DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and goe

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001285350.1	Gene:	goe / 32660	FlyBaseID:	FBgn0027528	Length:	879	Species:	Drosophila melanogaster

Alignment Length:	830	Identity:	166/830 - (20%)
Similarity:	268/830 - (32%)	Gaps:	278/830 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLSISSYFRLPLYTRLAVC---ILICVILNDCEARSIGDESHENAITDETADYLRSHGAMMKS-- 60
            ::|:|...|:...|...:|   :||.::|              .|...|...|||:...:.|.
  Fly   119 LMSLSRKRRILYVTTACLCALLLLIIILL--------------LAFWPEVPFYLRAPLCLDKECV 169

  Fly    61 --------YMNFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILDI-----SYTLMDVTEQL-- 110
                    :.|.|..||.:.||:||||:       .|.:.......|     :|...:..::|
  Fly   170 ESSRQLLLWANTSKSPCHETYEWACGNF-------ASDYANHEYFVIKRGEWNYETYNEYQELNE 227

  Fly   111 LTR--TKLAEALNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASS 173
            |.|  ..|..:...|.|..|:. .|.||...::..:..:|......|.::.|        |.|
  Fly   228 LNRFIAMLPNSQEGSVESTVSS-LYRSCRETDVLDKSQSDLLLKRAINAVYG--------WQA-- 281

  Fly   174 FSWFNMSAHLSNYGVRSLIHEEILPQHPFNPYFKLP-ELGFDHVVHTAHVANTSSRAYQLNEHRM 237
               |..|..|.::..:.:: ..:..:|...||:::. |.||.                  |.|
  Fly   282 ---FRDSNRLQSWEYKRVL-VVLQAKHGIFPYYRVTVENGFS------------------NPH-- 322

  Fly   238 RGYLKEYNLTKDEISAVIEGVFAFWSEALSIEDK--FESDRDKCDLLSEIEEVPRFGQWRSYYEI 300
                 :|.:|.||             ..|.:.||  :.:|.|        |||.|      .|::
  Fly   323 -----DYVITLDE-------------GELGLPDKYFYGNDAD--------EEVVR------GYKL 355

  Fly   301 AWNGIDFYNGSSGGE---FCD--FYYVELDKVCAKHTE---AVANYLAMRFLYRMDDKLKEPKQP 357
            .........|....|   |.|  |:|   ::....|.|   |.||....:.:...|.|:|.|..|
  Fly   356 LLRDFAINMGIVSREADLFADDIFHY---ERRIVNHIEDAKADANRPINKLMRLADLKIKAPSLP 417

  Fly   358 ---------------EDQKVNCLMIVQMTLPNLFNRLYMAEHFTDEK-------HSEISDMVTEM 400
                           ||.:|    :|:.  |.:.:.|.:....:|:|       .|....|:..:
  Fly   418 ILESLQAIFPKTKITEDTEV----LVRD--PEVMHALSVLLSTSDKKPINNFIVWSLARKMLPHL 476

  Fly   401 RKAQRQILESV----------------------EWL----DA----------ETRAEALSKEAGI 429
            .|..|.:.|:.                      :||    ||          ||..   ||..|:
  Fly   477 SKEYRTLAETFDHALYGRTASYPRWLICSKVVRDWLPFAVDALQQQPPRQQFETMT---SKSRGL 538

  Fly   430 TPVIGSYKNEELSDTLIREINN-----------LTIVEGSYAQSLINLRVL-----------GTY 472
            ....|   ||||...:...:.|           |......:.|..:|...|           .||
  Fly   539 NKTQG---NEELLKLMFFSLRNQLKDSLEQAKWLEPAARQFIQKKLNEMRLQFGIPDEVLQQPTY 600

  Fly   473 LHRYAG------------------LHADELPKDTKPLTLLVGMQVNAF---------YYNLDNSV 510
            |.:|..                  ....::.|...||.:|..:....:         |.|..|.:
  Fly   601 LAQYYNELILNNVFFVEHLEWIWTFRRSQMEKKLGPLAILDVIVSEMYTRDNPQAIAYSNKLNML 665

  Fly   511 YVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSF--------DSAGEVRDWWSRK 567
            .|...::....|...:|.::.|..||..|...|...|.|....|        |:|.|:|
  Fly   666 LVSKVLISSNYYDYRYPVAVNFARIGTDILEALIDNFSTFLLQFNTQSTDISDAAPEIR------ 724

  Fly   568 SEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRA--ALTGYRNHM---KQLQR 627
               ..|....|........|:.|:|: :..|..:..::..:....|  ||:.:.|.:   ..:|.
  Fly   725 ---YAQPDVNCLAAGQPPRLVHELNE-LSSNALKSFHVTLSAARTAARALSNFVNAIDAGSAIQG 785

  Fly   628 SGADG----ETLA-HKNEQMPGL-DLSPEQLFFVGFAQLWCA------DY 665
            ||.|.    |.|. .:..::||| ..:..:||.:.:.|..|:      ||
  Fly   786 SGIDQANTYEALGLTRRLRIPGLRSFNENELFTLSYMQQHCSTTIADKDY 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	152/768 (20%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	150/752 (20%)
goe	NP_001285350.1	GluZincin	184..>694	CDD:301352	116/598 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454917
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840