DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and nep-20

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001317749.1	Gene:	nep-20 / 188176	WormBaseID:	WBGene00020293	Length:	834	Species:	Caenorhabditis elegans

Alignment Length:	711	Identity:	147/711 - (20%)
Similarity:	267/711 - (37%)	Gaps:	163/711 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 MKSYMNFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRTKLAEALNV 122
            :.:|.:.||..|.:||:..||.:|:.:.  ...||.:...::   :..:..:.|.|.:    .::
Worm   227 LSAYQDTSVSKCHNFYKATCGKYKHHQA--LDKHRDAKKKEV---VKRIVREFLRRNE----SSI 282

  Fly   123 SAELLVAQR-FYNSCLAAELFPRPAADPAYLSV---IRSLGGFPAVDRDAWNASSFSWFNMSAHL 183
            :::...|.| .:..|      .:.:.:..||.:   |..:|.:|.:..|        |.::..:|
Worm   283 TSKFEPAIRLMFGKC------NKFSQNKTYLDIFKDIEKIGPWPVLKSD--------WVDVMFNL 333

  Fly   184 SNYGVRSLIHEEILPQHPFNPY--FKLP--ELGF-----------------DHVVHTAHVANTSS 227
            ::| :.||:      :..|..:  |||.  :|.|                 :.::.....||
Worm   334 NDY-LLSLV------ELGFTDFGLFKLEFRQLAFGQFPVIAPSEQKQGNQLEKIILEILEAN--- 388

  Fly   228 RAYQLNEHRMRGYLKEYNLTKDEISAV-IEGV----FAFWSEALSIE-----DKFESDRDKCDLL 282
             ..|.:..::..||:||:..|.::..: :||.    ..:.:..||:.     .|.........|:
Worm   389 -GVQADRQKLSKYLREYSEFKSQLRHMSLEGTSVKYIRYNASTLSVNISALVQKMAPMSTSSGLV 452

  Fly   283 SEIEEVPRFGQWRSYYEIAWNGIDFYNGSSGGEFCDFYYVELDKVCAK-HTEAVANYLAMRFLYR 346
            ..|:                :||...|.||      |:...||.:..: |...:||||...|:..
Worm   453 RRIQ----------------SGILITNSSS------FFGKNLDAIIQQTHKRTLANYLIFHFIDA 495

  Fly   347 MD-DKLKEPKQPEDQKVNCLMIVQMTLPNLFNR---LYMAEHFTDEKHSEIS-DMVTEMRKAQRQ 406
            :. |.....|..|.           ||.:|..|   ..:::.|.||:...:. :|..:::|...:
Worm   496 VTFDLTSGAKHSEH-----------TLIDLLPRGSLQVLSQDFVDEEDQGVMVEMAKDLKKHVVE 549

  Fly   407 ILESVEWLD-------AETRAEALSKEAGITPVIGSYKNEELSDTLIREINNLTIVEGSYAQSLI 464
            ::.....||       .:.|.:.:.|...|. |:..|..|.|:...  |..|||     |:.||.
Worm   550 MISEGSSLDKGHLVFEEKERRKLIRKVQDIL-VVTKYPLEILNQNF--EKLNLT-----YSDSLH 606

  Fly   465 NL-----RVLGTYLHRYAGLHADELPKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHR 524
            .:     |.....|..|.|...|...|         ||..:|.|....|.:.::|.::..|.:..
Worm   607 KIIQKLRRFRSEQLIEYLGGDLDPTDK---------GMWGSAHYEQATNDLIIIAPIIDGPYFDT 662

  Fly   525 SWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIP 589
            |:|:.:....:|::|..||....|:.....|..|...:|...:|...|....:|:
Worm   663 SYPNYVNIFFMGFIISRELGRSLDSVRIRKDEKGHTENWLKSESLKRFDNNVKCW---------- 717

  Fly   590 EINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLD-LSPEQLF 653
              .:.|.|....:|.:||..|..|:....:...|::     :|..:    |::.|.: ::.||:|
Worm   718 --RKKITGTRFLNEMLADHVGHEASFMALKKWEKEM-----NGTIV----EKIRGYESMTMEQIF 771

  Fly   654 FVGFAQLWCADYEPEHYWEELTGAHTVDKY--RVLGAVSNNDDFAEVYKCPLGSPMHPKAE 712
            |...|..:|.  .|.....|||.......|  ||..|..|...||:.:.|.....|:.|.:
Worm   772 FHLQALYFCR--PPGGSTGELTAKDARQHYSTRVNEAFKNMPQFAKAFGCSSNQNMNSKTK 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	147/709 (21%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	145/703 (21%)
nep-20	NP_001317749.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920