DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and Nepl6

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	750	Identity:	166/750 - (22%)
Similarity:	283/750 - (37%)	Gaps:	145/750 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LAVCILICVILNDCEARSIGDESHENAITDETADYLRSHGAMMKSYMNFSVDPCDDFYEFACGNW 80
            |..|:.|..|   |.|     .:.:|...|..:..:.:    :.||:......|..::::|||
  Fly     3 LIACLFIVPI---CAA-----PTTQNVEADPNSRLMNN----ILSYVAEDSSACGTYFQYACG-- 53

  Fly    81 KNVKTPRQSPHRR-SNILD--ISYTLMDVTEQLLTRTKLAEALNVSAELLVAQRFYNSCLAAELF 142
            |.....|..|... ..:||  ::..|:.:..:|..|:: :...|.|:.......||.:|..|.
  Fly    54 KYAVRHRDDPFTEIIQMLDHKVNGNLVQLMHELHQRSQ-SPGFNESSVEAKVLHFYRTCREAP-- 115

  Fly   143 PRPAADPAYLSVI---RSLGGFPAVDR-DAWNASSFSWFNMSAHLSNYGVRS-LIHEEILPQHPF 202
            |.......||.:.   ::|.....:.| :.|..:.|.|.....||..||..: |::..:|.....
  Fly   116 PSTRKMEHYLRLAPPGQALTWPQFMPRGEPWPKAQFKWMKSLGHLYRYGFTNVLVNVLVLRSSEN 180

  Fly   203 NPYFKL----PEL--------GFDHVVHTAHVANTSSRAYQLNEHRMRGYLKEYNLTKDEISAVI 255
            :..|:|    |.|        ||...:.|..:....:::......::|.               :
  Fly   181 SNRFRLDISMPSLEGDAQHLGGFLSTLATLQIIGVPTKSILPLVRKIRR---------------L 230

  Fly   256 EGVFAFWSEALSIEDKFESDRDKCDLLSEIEEVPRFGQWRSYYEIAWNGIDFYNGSSGGEFCDFY 320
            |......:|   ::|..||            |.....||......||.|  |.....|......|
  Fly   231 ESAIRVLTE---VDDDDES------------ETWTLRQWEYKTGYAWQG--FVESIVGHSVSHHY 278

  Fly   321 YVELDKVCAKH------------TEAVANYLAMRF-LYRMDDKLKEPKQPEDQKVNCLMIVQMTL 372
            .::...  ||:            .|.||||:..|| ||.:||.:     ..::.::|:..::..:
  Fly   279 VMQAQN--AKYFTGLKRLMDSTDAEVVANYIMTRFVLYLIDDFI-----DSNEHIDCVTDMRRNM 336

  Fly   373 PNLFNRLYMAEHFTD-----EKHSEISDMVTEMRKA-QRQILESVEWLDAETRAEALSKEAGITP 431
             ||.:.|...|.|.|     :...|::.:..::|:. ..||.|:...|.:|..:...:|...:..
  Fly   337 -NLASNLLYKERFLDPATLQQYTQEVTKVFEQLRRQFLLQINENRLGLTSEQNSMVATKAQHVVL 400

  Fly   432 VIGSY-KNEELSDTLIREINNLT--IVEGSYAQSLINLRVLGT-----YLHRYAGLHADELPKDT 488
            .||:. :..:....:.|...:|.  :.:..||:..:||....|     .|::.|.. .||....:
  Fly   401 NIGNLPRGRDHRSFVSRHYEDLVFPLPDFDYAREHLNLLEFRTRKQVLQLNQSAPT-PDEFFYLS 464

  Fly   489 KPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSS 553
            .|.|   .|....:|....|.:.|..|:|..|.:.....|..|:..:|:::.|||.|..||.|..
  Fly   465 DPKT---AMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSVDTVGLY 526

  Fly   554 FDSAGEVRDWWSR-KSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTG 617
            :|..|.:.:...: .|...|....||......|||              ||.|||..||..|.:.
  Fly   527 YDRYGNIHEIGPQISSSPRFVAGLQCLNRNSTQYL--------------DERIADIAGLDLAYST 577

  Fly   618 YRNHMKQLQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEELTGAHTVDK 682
            |..:..|:  |..|..|            :.|:|:||:..||.:|.|.:|.::     ..|..|:
  Fly   578 YFQNSSQM--SLTDFTT------------IPPQQIFFLNLAQFFCGDGDPINF-----VGHDNDE 623

  Fly   683 YRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            .|:...::....|.|.:.||..|   .:.|.|::|
  Fly   624 TRLQQMLNGFAPFHEAFGCPAKS---NQPEKCQLW 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	157/704 (22%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	154/696 (22%)
Nepl6	NP_609023.3	M13	42..653	CDD:189000	154/695 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840