DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and Mmel1

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_038811.2	Gene:	Mmel1 / 27390	MGIID:	1351603	Length:	766	Species:	Mus musculus

Alignment Length:	769	Identity:	215/769 - (27%)
Similarity:	346/769 - (44%)	Gaps:	149/769 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RSIGDESHENAITDETADYLRSHGAMMKSYMNFSVDPCDDFYEFACGNW-KNVKTPRQSPHRRSN 95
            |::.|.|.::.|....:..:.:  |.:...|:.|.:||::||::|||.| ::...|  ..:.|.:
Mouse    64 RALRDSSLKSDICTTPSCVIAA--ARILENMDQSRNPCENFYQYACGGWLRHHVIP--ETNSRYS 124

  Fly    96 ILDISYTLMDVTEQLLTRTKLAEALNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGG 160
            :.||   |.|..|.:|..............:..|:..|.||:...:..:..::| .|||::.:||
Mouse   125 VFDI---LRDELEVILKGVLEDSTSQHRPAVEKAKTLYRSCMNQSVIEKRDSEP-LLSVLKMVGG 185

  Fly   161 FPAVDRDAWNASSFSWFNMSAHL----SNYGVRSLI------HEEILPQHPFNPYFKLPELGFDH 215
            :| |..|.||.:....:.:...|    |.:..|.||      .::...:|..  |...|.||.
Mouse   186 WP-VAMDKWNETMGLKWELERQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVI--YIDQPTLGM-- 245

  Fly   216 VVHTAHVANTSSRAYQL---NEHRMR-GYL-----------KEYNLTKDEISAVIEGVFAFWSEA 265
                      .||.|..   |.|::| .||           |:.||:|:  ||::....|   |.
Mouse   246 ----------PSREYYFQEDNNHKVRKAYLEFMTSVATMLRKDQNLSKE--SAMVREEMA---EV 295

  Fly   266 LSIEDKF-------ESDRD------KCDLLSEIEEVPRFG----QWRSYYEIAWNGIDFYNGSSG 313
            |.:|...       |...|      :.||: |::|  |||    .|..:.:...:.::
Mouse   296 LELETHLANATVPQEKRHDVTALYHRMDLM-ELQE--RFGLKGFNWTLFIQNVLSSVE------- 350

  Fly   314 GEFCDFYYVEL------------------DKVCAKHTEAVANYLAMRFLY----RMDDKLKEPK- 355
                    |||                  |.:.:.....:.|||..|.:.    .:..:.||.:
Mouse   351 --------VELFPDEEVVVYGIPYLENLEDIIDSYSARTMQNYLVWRLVLDRIGSLSQRFKEARV 407

  Fly   356 ----------QPEDQKVNCLMIVQMTLPNLFNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILES 410
                      ..|.:...|:..|...:.:....||:...|:.:..|.:.:::.::|......|:.
Mouse   408 DYRKALYGTTVEEVRWRECVSYVNSNMESAVGSLYIKRAFSKDSKSTVRELIEKIRSVFVDNLDE 472

  Fly   411 VEWLDAETRAEALSKEAGITPVIG--SYKNEELSDTLIREINNLTIVEGSYAQS-LINLRVLGTY 472
            :.|:|.|::.:|..|...|...||  .|..|:.:..|..|.::||..|..|.:: |.||:
Mouse   473 LNWMDEESKKKAQEKAMNIREQIGYPDYILEDNNKHLDEEYSSLTFYEDLYFENGLQNLK----- 532

  Fly   473 LHRYAGLHADEL-PKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIG 536
              ..|.....:| .|..:.|.::....|||||....|.:...||:|.||.:.:..|.||.||.||
Mouse   533 --NNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKDQPQSLNFGGIG 595

  Fly   537 YLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEI--NQTIRGNE 599
            .:||||:|||||..|.:||..|.:.||||..|...||:::||.:..:..:.. |:  ||.:.|..
Mouse   596 MVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFQQQSQCMIYQYGNFSW-ELADNQNVNGFS 659

  Fly   600 TRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCAD 664
            |..|||||.||:|.|   |:.:::.|    |||    .|::::|||:|:..||||:.:||:||..
Mouse   660 TLGENIADNGGVRQA---YKAYLRWL----ADG----GKDQRLPGLNLTYAQLFFINYAQVWCGS 713

  Fly   665 YEPEHYWEEL-TGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            |.||...:.: |..|:..||||||::.|...|:|.:.||.|||||| .:.||:|
Mouse   714 YRPEFAVQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHP-MKRCRIW 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	209/739 (28%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	205/731 (28%)
Mmel1	NP_038811.2	PepO	89..766	CDD:226118	209/740 (28%)
Mmel1	NP_038811.2	M13	97..764	CDD:189000	205/730 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841115
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950