DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and Nep5

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster

Alignment Length:	867	Identity:	204/867 - (23%)
Similarity:	351/867 - (40%)	Gaps:	219/867 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLSISSYFRLPLYTR--------LAVCILICVILNDCEARSIGDESHENAITDETADYLRSHGAM 57
            ::.|.|.||...|.:        |.:.:||.:|:     .|:|.:...:..  .:.:.||:..::
  Fly    85 LIGIQSKFRRSYYHKVVLGGLLALVIILLIAIIV-----ISLGLKKSSSIC--RSKECLRTAASL 142

  Fly    58 MKSYMNFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRTKLAEALNV 122
            :.: |:...|||:|||:|.||.|.|       .|.|.:         .||.....|.:.|..:.|
  Fly   143 IYA-MDEQTDPCEDFYQFTCGRWAN-------EHPRPD---------SVTSNDWFRERQAHIMRV 190

  Fly   123 SAELL-------------VAQRFYNSCLAAELFPRPAADPAYLSVIR------------SLGGFP 162
            ..|.|             .|:..|.:|:..:|..:...:|....::|            :||...
  Fly   191 VREFLRSNITKSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLTLGSGS 255

  Fly   163 AVDRDAWNASSFSWF----NMSAHLSNYGVRSLIHEEILPQHPFNPYFKLPELGFDHV------- 216
            ....:|.|. .::|.    ::..||:   :..:|..::.|. |||.......||....
  Fly   256 KYATEAANV-KYNWLQSIVSIKQHLT---MDLIIGFDVFPD-PFNRTINRIALGTPETDSAFPFN 315

  Fly   217 ----------VH-------------------------TAHVANTSSRAYQLNEHRMRGYLKEY-- 244
                      :|                         .|...:|...||.   |.:|..:::|
  Fly   316 NDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYL---HYVRKVIEKYLL 377

  Fly   245 ----NLTKDEIS-----------AVIEGVFAFWSEALSIEDKFESDRDKC------DLLSEIEE- 287
                |:.::|.:           .|...|..|..||.::....::..|..      ||.::.::
  Fly   378 YVDPNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVYITLQDLQNQTDKN 442

  Fly   288 -VPR-FGQWRSYYEIAWNGIDFYNGSSGGEF------------CDFYYVE-----LDKVCAKHTE 333
             .|: ...|..|.|:...|.     ...|..            .|..|::     ||...|.|.|
  Fly   443 IAPKTLPIWVRYMELILKGT-----RHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIE 502

  Fly   334 AVANYL--------------AMRFLYRMDDKL---KEPKQPEDQKVNCLMIVQMTLPNLFNRLYM 381
               :||              :||.|:....::   .|...|  :.:.|...|...|....:.:..
  Fly   503 ---SYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTP--RSLYCANGVNSLLGMAVSYVLA 562

  Fly   382 AEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKNEELSDTLI 446
            ...||.||..::..|::::|::..::::|..|:||.|:.:.:.|.|.:...||          ..
  Fly   563 DADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIG----------FP 617

  Fly   447 REINNLTIV----EGSYAQSLINLRVLGTYLHRYAGLHADELPKD------TKPLTLLVGMQVNA 501
            ..:.|.:::    ||:...:..:|..|..::|.......:|:.|.      |.|      ..|||
  Fly   618 PWLRNASVLNAYYEGAEVNASTHLENLMDFVHWQMMDKLNEMDKPEPIGWATSP------SNVNA 676

  Fly   502 FYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSR 566
            |:....|::.|...:|..|.|.... ::|.:|:||.::|||||||||..|..||.||.:.:|||.
  Fly   677 FHTFQSNAITVPIAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSN 740

  Fly   567 KSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGAD 631
            ::...:..|.:|:|:.:::|.:.:|::.|.|..|..|||||.||:|.|...||.::|::.|
  Fly   741 RTIDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGR---- 801

  Fly   632 GETLAHKNEQMPGLD-LSPEQLFFVGFAQLWCADYEPEHYWEELTGAHTVDKYRVLGAVSNNDDF 695
                  :..::|||: .|.|||||:.|..|||..|.|......||.:|...:.|:.|.:||:::|
  Fly   802 ------ERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYALTDSHCPGQMRLRGVLSNSEEF 860

  Fly   696 AEVYKCPLGSPMHPKAESCRMW 717
            |..:||..|:||:|....||:|
  Fly   861 ARTFKCARGTPMNPDQPKCRIW 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	190/798 (24%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	187/790 (24%)
Nep5	NP_733186.2	PepO	146..882	CDD:226118	190/796 (24%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	187/789 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4162
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.870