DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and Ece1

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001356106.1	Gene:	Ece1 / 230857	MGIID:	1101357	Length:	769	Species:	Mus musculus

Alignment Length:	797	Identity:	206/797 - (25%)
Similarity:	337/797 - (42%)	Gaps:	189/797 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LYTRLAVCILICVILNDCEARSIGDESH------ENAITDETADYLRSHGAMMKSYMNFSVDPCD 70
            |.|.||..::.|:     .|..|..::.      ..|....|:..|.|        |:.:||||.
Mouse    71 LVTLLAAGLVACL-----AALGIQYQTRTPPVCLTEACVSVTSSILNS--------MDPTVDPCQ 122

  Fly    71 DFYEFACGNWKNVK-TPRQSPHRR----SNILDISYTLMDVTEQLLTRTKLAEALNVSAELLVAQ 130
            ||:.:|||.|  :| .|....|.|    ||:.:.:..   |.:.||.        |.:|.:..|:
Mouse   123 DFFSYACGGW--IKANPVPDGHSRWGTFSNLWEHNQA---VIKHLLE--------NATASVSEAE 174

  Fly   131 R----FYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWF--NMSAHLSNYGVR 189
            |    :|.:|:.........|.| .:.:|..|||        ||.:. .|.  |....|
Mouse   175 RKAQVYYRACMNETRIEELRAKP-LMELIEKLGG--------WNITG-PWAKDNFQDTL------ 223

  Fly   190 SLIHEEILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMRGYLKEYNLTKDEISAV 254
                :.:...:..:|:|.        |..:|...|::|...|:::..:....::|.|.|.|...|
Mouse   224 ----QVVTAHYRTSPFFS--------VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKV 276

  Fly   255 IEGVFAFWSEALSIEDKFESD--RDKCDLLSEIE------EVP---RFGQWRSYYEI-------- 300
            :.|...:..:...:....:.|  |.:...:.:.|      .:|   |..:...|:::
Mouse   277 LTGYLNYMVQLGKLLGGGDEDAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTL 341

  Fly   301 --AWNGIDFYNGSSGGEFCDFYYVEL---------DKVCAKHTEAVA---------NYLAMRFLY 345
              |.|.:.|.|       ..||.||:         ||...:....:.         ||:....:.
Mouse   342 APAINWLPFLN-------TIFYPVEINESEPIVVYDKEYLRQVSTLINNTDKCLLNNYMMWNLVR 399

  Fly   346 RMDDKLKEPKQPEDQKVN----------------CLMIVQMTLPNLFNRLYMAEHFTDEKHSEIS 394
            :....|.:..|..|:|..                |:...:..|......:::...|.::..:..|
Mouse   400 KTSSFLDQRFQDADEKFMEVMYGTKKTCIPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIAS 464

  Fly   395 DMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKN-----EELSDTLIREINNLTI 454
            :::.|::||..:.|.:::|:|.|||..|..|...|..:|| |.|     :||.    :..|:.|.
Mouse   465 EIIMEIKKAFEESLSTLKWMDEETRRSAKEKADAIYNMIG-YPNFIMDPKELD----KVFNDYTA 524

  Fly   455 VEGSYAQSLINL-----RVLGTYLHRYAGLHADELPKD--------TKPLTLLVGMQVNAFYYNL 506
            |...|.::.:..     ||.           ||:|.|.        |.|:       |||:|...
Mouse   525 VPDLYFENAMRFFNFSWRVT-----------ADQLRKAPNRDQWSMTPPM-------VNAYYSPT 571

  Fly   507 DNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAV 571
            .|.:...||:|..|.|.||.|::|.||.||.::||||||.||.:|..:|..|.:|.||...|...
Mouse   572 KNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEA 636

  Fly   572 FQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLA 636
            |:::.:|.|..::.|.:.  .:.:.|..|..|||||.|||:||...|:|.:|   ::||:
Mouse   637 FKQQTECMVQQYSNYSVN--GEPVNGRHTLGENIADNGGLKAAYRAYQNWVK---KNGAE----- 691

  Fly   637 HKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGAVSNNDDFAEVYK 700
               :.:|.|.|:..||||:||||:||:...||...|.| |..|:..::||:|::||:.:|:|.::
Mouse   692 ---QTLPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFR 753

  Fly   701 CPLGSPMHPKAESCRMW 717
            ||.||||:|. ..|.:|
Mouse   754 CPPGSPMNPH-HKCEVW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	194/741 (26%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	192/733 (26%)
Ece1	NP_001356106.1	M13	118..767	CDD:341056	192/733 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841073
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850