DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and Mmel1

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001101467.2	Gene:	Mmel1 / 313755	RGDID:	1309299	Length:	774	Species:	Rattus norvegicus

Alignment Length:	770	Identity:	210/770 - (27%)
Similarity:	337/770 - (43%)	Gaps:	152/770 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RSIGDESHENAITDETADYLRSHGAMMKSYMNFSVDPCDDFYEFACGNW-KNVKTPRQSPHRRSN 95
            |.:.|.|.::.|....:..:.:  |.:...|:.|..|||:||::|||.| ::...|  ..:.|.:
  Rat    73 RVLRDSSQKSDICTTPSCVIAA--ARILQNMDQSKKPCDNFYQYACGGWLRHHVIP--ETNSRYS 133

  Fly    96 ILDISYTLMDVTEQLLTRTKLAEALNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGG 160
            :.||   |.|..|.:|.......::.....:..|:..|.||:...:..:..::| .|:|:..:||
  Rat   134 VFDI---LRDELEVILKGVLEDSSVQHRPAVEKAKTLYRSCMNQSVIEKRDSEP-LLNVLDMIGG 194

  Fly   161 FPAVDRDAWNASSFSWFNMSAHL----SNYGVRSLI------HEEILPQHPFNPYFKLPELGFDH 215
            :| |..|.||.:....:.:...|    |.:..|.||      .::...:|..  |...|.||.
  Rat   195 WP-VAMDKWNETMGPKWELERQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVI--YIDQPTLGM-- 254

  Fly   216 VVHTAHVANTSSRAYQLNE--HRMR-GYLK-----------------EYNLTKDEISAVIEGVFA 260
                      .||.|...|  ||:| .||:                 |.:|.::|::.|
  Rat   255 ----------PSREYYFKEDSHRVREAYLQFMTSVATMLRRDLNLPGETDLVQEEMAQV------ 303

  Fly   261 FWSEALSIEDKF-------ESDRDKCDL-----LSEIEEVPRFG----QWRSYY----------- 298
                 |.:|...       |...|...|     |.|::|  |||    .|..:.
  Rat   304 -----LHLETHLANATVPQEKRHDVTALYHRMGLEELQE--RFGLKGFNWTLFIQNVLSSVQVEL 361

  Fly   299 ----EIAWNGIDFYNGSSGGEFCDFYYVELDKVCAKHTEAVANYLAMRFLY----RMDDKLKEPK 355
                |:...||.:.....  |..|.:          ..:.:.|||..|.:.    .:..:.||.:
  Rat   362 LPNEEVVVYGIPYLENLE--EIIDVF----------PAQTLQNYLVWRLVLDRIGSLSQRFKEAR 414

  Fly   356 -----------QPEDQKVNCLMIVQMTLPNLFNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILE 409
                       ..|.:...|:..|...:.:....||:...|:.:..|.:|:::.::|......|:
  Rat   415 VDYRKALYGTTMEEVRWRECVSYVNSNMESAVGSLYIKRAFSKDSKSIVSELIEKIRSVFVDNLD 479

  Fly   410 SVEWLDAETRAEALSKEAGITPVIG--SYKNEELSDTLIREINNLTIVEGSYAQS-LINLRVLGT 471
            .:.|:|.|::.:|..|...|...||  .|..|:.:..|..|.::||..|..|.:: |.||:
  Rat   480 ELNWMDEESKKKAQEKALNIREQIGYPDYILEDNNRHLDEEYSSLTFSEDLYFENGLQNLK---- 540

  Fly   472 YLHRYAGLHADEL-PKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTI 535
               ..|.....:| .|..:.|.::....|||||....|.:...||:|.||.:.:..|.:|.||.|
  Rat   541 ---NNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNLIVFPAGILQPPFFSKDQPQALNFGGI 602

  Fly   536 GYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEI--NQTIRGN 598
            |.:||||:|||||..|.:||..|.:.||||..|...|::::||.:..::.:.. |:  ||.:.|.
  Rat   603 GMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFRQQSQCMIYQYSNFSW-ELADNQNVNGF 666

  Fly   599 ETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCA 663
            .|..|||||.||:|.|   |:.:::.|...|.|        :::|||:|:..||||:.:||:||.
  Rat   667 STLGENIADNGGVRQA---YKAYLQWLAEGGRD--------QRLPGLNLTYAQLFFINYAQVWCG 720

  Fly   664 DYEPEHYWEEL-TGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            .|.||...:.: |..|:..||||||::.|...|:|.:.||.|||||| ...||:|
  Rat   721 SYRPEFAIQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHP-MNRCRIW 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	204/740 (28%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	200/732 (27%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
Mmel1	NP_001101467.2	M13	106..772	CDD:341056	200/731 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344523
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850