Protein Alignment Nep7 and Mmel1

DIOPT Version :10

• Sequence 1: NP_651603.1
• Gene: Nep7 / 43356
• FlyBaseID: FBgn0039564
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_038811.2
• Gene: Mmel1 / 27390
• MGIID: 1351603
• Length: 766
• Species: Mus musculus
• Alignment Length: 769
• Identity: 215/769 - (27%)
• Similarity: 346/769 - (44%)
• Gaps: 149/769 - (19%)

  Fly    32 RSIGDESHENAITDETADYLRSHGAMMKSYMNFSVDPCDDFYEFACGNW-KNVKTPRQSPHRRSN 95
            |::.|.|.::.|....:..:.:  |.:...|:.|.:||::||::|||.| ::...|  ..:.|.:
Mouse    64 RALRDSSLKSDICTTPSCVIAA--ARILENMDQSRNPCENFYQYACGGWLRHHVIP--ETNSRYS 124

  Fly    96 ILDISYTLMDVTEQLLTRTKLAEALNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGG 160
            :.||   |.|..|.:|..............:..|:..|.||:...:..:..::| .|||::.:||
Mouse   125 VFDI---LRDELEVILKGVLEDSTSQHRPAVEKAKTLYRSCMNQSVIEKRDSEP-LLSVLKMVGG 185

  Fly   161 FPAVDRDAWNASSFSWFNMSAHL----SNYGVRSLI------HEEILPQHPFNPYFKLPELGFDH 215
            :| |..|.||.:....:.:...|    |.:..|.||      .::...:|..  |...|.||.
Mouse   186 WP-VAMDKWNETMGLKWELERQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVI--YIDQPTLGM-- 245

  Fly   216 VVHTAHVANTSSRAYQL---NEHRMR-GYL-----------KEYNLTKDEISAVIEGVFAFWSEA 265
                      .||.|..   |.|::| .||           |:.||:|:  ||::....|   |.
Mouse   246 ----------PSREYYFQEDNNHKVRKAYLEFMTSVATMLRKDQNLSKE--SAMVREEMA---EV 295

  Fly   266 LSIEDKF-------ESDRD------KCDLLSEIEEVPRFG----QWRSYYEIAWNGIDFYNGSSG 313
            |.:|...       |...|      :.||: |::|  |||    .|..:.:...:.::
Mouse   296 LELETHLANATVPQEKRHDVTALYHRMDLM-ELQE--RFGLKGFNWTLFIQNVLSSVE------- 350

  Fly   314 GEFCDFYYVEL------------------DKVCAKHTEAVANYLAMRFLY----RMDDKLKEPK- 355
                    |||                  |.:.:.....:.|||..|.:.    .:..:.||.:
Mouse   351 --------VELFPDEEVVVYGIPYLENLEDIIDSYSARTMQNYLVWRLVLDRIGSLSQRFKEARV 407

  Fly   356 ----------QPEDQKVNCLMIVQMTLPNLFNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILES 410
                      ..|.:...|:..|...:.:....||:...|:.:..|.:.:::.::|......|:.
Mouse   408 DYRKALYGTTVEEVRWRECVSYVNSNMESAVGSLYIKRAFSKDSKSTVRELIEKIRSVFVDNLDE 472

  Fly   411 VEWLDAETRAEALSKEAGITPVIG--SYKNEELSDTLIREINNLTIVEGSYAQS-LINLRVLGTY 472
            :.|:|.|::.:|..|...|...||  .|..|:.:..|..|.::||..|..|.:: |.||:
Mouse   473 LNWMDEESKKKAQEKAMNIREQIGYPDYILEDNNKHLDEEYSSLTFYEDLYFENGLQNLK----- 532

  Fly   473 LHRYAGLHADEL-PKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIG 536
              ..|.....:| .|..:.|.::....|||||....|.:...||:|.||.:.:..|.||.||.||
Mouse   533 --NNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKDQPQSLNFGGIG 595

  Fly   537 YLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEI--NQTIRGNE 599
            .:||||:|||||..|.:||..|.:.||||..|...||:::||.:..:..:.. |:  ||.:.|..
Mouse   596 MVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFQQQSQCMIYQYGNFSW-ELADNQNVNGFS 659

  Fly   600 TRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCAD 664
            |..|||||.||:|.|   |:.:::.|    |||    .|::::|||:|:..||||:.:||:||..
Mouse   660 TLGENIADNGGVRQA---YKAYLRWL----ADG----GKDQRLPGLNLTYAQLFFINYAQVWCGS 713

  Fly   665 YEPEHYWEEL-TGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            |.||...:.: |..|:..||||||::.|...|:|.:.||.|||||| .:.||:|
Mouse   714 YRPEFAVQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHP-MKRCRIW 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	M13	66..715	CDD:341056	205/731 (28%)
Mmel1	NP_038811.2	M13	97..764	CDD:341056	205/730 (28%)