHILRHSPFRWPVLESNIGPEGVWSER 183

  Fly   173 SFSWF-NMSAHLSNYGVRSLIHEEILP------QHPFNPYFKLPELGFDHVVHTAHVAN-TSSRA 229
            .||.. .::.....|.....|...:.|      :|    ..||.:......|...::.| |.:::
Human   184 KFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEH----ILKLDQATLSLAVREDYLDNSTEAKS 244

  Fly   230 YQLNEHRMRGYLKEYNLTKDEISAVIEGVFAFWSE-----ALSIEDKF------------ESDRD 277
            |       |..|  |....|  :||:.|..:..:|     .|.:|.|.            |:..:
Human   245 Y-------RDAL--YKFMVD--TAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYN 298

  Fly   278 KCDLLSEIEEVPRFGQWRSYYEIAWNGID-----FYNGSSGGE---------FCDFYYVELDKVC 328
            |.::......:|:| .|..|.:   ..||     .....|..|         |.|.:.:    :.
Human   299 KMNISELSAMIPQF-DWLGYIK---KVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRI----LG 355

  Fly   329 AKHTEAVANYLAMRFLYRMDDKLKEPKQ-----------------PEDQKVNCLMIVQMTLPNLF 376
            ::..:.:||||..|.:|.....|....|                 |:..|  |:..::..||.:.
Human   356 SERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDK--CVNFIESALPYVV 418

  Fly   377 NRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESV-EWLDAETRAEALSKEAGITPVIGSYKNEE 440
            .::::..:|.::|...:.::|..:|.|...:||.. ||:||.|:.:|..|...:...:| |....
Human   419 GKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVG-YPEFI 482

  Fly   441 LSDTLIRE-INNLTIVEGSYAQSLINLRVLGTYLHRYAGLHAD------ELPKD---TKPLTLLV 495
            ::||.:.| :..:...|..|..:::..|   .||     ..:|      .:||.   |.|.|
Human   483 MNDTHVNEDLKAIKFSEADYFGNVLQTR---KYL-----AQSDFFWLRKAVPKTEWFTNPTT--- 536

  Fly   496 GMQVNAFYYNLDNSVYVMAGVLHPPAY-HRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGE 559
               |||||....|.:...||.|..|.: ...:|.||.:|.||.::|||.|||||..|..:|..|.
Human   537 ---VNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGN 598

  Fly   560 VRDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQ 624
            :..|||.:||..|:|:.:|.::.::.|...:....::|..|..|||||.||||.|...||..:..
Human   599 LDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWIND 663

  Fly   625 LQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGA 688
             :|.|.: |.|      :||:..:..||||:.:|.:.|..|.||...|:: .|||:..::||.||
Human   664 -RRQGLE-EPL------LPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGA 720

  Fly   689 VSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            :||.::|.:.:.||..|.|:...:|||:|
Human   721 ISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	197/738 (27%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	192/730 (26%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	192/730 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920