DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and Ece2

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_006248635.1	Gene:	Ece2 / 408243	RGDID:	1303039	Length:	912	Species:	Rattus norvegicus

Alignment Length:	785	Identity:	210/785 - (26%)
Similarity:	346/785 - (44%)	Gaps:	147/785 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SYFRLPLYTRLAVCILICVILNDCEARSI---GDESHENAITDETADYLRSHGAMMKSYMNFSVD 67
            |:.:|.|.....:.:|..::|....|..:   .|..|...||:..   :|..|.:::| ::..|.
  Rat   202 SHTQLELVLAGLILVLAALLLGCLVALWVQYHRDPVHSTCITEAC---IRVAGKILES-LDRGVS 262

  Fly    68 PCDDFYEFACGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRTKLAEALNVSAELLVAQR- 131
            ||.|||:|:||.|.. :.|..|...|.|..:   :|.|..:.:|.........|.|:|   |:|
  Rat   263 PCQDFYQFSCGGWIR-RNPLPSGRSRWNTFN---SLWDQNQAILKHLLENSTFNSSSE---AERK 320

  Fly   132 ---FYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHLSNYGVRSLIH 193
               ||.|||..|...:..|.|.. .:|..:||:...  ..|:..:|.
  Rat   321 TRSFYLSCLHLERIEKLGAKPLQ-DLIDKIGGWNIT--GPWDEDNFM------------------ 364

  Fly   194 EEILP----QHPFNPYFKLPELGFDHVVHTAHVANTS-------SRAYQL----NEHRMRGYLKE 243
             |:|.    .:...|:|.: .:|.|.....:::....       ||.|.|    ||..:..|| :
  Rat   365 -EVLKAVAGTYRAAPFFTV-YVGADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLAAYL-D 426

  Fly   244 YNLTKDEISAVIEG----VFAFWSEALSIEDKF-------ESDRDKCDL-----LSEIEEVPRFG 292
            |.:   |:..::.|    ..|...:.|.:|.:.       :..||:..:     :||::.:....
  Rat   427 YMV---ELGMLLGGQPTSTRAQMQQVLELEIQLATITVPQDQRRDEEKIYHKMSISELQTLAPSM 488

  Fly   293 QWRSYYEIAWNGIDFYNGSS------GGEFCDFYYVELDKVCAKHTE--AVANYLAMRFLYRMDD 349
            .|..:.....:.::.  |.|      |.|     |::........||  .:.|||....:.:...
  Rat   489 DWLEFLSFLLSPLEL--GDSEPVVVYGTE-----YLQQVSELINRTEPSILNNYLIWNLVQKTTS 546

  Fly   350 KLKEPKQPEDQKV----------------NCLMIVQMTLPNLFNRLYMAEHFTDEKHSEISD-MV 397
            .|.:..:...:|:                .|:......|......|::...| |.:..||:: |:
  Rat   547 SLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATF-DRQSKEIAEGMI 610

  Fly   398 TEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKNEELSDTLI--REINNL----TIVE 456
            :|:|.|..:.||::.|:|.:||..|..|...|..:||      ..|.::  ||::::    .:.|
  Rat   611 SEIRAAFEETLENLVWMDEKTRLAAKEKADAIYDMIG------FPDFILEPRELDDVYDGYEVSE 669

  Fly   457 GSYAQSLINLRVLGTYLHRYAGLHADELPK-DTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPP 520
            .|:.|:::||      .:..|.:.||:|.| .::....:....|||:|....|.:...||:|..|
  Rat   670 DSFFQNMLNL------YNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAP 728

  Fly   521 AYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQ 585
            .|..:.|.:|.||.||.::||||||.||.:|..:|..|.:|.||..:|...||....|..:.:||
  Rat   729 FYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNLRPWWQNESLTAFQNHTACMEEQYNQ 793

  Fly   586 YLIPEIN-QTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQ-MPGLDLS 648
            |   ::| :.:.|.:|..|||||.|||:||...|:..:::            |..|| :|.:.|:
  Rat   794 Y---QVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRK------------HGEEQPLPAVGLT 843

  Fly   649 PEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAE 712
            ..|||||||||:||:...||...|.| |..|:..::||||.:||:.||...:.||:||||:| .:
  Rat   844 NHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNP-GQ 907

  Fly   713 SCRMW 717
            .|.:|
  Rat   908 LCEVW 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	197/726 (27%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	195/718 (27%)
Ece2	XP_006248635.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	250..903	CDD:226118	194/722 (27%)
		M13	261..910	CDD:189000	195/718 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344501
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850