DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and Phex

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_037136.2	Gene:	Phex / 25512	RGDID:	3323	Length:	749	Species:	Rattus norvegicus

Alignment Length:	740	Identity:	201/740 - (27%)
Similarity:	329/740 - (44%)	Gaps:	132/740 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 AMMKSYMNFSVDPCDDFYEFACGNW-KNVKTPRQSPH------RRSNILDISYTLMDVTEQLLTR 113
            |.:.|.:|.|||||::|:.|||..| .|...|...|.      .|.|: |:.  |..:.|:.::|
  Rat    64 AAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNV-DLK--LKALLEKSVSR 125

  Fly   114 TKLAEALNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIR-SLGGFPAVDRD-----AWNAS 172
            .:..||:. .|::|     |:||:..:...:..|.| .|.::| |...:|.::.:     .|:..
  Rat   126 RRDTEAVQ-KAKIL-----YSSCMNEKAIEKADAKP-LLHILRHSPFRWPVLEANIGPEGVWSER 183

  Fly   173 SFSWF-NMSAHLSNYGVRSLIHEEILP------QHPFNPYFKLPELGFDHVVHTAHVANTS-SRA 229
            .||.. .::.....|.....|...:.|      :|    ..||.:......|....:.||: :::
  Rat   184 KFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEH----ILKLDQATLSLAVREDFLDNTTEAKS 244

  Fly   230 YQLNEHRMRGYLKEYNLTKDEISAVIEGVFAFWSE-----ALSIEDKF------------ESDRD 277
            |       |..|  |....|  :||:.|..:..:|     .|.:|.|.            |:..:
  Rat   245 Y-------RDAL--YKFMVD--TAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYN 298

  Fly   278 KCDLLSEIEEVPRFGQWRSYYEIAWNGID--FYN-----GSSGGEFCDF--YYVELDKVC-AKHT 332
            |.::......:|:| .|..|.:   ..||  .|.     |.|.......  |:.:|.::. |:..
  Rat   299 KMNISELSAMIPQF-DWLGYIK---KVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILGAERK 359

  Fly   333 EAVANYLAMRFLYRMDDKLKEPKQ-----------------PEDQKVNCLMIVQMTLPNLFNRLY 380
            :.:||||..|.:|.....|....|                 |:..|  |:..::..||.:..:::
  Rat   360 KTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDK--CVNFIESALPYVVGKMF 422

  Fly   381 MAEHFTDEKHSEISDMVTEMRKAQRQILESV-EWLDAETRAEALSKEAGITPVIGSYKNEELSDT 444
            :..||.::|...:.:::..:|.|...:||.. ||:||.|:.:|..|...:...:| |....::||
  Rat   423 VNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAVLAKVG-YPEFIMNDT 486

  Fly   445 LIRE-INNLTIVEGSYAQSLINLRVLGTYLHRYAGLHAD------ELPKD---TKPLTLLVGMQV 499
            .:.| :..:...|..|..:::..|   .||     ..:|      .:||.   |.|.|      |
  Rat   487 YVNEDLKAIKFSESDYFGNVLQTR---KYL-----AQSDFFWLRKAVPKTEWFTNPTT------V 537

  Fly   500 NAFYYNLDNSVYVMAGVLHPPAY-HRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDW 563
            ||||....|.:...||.|..|.: ...:|.||.:|.||.::|||.|||||..|..:|..|.:..|
  Rat   538 NAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPW 602

  Fly   564 WSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRS 628
            ||..||..|:|:.:|.::.::.|...:....::|..|..|||||.||||.|...||..:.. :|.
  Rat   603 WSVDSEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWIND-RRQ 666

  Fly   629 GADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGAVSNN 692
            |.: |.|      :||:..:..||||:.:|.:.|..|.||...|:: .|||:..::||.||:||.
  Rat   667 GVE-EPL------LPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNF 724

  Fly   693 DDFAEVYKCPLGSPMHPKAESCRMW 717
            ::|.:.:.||..|.|:..|:|||:|
  Rat   725 EEFQKAFNCPANSTMNRGADSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	199/734 (27%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	194/726 (27%)
Phex	NP_037136.2	M13	74..740	CDD:341056	191/719 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920