DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep7 and nep-22

DIOPT Version :9

Sequence 1:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_509528.1	Gene:	nep-22 / 181144	WormBaseID:	WBGene00020788	Length:	798	Species:	Caenorhabditis elegans

Alignment Length:	782	Identity:	170/782 - (21%)
Similarity:	297/782 - (37%)	Gaps:	166/782 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ETADYLRSHGAMMKSYMNFSVDPCDDFYEFACGNW-KNVKTPRQSPHRRSNILDISYTLMDVTEQ 109
            :.|:||.:.       ::.:||||.|||.|.|..: :|....:..   ||.:.......:||..:
Worm    70 QAANYLLNG-------LDDTVDPCQDFYAFTCNKFLQNTDLQKLG---RSRLGTYDQAQVDVYSE 124

  Fly   110 LL----------TRTKLAEALNVSAELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFP-- 162
            ::          |.|...|.:..:|        :.:|......|.......|..:....||.|
Worm   125 IVAALSKIDVTSTTTSKTERITKAA--------FETCKNNLASPADKTAVVYAEITSLFGGVPFF 181

  Fly   163 ----AVDRDAWNASSFSWFNMSAHLSNYGVRSLIHEEILPQHPFNPYFKLP---ELGFDHVVHTA 220
                ..:.|.|..:.......:.....|.:.|..:::    |..|..:..|   .|..|..|...
Worm   182 GEPLKTNVDYWMVAGQIEQKHAVGTLTYTIASSDYKD----HTKNALYTGPPGLSLARDFYVKPQ 242

  Fly   221 HVANTSSRAYQLNEHRMRGYLKEY-NLTKDEISAVIEGVFAFWSEALSIEDKFESDRDKCDLLSE 284
            ::|..:.|...:|:     .|..: |..|..:.|  :.:.|...|.::.|.:........|||..
Worm   243 YIAEVNQRVSDVND-----LLTAFANAAKKNVGA--DALLAAAQEVVNFEVQIAMASWPDDLLRN 300

  Fly   285 IEE------------VPRFGQWRSYYEIAWNGIDFYNGSSGGEFCDF--------YYVELDKVC- 328
            .::            ..|...|:||....::|:     :|..:..::        |:..|:.|.
Worm   301 YQQQYNPYNIASATTAYRAINWKSYLGQLFHGV-----ASDADQANYNIVVTEPSYFAWLNSVFD 360

  Fly   329 --AKHTEAVANYLAMRFLYRMDDKLKEPKQPEDQKVN---------------------------- 363
              ..::..||||:..:.|....|.:    .|...||:
Worm   361 GKTSNSTVVANYMIAQLLADESDFI----NPATAKVSSDTNYIHYALRNGRGIKKIGKREYRMAD 421

  Fly   364 -------CLMIVQMTLPNLFNRLYMAEHFTDEK-HSEISDMVTEMRKAQRQILESVEWLDAETRA 420
                   |:.::...:|.....:|:.......| .:::.|..|.:....:.:::|:.|:|..::.
Worm   422 LDGISEGCMDLLTAYMPYGTGYVYVKSKSERNKVQADVKDQTTLIINNFQGMIDSLNWMDTFSKN 486

  Fly   421 EALSKEAGITPVIGSYKNEELSDTLIREINNLTIVEGSYAQ---SLINL------RVLGTYLHRY 476
            .|.:|...:.      ||....:.:..:.|:.|.|: :|.|   |:|:|      .:.|.:....
Worm   487 RAHNKSDSLV------KNFGWPEAMFGDFNDFTTVD-AYNQDYASIIDLYTKDKNDIYGIFAVLK 544

  Fly   477 AGLHADEL------PKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTI 535
            .|:...|.      |.|.........| |||:|....||:.......:||.|:.::|.:..|...
Worm   545 KGMEVREFFRIMGEPADRTNFLQSPAM-VNAWYQPERNSITFPYAAWNPPYYNLNYPQAYNFAGQ 608

  Fly   536 GYLIGHELTHGFDTEGSSFDSAGEVRD-------WWSRKSEAVFQERAQCYVDYFNQYLIPEINQ 593
            |...|||||||:|.||..|...||:.|       |....|.:.|.:.|||.|..|:....||...
Worm   609 GGTGGHELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDMAQCVVTQFSTQCCPEKTG 673

  Fly   594 TI---RGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQMPGLD-LSPEQLFF 654
            .|   .|..|:.|||||.||.:||...||.:: ...|.|.:       .:::|||: .:|.|:|:
Worm   674 NIHCANGATTQGENIADLGGQQAAYRSYRQYV-ATTRKGVE-------EDRLPGLENYTPNQIFW 730

  Fly   655 VGFAQLWC---ADYEPEHYWEELTGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAES-CR 715
            :.:...||   :|....|  :.||..|:..:.|....:.:..:|.:.:.|..||||:|:... |:
Worm   731 ITYGYSWCMKQSDANLVH--QLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMYPEPSGRCK 793

  Fly   716 MW 717
            :|
Worm   794 VW 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep7	NP_651603.1	PepO	60..717	CDD:226118	166/766 (22%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	165/758 (22%)
nep-22	NP_509528.1	PepO	76..795	CDD:226118	166/774 (21%)
nep-22	NP_509528.1	M13	83..793	CDD:189000	165/758 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4162
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870