DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and Nepl18

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	777	Identity:	201/777 - (25%)
Similarity:	321/777 - (41%)	Gaps:	189/777 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LAVCILICVILNDCEARSIGDESHENAITDETADY-----LRSHGAMMKSYMNFSVDPCDDFYEF 75
            |.:|:|:.::....:....||...:    |.|:||     :::..|.||:.|...|.||||||..
  Fly     7 LWLCLLVAIVPAMAKPSDAGDPFAD----DLTSDYAKKIIVQAKVAEMKTMMKPEVSPCDDFYTH 67

  Fly    76 ACGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTR------TKLAEALNVSAEL-LVAQRFY 133
            |||||           .|.|...:...:|....:|:::      .:|..|.::.:|| ...||||
  Fly    68 ACGNW-----------HRHNPAQLLGDVMTDNFKLISKGFDRRLQRLLRANDLQSELEKKMQRFY 121

  Fly   134 NSC-----------LAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHLSN-Y 186
            .||           ||.|            :|||..|..||:....||:|.|||:...|.:.: |
  Fly   122 MSCNLVHRDDVHYKLALE------------NVIREYGTLPALVGAQWNSSDFSWWRTVAQIQHKY 174

  Fly   187 GVRSLIHEEILPQHPFNPYFKLPELGFDHVVHTAHVANTS-SRAY-------QLNEHRMRGYLKE 243
            |.:.:|..||:..                      :.||| :|.|       .:|. |:...::|
  Fly   175 GKQIIIGLEIMHD----------------------IRNTSVNRVYISQPDFKTINT-RLTNLMEE 216

  Fly   244 YNLTKD--EISAVIEGVFAFWSEALS-IEDKFESDRDKCDLLSEIEEVPRFGQWRSYYEIAWNGI 305
            ...:.|  :...:...|....:|.|: :|..|.|.......|.|...:......:..|....|..
  Fly   217 VRTSMDLQQYFGLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLYTVADLQEKYSDHLNFT 281

  Fly   306 DFYNGSSGGE-------FCDFYYVELDKVCAKHTEAV--ANYLAMRFLYRMDDKLKEPKQPEDQK 361
            :|.....|.|       ..|..|::...:..:.|...  |||:..:.|   :|.|.: .||:|..
  Fly   282 EFLGLILGEENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLWKLL---EDFLVD-AQPKDMV 342

  Fly   362 VNCLMIVQMTLPNLFNRLYMAEHFTDEKHSEISDMVTEMRK---------AQRQILESVEWLDAE 417
            ..|    ..:....|.:|  |||...:::.. .|:.:|:.|         .||.:.:.::|:...
  Fly   343 KWC----TESTKKYFGKL--AEHAVYKRYRN-PDVESEVHKIWDQIKGIFRQRLLGDKLDWISNA 400

  Fly   418 TRAEALSKEAGITPVIGSYKNEELSD----------TLIREINNLTIVEGSYAQSLINLRVLGTY 472
            ||..|:.|...:...|.||..|...:          ..:..:..|.|.:|....:.||
  Fly   401 TRTLAIEKLERMHLNINSYDEENFENVYGEVFIDRLNYVSNVQQLLIAKGIRFVARIN------- 458

  Fly   473 LHRYAGLHADELPKDTKPLTLLVGMQVNAFYYNL-DNSVYVMAGVLHPPAYHRSW----PDSLKF 532
                       .|.|:...|.|:|...   .||: :|::.:...:|.|..:   |    |::||:
  Fly   459 -----------QPADSVDATELLGFTP---AYNIQENNITIPVALLQPRYF---WGDQYPEALKY 506

  Fly   533 GTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQY-----LIPEIN 592
            .|:|||:.||:.||||.:|..:|::|.:..||..||...|:||.:|:...:::|     .:||
  Fly   507 ATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKLPE-- 569

  Fly   593 QTIRGNETRDENIADAGGLRAALTGYRNHMKQ-----LQRSGADGETLAHKNEQMPGLDLSPEQL 652
                 ::.:.|||||:|||:.|...|...:.|     |||            |.|.||..:..||
  Fly   570 -----SKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQR------------ETMEGLPFNSRQL 617

  Fly   653 FFVGFAQLWCAD----YEPEHYWEELTGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPK 710
            ||:|:|||.|.|    ::|   |...:..|...||||:|.:||..:|..|:.|...:||.|:
  Fly   618 FFLGYAQLLCDDVQFLFQP---WVSQSDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPE 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	189/728 (26%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	188/722 (26%)
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	189/726 (26%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	188/722 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451250
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4162
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800