DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and MME

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	809	Identity:	201/809 - (24%)
Similarity:	354/809 - (43%)	Gaps:	186/809 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PLYTRLAVCILICVILNDCEARSIGDESHENAIT--------DE----TADYLRSHGAMMKSYMN 63
            ||...|:|.:|:..|:               |:|        |:    ::|.::|...:::: |:
Human    26 PLEISLSVLVLLLTII---------------AVTMIALYATYDDGICKSSDCIKSAARLIQN-MD 74

  Fly    64 FSVDPCDDFYEFACGNW--KNVKTPRQSPHRRSNIL--DISYTLMDVTEQLLTRTKLAEALNVSA 124
            .:.:||.||:::|||.|  :||.....|.:...:||  ::...|.||.::..|...:|
Human    75 ATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVA------- 132

  Fly   125 ELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWN---ASSFSWFNMSAHL-SN 185
             :..|:..|.||:..........:| .|.::..:.|:| |..:.|.   .:|::.....|.| |.
Human   133 -VQKAKALYRSCINESAIDSRGGEP-LLKLLPDIYGWP-VATENWEQKYGASWTAEKAIAQLNSK 194

  Fly   186 YGVRSLIHEEILPQHPFNPYFKLPELGFD------HVVHTAHVANTSSRAYQLNEHRM----RGY 240
            ||.:.||:..:               |.|      ||:|             :::.|:    |.|
Human   195 YGKKVLINLFV---------------GTDDKNSVNHVIH-------------IDQPRLGLPSRDY 231

  Fly   241 LKEYNLTKDEISAVIEGVFAFWSEALSIEDKFESDRDKCDL-LSEIEEVPR-------------- 290
            .:...:.|:..:|.::.:.:. :..:..|::...|.::..| ::::.|:.:
Human   232 YECTGIYKEACTAYVDFMISV-ARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRND 295

  Fly   291 ---------FGQWRSYYEIAWNGIDF------------YNGSSGGE-----FCDFYYVELDKVCA 329
                     ..|.::.:.:..||..|            .|.|...|     :...|..:|..:..
Human   296 PMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT 360

  Fly   330 KHT-EAVANYLAMRFLYRMDDKL----KEPKQPEDQKV-----------NCLMIVQMTLPNLFNR 378
            |:: ..:.|.::.||:..:...|    ||.:....:.:           .|...|...:.|...|
Human   361 KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGR 425

  Fly   379 LYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKNEELSD 443
            ||:...|..|....:.|::.::|:...|.|:.:.|:||||:..|..|...|...|| |.::.:|:
Human   426 LYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIG-YPDDIVSN 489

  Fly   444 TLIREINN----LTIVEGSYAQSLI-NLRVLGTYLHRYAGLHADELPKDTKPLTLLVGMQ----- 498
            .  .::||    |...|..|.:::| ||:.              ...|..|.|...|...
Human   490 D--NKLNNEYLELNYKEDEYFENIIQNLKF--------------SQSKQLKKLREKVDKDEWISG 538

  Fly   499 ---VNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEV 560
               |||||.:..|.:...||:|.||.:.....:||.:|.||.:||||:|||||..|.:|:..|::
Human   539 AAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603

  Fly   561 RDWWSRKSEAVFQERAQCYV-DYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQ 624
            .|||:::|.:.|:|::||.| .|.|........|.:.|..|..|||||.|||..|...|:|::|:
Human   604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKK 668

  Fly   625 LQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGA 688
                  :||     .:.:|||||:.:||||:.|||:||..|.||:....: |..|:...:|::|.
Human   669 ------NGE-----EKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGT 722

  Fly   689 VSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            :.|:.:|:|.:.|...|.|:|: :.||:|
Human   723 LQNSAEFSEAFHCRKNSYMNPE-KKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	189/746 (25%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	186/738 (25%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	186/736 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150936
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4162
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.800