DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep7 and nep-8

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001309548.1	Gene:	nep-8 / 184631	WormBaseID:	WBGene00017553	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	722	Identity:	160/722 - (22%)
Similarity:	292/722 - (40%)	Gaps:	121/722 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LAVCILICVI-------------LNDCEARSIGDESHENAITDETADYLRSHGAMMKSYMNFSVD 67
            :||.:|:.::             :|..|..|||::.....:.|.......||..:  :|.:.|||
Worm    15 VAVNLLLLIVFLAMVTVHIKVEPVNLDELLSIGNDVDSKNLCDSPECITLSHELL--NYQDPSVD 77

  Fly    68 PCDDFYEFACGNWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRTKLAEALNVSAELLVAQRF 132
            ||.||::.:||.:...........::.:||     ...:.|.|   .|:..:.:.|..|:  :..
Worm    78 PCVDFFQHSCGRFHEQSVSESRLQKKKHIL-----RKQIREFL---HKIQNSTSKSENLM--KLV 132

  Fly   133 YNSCLAAE-------LFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSWFNMSAHLSNYGVRS 190
            ::.|.|::       ...|.|....: :.|:.:|.:|.:|:: |:.|.|....|.::|...|..:
Worm   133 FDKCEASKKTSNDNYKISRDAIHDVF-NDIKKIGAWPLLDKN-WDGSKFDLNEMLSNLVKLGATN 195

  Fly   191 L----IHEEILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLN-----EHRMRGYLKEYN- 245
            |    :...||.:..|...  .|.||  .:||.:.:.:..|...:.|     ...:....:||:
Worm   196 LGLFQLDFRILTEGKFVRI--APTLG--SIVHNSTMISMISEILEANGVQPDSEEISKEFEEYSS 256

  Fly   246 ----LTK----DEISAVIEGVFAFWSEALSIEDKFESDRDKCDLLSEIEEVPR----FGQWRSYY 298
                |.|    .::|..:.||.:.         .|.|      |::|:....|    ||:.|
Worm   257 LQMKLAKYQSSGKLSISLPGVRSI---------NFSS------LITEMIHPSRVSKIFGKIR--- 303

  Fly   299 EIAWNGIDFYNGSSGGEFCDFYYVELDKVC-AKHTEAVANYLAMRFLYRMDDKLKEPKQPEDQKV 362
             :..:....:..|:..|       .||.:. :...:.:||:|...::....:.:|..:     :.
Worm   304 -VVTSEHPLFFKSNETE-------SLDTIIESTSNKTLANFLIFNYIQSSYNIMKGAR-----RG 355

  Fly   363 NCLMIVQMTLPNLFNRLYMAEHFTDEKHSE-ISDMVTEMRKAQRQILESVEWLDAETRAEALSKE 426
            ||...|:...|....|::| .:|.|:.:.: :..:..|::|...::::..|.|....:...|.|.
Worm   356 NCEDDVRREFPRASLRVFM-RNFVDKGNRDGVKKLTEELKKNTLEMIQDTENLAPPVKESMLKKV 419

  Fly   427 AGITPVIGSYKNEELSDTLIREINN--LTIVEGSYA--QSLINLRVLGTYLHRYAGLHADELPKD 487
            ..|...||...:.:...||.:|..|  |...:..|.  |.|..||     ..:.....|.|.|
Worm   420 EAIKVTIGYPDHFDPPGTLDKEFENFDLDSTDSYYRIFQKLNRLR-----SEQQMEFIAGETP-- 477

  Fly   488 TKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGS 552
            ..|:..:  ::|||.|....|::.|.|..|..|.:..::||.:.....|:||.||:.|..|..|.
Worm   478 ISPIKEV--LKVNANYKRSKNALTVFAPFLDDPFFDITYPDYVNLFFSGFLIAHEIGHSVDANGL 540

  Fly   553 SFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTG 617
            .:|..|:..|....:....:.::.||.||.::.|..|...:.:.|..:.:|.|||..|.......
Worm   541 GYDENGKPMDGIRLEHVTEYGKQGQCLVDQYDNYDDPVYGKKMNGTHSINEIIADWVGHEVTWRA 605

  Fly   618 YRNHMKQLQRSGADGETLAHKNEQMPGL-DLSPEQLFFVGFAQLWCADYEPEHYWEELTGAHTVD 681
            |    |::..|         |...:.|| |::.:||:|...:.|:|.:.:.....|.|...:..|
Worm   606 Y----KKMDTS---------KMLSLIGLKDINMDQLYFRVQSLLFCRERDTISLEETLKDVYPTD 657

  Fly   682 KYRVLGA 688
            .:||.||
Worm   658 NFRVNGA 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	149/665 (22%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	147/659 (22%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	145/657 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28632
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930