DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and Nep4

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster

Alignment Length:	829	Identity:	220/829 - (26%)
Similarity:	345/829 - (41%)	Gaps:	223/829 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 MKSYMNFSVDPCDDFYEFACGNWKNV------------------------------KTP------ 86
            ||.||:..||||.|||::|||||:.:                              .||
  Fly   266 MKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAE 330

  Fly    87 -RQSPHRRSNILDISYTLMDVTE---------------------------QLLT----------- 112
             |:||.|.        ||..:.|                           |||.
  Fly   331 LRKSPVRN--------TLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTN 387

  Fly   113 -------------RTKLAEA--------------------LNVSAEL--------LVAQRFYNSC 136
                         |||..||                    |:|..:.        |.|:..|.||
  Fly   388 GTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSC 452

  Fly   137 LAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHLSNYGVRSLI--------- 192
            :.:.:..:...:|.: ::||.|||:|.:: ..|:.|:|:|..::|.|..|....||
  Fly   453 VNSAVLAKRGLEPLH-TLIRELGGWPVLE-SQWSESNFNWQVLAATLRRYNNDILIVQWVGADIK 515

  Fly   193 -HEEILPQH-------PFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMRGYLKEYNLTKD 249
             .||.:.|.       |...||..|               ::::..|..:..|...:.:...:|.
  Fly   516 NSEENIVQFDQTGLGLPTREYFLQP---------------SNAKYLQAYQRYMAEVMHKMGASKA 565

  Fly   250 EISAVIEGVFAFWSEALSIEDKFESDRDKCDL-----LSEIEEVPRFGQWRSYYEIAWNGIDFYN 309
            :...|...:.||.::...|....|...:...|     |.:::.|....:||:|.:...:     .
  Fly   566 DAQRVASELVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQD-----R 625

  Fly   310 GSSGGEFCDFYYVE--------LDKVCAKHTEAVANYLAMRF----LYRMDDKLKEPKQ------ 356
            ...|.|....|.||        ||:.   ....|:||:..||    :..:||:..:.||
  Fly   626 EVLGTEEVVIYAVEYMSKLVTLLDET---DPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHAL 687

  Fly   357 ------PEDQKVNCLMIVQMTLPNLFNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLD 415
                  |:..|| |:..|...:......::::.:|.:....:...|..::::|.|.||::.:|||
  Fly   688 FGREESPQRWKV-CIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDILKTTDWLD 751

  Fly   416 AETRAEALSKEAGITPVIGSYKNEELSDTLIREINN----LTIVEGSYAQSLINLRVLGTYLHRY 476
            ..|:..|..|...::..|| |.:..|:.:   |:|:    :.|....|.::.:|: :|.|.....
  Fly   752 DTTKQLAEEKVNAMSLKIG-YPDFILNPS---ELNSKYAGIEIYPEKYFENTLNV-LLHTAKTEQ 811

  Fly   477 AGLH--ADELPKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLI 539
            |.||  .::....|.|..      |||:|....|.:...||:|.||.|||.:|.||.||.||.:|
  Fly   812 AKLHERVNKTNWQTAPAI------VNAYYSRNKNQIMFPAGILQPPFYHRHFPKSLNFGGIGVVI 870

  Fly   540 GHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDEN 604
            |||||||||.:|..||..|.:..||:..|...|.|||:|.:..::.|.:.|:...:.|..|:.||
  Fly   871 GHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGEN 935

  Fly   605 IADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEH 669
            |||.||||.|...|:..:|:.....:|        |.:|||:::..||||:.|.|:||....||.
  Fly   936 IADNGGLRQAFHAYQRWLKEHPSEVSD--------EILPGLNMTGPQLFFLNFGQVWCGAMRPEA 992

  Fly   670 YWEEL-TGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            ...:| |..|:..::||:|.:||:.|||..:.|||||||:|: :.|.:|
  Fly   993 IRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQ-KKCSVW 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	217/825 (26%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	214/817 (26%)
Nep4	NP_650904.3	M13	274..1038	CDD:189000	214/817 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454991
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850