DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and nep-18

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_494297.1	Gene:	nep-18 / 186911	WormBaseID:	WBGene00019343	Length:	701	Species:	Caenorhabditis elegans

Alignment Length:	775	Identity:	177/775 - (22%)
Similarity:	284/775 - (36%)	Gaps:	223/775 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 AMMKSYMNFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILD------ISYTLMDVTEQLLTR- 113
            ||:|:|.|.|||||:||:|..||        |.|.|    ::|      :.|      :|||.:
Worm    37 AMIKNYQNASVDPCEDFFEHTCG--------RYSEH----VMDDNSWGYVQY------KQLLYQV 83

  Fly   114 -----------TKLAEALNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIRS----LGGFPA 163
                       :|..|.|.:         |..|||     .|...|......:|:    .||||.
Worm    84 FAIARKTNKFNSKPNEQLRI---------FTKSCL-----DRKEMDEDTFQDLRNDIEERGGFPM 134

  Fly   164 VDRDAWNASSFSWFNMSA-HLSNYGVRSLIHEEILPQHPFNPYFKLPELGFDHVVHTAHVANTSS 227
            :|.: ||...|...:|.| :||                     .....:||..|...|.:....|
Worm   135 IDPN-WNEEKFDLSDMLAKYLS---------------------INRNRMGFLSVEPYAAIEGNKS 177

  Fly   228 --RAY-QLNEHRMRGYLKEYNLTKDEISAVIEGVFAF-------------WSEALSIE------- 269
              |.| ....|.:..:....::.||.::.::..:...             ::|.:.:|
Worm   178 VNRLYVSPGPHWVYNWAMGISIYKDSVAFMLRRLLKLENRELNETIYDKEFAELVQLEANFSTLA 242

  Fly   270 ---------DKFESDRDKCDLLSEIEEVPRFGQW-RSYYEIAWNG---------IDFYNGSSGGE 315
                     |.....|:..||:..|.|:    .| :....:|.:|         ::.......||
Worm   243 DYRNLALDNDNMSKSRNLTDLVKMIPEI----DWIKILKALARHGTSEEDEEKLLERVTVHGAGE 303

  Fly   316 FCDFYYVELDKVCAKHTE----AVANYLAMR-------FLYRMDDKLKEPKQPE-----DQKVNC 364
               :::.|..::....||    |:||||.:|       :.|..|    :|:|.:     ||:..|
Worm   304 ---YFFGENRELARIATETPKSALANYLVVRQLIDVALYFYDKD----QPRQNKFYNHVDQQSFC 361

  Fly   365 LMIVQMTLP----NLFNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSK 425
            ...|....|    |:|   ..:..|..|....|.:|..:::....||....|:|:.|.|...:.|
Worm   362 ATQVASFFPMPSMNVF---IESSQFKIENLKVIEEMFVKIKAEYEQIFTENEYLELEIREFLIRK 423

  Fly   426 EAGITPVIGSYKNEELSDTLIREINNLTIVEGS------------YAQSL------------INL 466
            ...|....|..:..|....|.:....|..::..            :::.|            :||
Worm   424 LNAIDGKFGLDQYTEGKPLLEKMYETLNFLDTDSPWQVYMKMWRHWSEQLVEHIVHDTPLDPVNL 488

  Fly   467 RVLGTYLHRYAGLHADELPKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLK 531
            ::.||        ||...|            ..|.||.||....|        |.....:|.:..
Worm   489 KMFGT--------HAAYQP------------YPNHFYINLPYLTY--------PWMDADFPANTN 525

  Fly   532 FGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWW---SRKSEAVFQERAQCYVDYFNQYLIPEINQ 593
            :|.:||:||||:.|.||......|.:|..:.:|   :..|...::.|.:|..|.::.|..|..:.
Worm   526 YGYLGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTETNSSNTEYELREKCLRDQYSAYKEPGYDF 590

  Fly   594 TIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFA 658
            .:.|...|.|...|..|:|.|...:....|:             ...::|||::|.|||||..:|
Worm   591 FMNGTHCRYEIAGDHMGIRTAFRVFEKVKKE-------------DRFRLPGLEMSEEQLFFYNYA 642

  Fly   659 QLWCADYEPEHYWEE-LTGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717
            ...|..|.|...... |...|..::|||.|.:.|..:|||.:.||..|||:|:.: |:::
Worm   643 FRQCDVYNPNKLPRNMLARQHPTNRYRVNGVIQNIPEFAEAFNCPKNSPMNPEMK-CKLY 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	174/769 (23%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	170/761 (22%)
nep-18	NP_494297.1	PepO	42..692	CDD:226118	170/758 (22%)
nep-18	NP_494297.1	M13	47..699	CDD:189000	170/761 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920