DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and Kel

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001178540.1	Gene:	Kel / 297025	RGDID:	1565470	Length:	713	Species:	Rattus norvegicus

Alignment Length:	799	Identity:	184/799 - (23%)
Similarity:	311/799 - (38%)	Gaps:	215/799 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VCILICVILNDCEA------RSIGDESHENAITDETADYLRSHGAMMKSYMNFSVDPCDDFYEFA 76
            :.:|:|.:|..|..      |:.|..:.|:.:..|..::..:.|       |.|..||.||:.||
  Rat    31 LAVLLCGLLIGCSMLWVYIFRNCGPWTCESPVCMELVNHYLASG-------NRSAAPCTDFFSFA 88

  Fly    77 CGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRT-KLAEA-----LNVSAELLVAQRFYNS 135
            |              .::|  ..|.:...:.|:..:|. ||.||     |....|  .|.:||||
  Rat    89 C--------------EKAN--GTSNSFQALAEENKSRLWKLLEAPGSWHLESGEE--KAFQFYNS 135

  Fly   136 CLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSW----FNMSAHL--SNYG----VRS 190
            |:..:........| .:.:|:.|||        ||.|. :|    ||.:..|  |.||    .|:
  Rat   136 CMDTDAIEASGTGP-LVQIIKELGG--------WNISG-NWTFFDFNQNLRLLMSQYGHFPFFRA 190

  Fly   191 LIHEEILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMRG-YLKEYNLTKDEISAV 254
            .:|..  |..|..|..::.:..||.::.            |..|.::.. .|:||....:.:..:
  Rat   191 YLHPH--PAPPHTPIIQIDQPEFDILLQ------------QDQEQKVYAQILREYVTYLNRLGTL 241

  Fly   255 IEG------VFAFWSEALSIE-------DKFESDRDK------CDLLSEIEEVPRFGQWRSYYEI 300
            :..      ..|.||...:..       .:.:..:||      .|.|.|:  .|.. .|.|..:.
  Rat   242 LGSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQDKLFHVVTIDALQEM--APAI-DWLSCLQA 303

  Fly   301 AWNGIDFYNGSSGGEFCDFYYVE-----LDKVCAKHTEAVANYL------------------AMR 342
            .:..:.. :.|...:..|..|:.     :::....|:|.:.:|:                  |.|
  Rat   304 IFTPMSL-SPSQTLQVHDLDYLRNMSQLVEEGLLNHSEIIQSYMILGLVDTLSPALATKFQEARR 367

  Fly   343 FLYRMDDKLKE----PKQPEDQKVNCL----MIVQMTLPNLFNRLYMAEHFTDEKHSEISDMVTE 399
            .|.:...||||    |..|...|  |:    ...:.||..||    :.|.|.....|...::..|
  Rat   368 ELTQKLRKLKERPPLPAYPRWMK--CVEQTGSFFEPTLAALF----VHEAFGPSIRSAAMELFAE 426

  Fly   400 MRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKNEELSDTLIREINNLTIVEGSYAQSLI 464
            ::.|....|:.:.|:..|||.|||:|...:...:|:.|....::...:|.:::.: ..|:.||.:
  Rat   427 IKDAVIVRLKKLSWISEETRKEALNKLTQLQVEMGAPKRALKTEMAKQEYSDIQL-GPSFLQSFL 490

  Fly   465 NL------RVLGTYL-----HRYAGLHADELPKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLH 518
            :.      |.:.::|     ||:          ...|      ..|:|:|...|:.|...||:|.
  Rat   491 SCVRSLQGRKVRSFLQPFPYHRW----------QKSP------WSVSAYYSVPDHVVVFPAGLLQ 539

  Fly   519 PPAYHRSWPDSLKFGTIGYLIGHELTHGF------------DTEGSSFDSAGEVRDWWSRKSEAV 571
            ||.:|..:|.::.||.:|.::.|:|.|.|            ||.                    .
  Rat   540 PPFFHPGYPRAVNFGAVGSIMAHKLLHIFFQFLLPGGCPACDTR--------------------A 584

  Fly   572 FQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLA 636
            .||...|....:..:.:|.:: :..|:.|..||.||.||:..|...||..:  .:|:|
  Rat   585 LQEALLCLEHRYAAFPLPSMS-SFNGSHTLLENAADIGGVAIAFQAYRKRI--TERTG------- 639

  Fly   637 HKNEQMPGLDLSPEQLFFVGFAQLWCAD---YEPEHYWEELTGAHTVDKYRVLGAVSNNDDFAEV 698
              ...:|..:|||.||||..:||:.|.:   .:|:       ..|:..:.||.|.:||:.|||:.
  Rat   640 --ELTLPNQELSPYQLFFRSYAQVMCRELISQDPQ-------DTHSPPRLRVHGPLSNSPDFAKH 695

  Fly   699 YKCPLGSPMHPKAESCRMW 717
            :.||.||.::|... |::|
  Rat   696 FLCPSGSLLNPSTR-CKLW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	174/749 (23%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	171/741 (23%)
Kel	NP_001178540.1	PepO	75..713	CDD:226118	174/746 (23%)
Kel	NP_001178540.1	M13	78..711	CDD:189000	171/741 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344531
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.810