DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and Kel

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_115929.3	Gene:	Kel / 23925	MGIID:	1346053	Length:	713	Species:	Mus musculus

Alignment Length:	816	Identity:	195/816 - (23%)
Similarity:	314/816 - (38%)	Gaps:	223/816 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RLPL-----YTR---LAVCILICVILNDCEA------RSIGDESHENAITDETADYLRSHGAMMK 59
            |||.     .||   :.:.:|:|.:|.....      |:.|....|..:..|..|:..:.|
Mouse    14 RLPTEWSRQLTRARWVLLAVLLCGLLLGSSMLWFYIFRNCGPCPCETPVCMELLDHYLASG---- 74

  Fly    60 SYMNFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRT-KLAEA---- 119
               |.||.||.||:.|||              .::|  ..|.:...:||:..:|. :|.||
Mouse    75 ---NRSVAPCTDFFSFAC--------------EKAN--GTSDSFQALTEENKSRLWRLLEAPGSW 120

  Fly   120 -LNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSW----FNM 179
             |....|  .|.:|||||:..:......:.| .:.:|..|||        ||.:. :|    ||.
Mouse   121 HLGSGEE--KAFQFYNSCMDTDAIEASGSGP-LIQIIEELGG--------WNITG-NWTSLDFNQ 173

  Fly   180 SAHL--SNYG----VRSLIHEEILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMR 238
            :..|  |.||    .|:.:...  |..|..|..::.:..||.::.              .|...:
Mouse   174 NLRLLMSQYGHFPFFRAYLRPH--PAPPHTPIIQIDQPEFDILLQ--------------QEQEQK 222

  Fly   239 GY---LKEYNLTKDEISAVIEG------VFAFWSEALSIE-------DKFESDRDK---CDLLSE 284
            .|   |:||....:.:..::..      ..|.||...:..       .:.:..:||   ...:.|
Mouse   223 VYAQILREYVTYLNRLGTLLGSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQDKLFHVVTIDE 287

  Fly   285 IEEVPRFGQWRSYYEIAWNGIDFYNGSSGGEFCDFYYVE-----LDKVCAKHTEAVANYL----- 339
            ::|:.....|.|..:..:..:.. |.|......|..|:.     :::....|.|::.:|:
Mouse   288 LQEMAPAIDWLSCLQAIFTPMSL-NSSQTLVVHDLDYLRNMSQLVEEGLLNHRESIQSYMILGLV 351

  Fly   340 -------------AMRFLYRMDDKLKE----PKQPEDQKVNCL----MIVQMTLPNLFNRLYMAE 383
                         |.|.|.:...||||    |..|...|  |:    ...:.||..||.|    |
Mouse   352 DTLSPALDTKFQEARRELIQELRKLKERPPLPAYPRWMK--CVEQTGAFFEPTLAALFVR----E 410

  Fly   384 HFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKNEELSDTLIRE 448
            .|.....|...::..|::.|....|:.:.|:..||:.|||:|.|.:...:|:.|.....|...:|
Mouse   411 AFGPSIQSAAMELFAEIKDAVIIRLKKLSWISEETQKEALNKLAQLQVEMGAPKRAVKPDIATQE 475

  Fly   449 INNLTIVEGSYAQSLIN------LRVLGTYL-----HRYAGLHADELPKDTKPLTLLVGMQVNAF 502
            .|::.: ..|:.||.::      .|.:.::|     ||:          ...|      .:|||:
Mouse   476 YNDIQL-GPSFLQSFLSCVRSLRARNVQSFLQPFPYHRW----------QKSP------WEVNAY 523

  Fly   503 YYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGF------------DTEGSSFD 555
            |...|:.|...||:|.||.:|..:|.::.||..|.::.|||.|.|            ||.
Mouse   524 YSISDHMVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCPACDTH----- 583

  Fly   556 SAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRN 620
                           |.||...|...::..:.:|.|: :..|:.|..||.||.||:..|...|..
Mouse   584 ---------------VLQEALLCLERHYAAFPLPSIS-SFNGSHTLLENAADIGGVAIAFQAYSK 632

  Fly   621 HMKQLQRSGADGETLAHKNE-QMPGLDLSPEQLFFVGFAQLWC---ADYEPEHYWEELTGAHTVD 681
            .:            :.|..| .:|.|||||.||||..:||:.|   :..:|:       ..|:..
Mouse   633 RI------------VEHTGELTLPNLDLSPYQLFFRSYAQVMCRGLSSQDPQ-------DPHSPP 678

  Fly   682 KYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            ..||.|.:||..|||:.:.||.|:.::|.|. |::|
Mouse   679 SLRVHGPLSNTPDFAKHFHCPRGTLLNPSAR-CKLW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	180/749 (24%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	177/741 (24%)
Kel	NP_115929.3	M13	78..711	CDD:341056	177/741 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.810