DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and nep-2

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_494343.2	Gene:	nep-2 / 188090	WormBaseID:	WBGene00020230	Length:	736	Species:	Caenorhabditis elegans

Alignment Length:	739	Identity:	200/739 - (27%)
Similarity:	324/739 - (43%)	Gaps:	117/739 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ETADYLRSHG-----AMMKSYMNFSVDPCDDFYEFACGNW-KNVKTPRQSPHRRSNILDISYTLM 104
            :::|...|.|     :::.|.||.||||||||||||||.| |....|..:| ..||..::...|.
Worm    48 DSSDVCLSPGCIKTASVILSSMNSSVDPCDDFYEFACGQWIKGHPIPDDAP-SVSNFENLGQDLE 111

  Fly   105 DVTEQLLTRTKLAEALNVSAELLVAQRFYNSCL-AAELFP--RPAADPAYLSVIRSLGGFPAVDR 166
            ...::||...........|| :..|:.|||.|| .:|:..  |...|    .|::|.||:|::..
Worm   112 FALKELLDENDEPYDYETSA-VGKAKYFYNLCLNESEILDNWRTTFD----EVVKSFGGWPSLGH 171

  Fly   167 DAWNASSFSWFNMSAHLSNYGVRSLIHEEILPQHPFNPYFKL----PELGFDHVVHTAHVANTSS 227
            .....:|.... .:..::.:...||....:.|....:....|    |:|            |..:
Worm   172 QMKPDASIEML-YADMVAKFKADSLFKATVQPDDKNSQRHVLLIDQPQL------------NLFA 223

  Fly   228 RAYQL---NEHRMRGYLKEYN-----LTKDEISAVIEG--VFAFWSEALSIEDKFESDRDKCDLL 282
            |.:.:   ||.|| .||:...     |..|...|.::.  :..|.:...:|....|...|..:|.
Worm   224 RDFYVAAENEERM-AYLQLIRDVLILLDADRTRATLDAKEIIDFETALANITMADEHRHDIAELY 287

  Fly   283 SEI------EEVPRFGQWRSYYEIAWNGIDFYNGSS------------GGEFCDFYYVELDKVCA 329
            ::|      ..:|.| .|..::...:..:...||..            |.||..    .||.:..
Worm   288 TKITLGEMRRSLPHF-NWPLFFNRMFKDLHEKNGKRITFDDNTEVVVYGYEFLR----RLDVLIP 347

  Fly   330 KH-TEAVANYLAMRFLYRMDDKLKEPKQP---------------EDQKV---NCLMIVQMTLPNL 375
            :: ...:.|||...:.::  ..|::...|               ..|||   .|:..:...:|..
Worm   348 QYDNRLIVNYLEWCWFFK--TMLRDLPDPFALTIFKFYKTLNIMNVQKVRWHGCVTRINSLMPMA 410

  Fly   376 FNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIG--SYKN 438
            .:.:|:..||..|...::.:|::.:.::...:|.|.:||..||:..|..|...:...||  .|.|
Worm   411 TSAIYVKNHFDHEAKQQVEEMISLIMESFVDLLLSEDWLTKETKQTAKQKVNEMKRKIGYPDYLN 475

  Fly   439 EELSDTLIREINNLTIVEGSYAQSLINLRVLGTYLHRYAGLHADELPKDTKPLT----LLVGMQV 499
            :..:  :..|.....:..|.|.|:..:.         |.....|.|.:.|:.:.    :.....|
Worm   476 DPAA--VNNEYKTFKVYPGHYYQTKFSF---------YEQYQRDVLERITEAVDRERWVAGAALV 529

  Fly   500 NAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWW 564
            ||||....|.:...||:|.|..|.:.:|.|:.||.||.:||||:|||||..|..:|:.|.:|.||
Worm   530 NAFYSPNTNEIIFPAGILQPVFYSKDFPSSMNFGGIGVVIGHEITHGFDDRGRLYDNLGNIRQWW 594

  Fly   565 SRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSG 629
            ...:.:.|:.:|||....::.|::.:||..|.|..|:.|||||.|||:.|...|:.:.|:..|.
Worm   595 DNATISKFEHKAQCIEKQYSSYVLDQINMQINGKSTKGENIADNGGLKQAYRAYKKYEKRHSRP- 658

  Fly   630 ADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGAVSNND 693
                      .::||::|:.:||||:.:||:||.....:....:| |..|:....||.|.:||:.
Worm   659 ----------PRLPGVNLTHDQLFFLNYAQIWCGTMNDKEAIRKLRTSEHSPGPIRVKGPLSNSY 713

  Fly   694 DFAEVYKCPLGSPMHPKAESCRMW 717
            |||:.|.|..||.|:|: |.||:|
Worm   714 DFAKAYNCEPGSQMNPR-EKCRVW 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	196/718 (27%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	190/710 (27%)
nep-2	NP_494343.2	PepO	61..736	CDD:226118	196/724 (27%)
nep-2	NP_494343.2	M13	73..734	CDD:189000	190/710 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4162
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870